多发性神经瘤

There were 36 males and 40 females,with the average age of 47.7 years.36 patients presented with sciatica and perineal numbness,11 patients had painless mass and the other 20 were identified due to other causes.Among 67 benign neurogenic tumors,54 were originated from S1-S3 nerves,3 from S4-S5 nerves and 11 from the presacral space without caudal involvement.Giant cell tumor was found in 60 patients,which included 24 males and 36 females,with an average age of 32 years.Upper sacrum（S1-S2） was involved firstly.There were 56 patients（average,37.7 years） diagnosed as other primary benign bone tumors,which included 24 cases of teratomas,epidermoid cyst or dermoid cyst.Other malignant tumors,including chondrosarcoma （17）,Ewing′s sarcoma/PNET（14）,multiple myeloma（12）,lymphoma（6） and osteosarcoma（6） were found in 64 patients.

其中脊索瘤95例，男62例，女33例，平均年龄55.7岁，骶尾区疼痛是主要症状（82例），半数以上患者伴有坐骨神经痛，肿瘤多先累及低位骶骨（S3~S5）；神经源性肿瘤76例，男36例，女40例，平均年龄47.7岁，神经纤维瘤43例，神经鞘瘤24例，恶性神经鞘瘤9例，主诉多为坐骨神经痛、会阴部麻木（36例）和无痛性包块（11例），20例患者为查体或其他原因检查时发现，67例骶骨良性神经源性肿瘤起源于S3以上神经者54例，起源于S3以下神经者3例，发生于骶前未累及骶管者10例；骨巨细胞瘤60例，男24例，女36例，平均年龄32岁，腰骶尾部不适（37例）、坐骨神经痛（21例）是主要的临床表现，肿瘤多先累及上位骶骨（S1~S2）；骶骨其他原发良性肿瘤及瘤样病变56例，包括畸胎瘤、皮样囊肿、表皮样囊肿共24例；其他原发恶性肿瘤64例，包括软骨肉瘤17例，尤文肉瘤14例，多发性骨髓瘤12例，成骨肉瘤6例等。

When MR imaging shows thickening and enhancement of the pituitary stalk and associated leptomeningeal disease as in this case, sarcoidosis is a very strong possibility, along with meningitis, particularly fungal.

结节病为一种不明原因的炎性病变，可以影像多个系统，包括中枢神经系统，女性多见，大于10：1，黑人比白人更多见，15%病人累及中枢神经系统，5%有神经症状，脑神经功能障碍和尿崩症是最常见的神经系统结节病的临床表现，MR改变包括脑膜增厚及强化，孤立性肿块或多发性小，散在的脑膜或实质病变，此例病例中MR图像出现增厚强化的垂体蒂伴有软脑膜病变，强烈提示结节病，伴随脑膜炎尤其是真菌性，通常T2表现为低信号，虽然这些也能够在霉菌病/淋巴瘤/脑膜瘤中看到。

PPO gene was not detected in the multiple myelome、 malignant fibrous histiocytoma 、malignant lymphoma、malignant neurosarcoma、solitary plasmacytoma of bone、primitive neuroectodermal tumors、lipoma、 osteosarcoma and sarcoenchondroma.

PPO基因在多发性骨髓瘤、恶性纤维组织细胞瘤、恶性淋巴瘤、恶性神经肉瘤、孤立性浆细胞肉瘤、原始神经外胚瘤、脂肪瘤、骨及软骨肉瘤等肿瘤中没有表达。在骨巨细胞瘤中有微弱表达。

Malignant peripheral nerve sheath tumor is an aggressive spindle cell sarcoma that is closely associated with neurofibromas, neurofibromatosis type 1 and from the sites previously irradiated.

恶性周边神经髓鞘瘤是一种恶性纺锤细胞肉瘤，和神经纤维瘤、第一型多发性神经纤维瘤症和以前接受过放射治疗的部位有密切相关。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。