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多发性关节炎

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The suppression to the granuloma induced by croton oil and paw edema of adjuvant-induced polyarthritis in rats were utilized to verify the inhibition to the chronic inflammation.

对慢性炎症的抑制作用以巴豆油诱导的大鼠肉芽肿和福氏完全佐剂诱导的多发性关节炎进行分析。

Purpura, angioedema, and facial swelling were not seen, but dermographism was present in 1 patient. Six patients had fever, 7 had polyarthritis, and 6 had leukocytosis. Seven patients had associated systemic diseases: adult-onset Still disease (3 patients), systemic lupus erythematosus (3 patients), and Schnitzler syndrome (1 patient).

没观察到紫癜,血管性水肿和额面水肿,但是有1名患者有皮肤划痕现象,6名患者有发热,7名有多发性关节炎,还有6名有患者有白细胞的增多。7名患者与全身性疾病有关:成人发病的斯蒂尔病(3名),全身性系统性红斑狼疮(3名)和薛尼兹勒氏综合症(1名)。

The major symptoms of SLE are the following: butterfly shaped Malar rash particularly on cheeks, discoidal rash, Photosensitivity, regular oral ulcers, nonerosive Arthritis, Pleuritis or Pericarditis, renal disorder, neurologic disorder, hematologic disorder, immunologic disorder, Anti-nuclear Antibody Test positive. Patients who are present any four of above symptoms can be clinically classifi-ed as SLE patients.

SLE的主要临床徵候包含:脸上呈蝴蝶状分布的红斑、身体出现圆盘状红斑、对阳光过敏、经常口腔溃疡、多发性关节炎、胸膜炎或心包膜炎、肾功能障碍、神经系统异常、血球计数异常、免疫系统异常、抗核抗体(Anti-nuclear Ab,ANA)阳性;只要在以上11项中出现四项以上即符合SLE的诊断。

There was a doubling in risk of lymphoma in new onset cases of inflammatory polyarthritis.

新发炎性多发性关节炎病例发生淋巴瘤有双倍的风险。

METHODS: 2105 subjects with new onset inflammatory polyarthritis were recruited to the Norfolk Arthritis Register and followed annually for 8.4 years.

新发炎性多发性关节炎的2105例受试者被招聘到诺福克关节炎登记处和每年调查一次跟踪调查8年。

OBJECTIVE: To determine the risk of lymphoma in a primary care derived cohort of new onset cases of inflammatory polyarthritis and assess the contribution of disease severity and standard immunosuppressive treatment.

目的:明确初级护理中新发炎性多发性关节炎病例组淋巴瘤的风险和评估疾病严重性和标准的免疫抑制治疗的贡献。

Objective To furnish an experimental basis of the early effects of rheumatoid arthritis on the temporomandibular joint by observing the histopathological changes of TMJ in the early stage of polyarthritis rats.

目的 观察大鼠多发性关节炎(polyarthritis,PA)早期颞下颌关节(temporomandibular joint,TMJ)的组织病理学变化,为研究类风湿关节炎(rheumatoid arthritis,RA)早期对TMJ的影响提供实验依据。

Polyarthritis model was induced by Freund's complete adjuvant in rats. The edema degree of the inflamed paws general affection T lymphocyte proliferation function, IL-1 activity secreted by celiac macrophage, peroxide lipid and SOD-1 in serum were detected.

用弗氏完全佐剂造成大鼠多发性关节炎,观察足跖肿胀程度、全身病变、脾脏T淋巴细胞增殖功能、腹腔巨噬细胞白介素 1(IL-1)分泌活性、血清脂质过氧化和超氧化物歧化酶(SOD-1)活性。

In the normal rats (n=5、6), CGRP-LI were mainly present in small and some medium-sized neurons and the primary afferent fibers and ter- minals in laminae Ⅰ,Ⅱ,Ⅴ,Ⅹ and Lissauer's tract of the spinal cord; GAL- and SP-LI were mainly present in small neurons and the superficial layers of the dorsal horn. After the adjuvant injection both CGRP-and SP-LI were in- creased corresponding to the development of arthritis. On day 2, CGRP-and SP-LI were moderately increased in laminae Ⅰ,Ⅱ and the posterior commis- sure of the spinal cord and small neurons in DRG, while SP was obviously in- creased in the superficial layers and DRG. On day 14, CGRP-LI were marked- ly enhanced in the above regions with the development of polyarthritis. Some- times many strongly stained long fibers could be seen in the posteriot commis- sure.

在DRG中,CGRP主要分布于小和中等神经元之中,SP和GAL主要分布于小神经元之中;2、注入弗氏完全佐剂(含冻干结核菌0.5mg)后第2天动物(各5~6例)产生具有明显红、肿、热、痛和痛敏的急性关节炎,免疫组化实验观察到注射侧脊髓背角和DRG中CGRP-和SP-LI明显增加;在佐剂后第14天,动物患肢肿胀、痛敏和自发痛均进一步加重,部分动物健肢也出现红肿,产生多发性关节炎时,脊髓背角浅层和DRG中CGRP-和SP-LI增加更为明显,并且在灰质后联合中可见许多深染的CGRP-LI长纤维;在佐剂后第21和28天,随着佐剂性关节炎的逐渐恢复,脊髓背角和DRG中CGRP-和SP-LI也接近正常。

Anyhow, acute wind damp and hot can have 5 main show such as the Quan Xinyan, much arthritis that send a gender, annular erythema, hypodermic brief summary and dancing disease.

总之,急性风湿热可有全心炎、多发性关节炎、环形红斑、皮下小结和舞蹈症等五个主要表现。

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