多中心的

Fractural theory has became a hot spot in current city geography studies for it can well reveal current situation and evolvement law of urban group.

1引言城市群是由若干个在地域上相连的不同等级规模，不同功能的城市组成的，各城市之间在各方面密切联系的多中心城市体系[1]。

Methods: This randomized, double-blind, placebo-controlled multicenter trial assessed the efficacy and tolerability of adjunctive treatment with levetiracetam 3,000 mg/day in adolescents (12 years) and adults (65 years) with idiopathic generalized epilepsy, who experienced myoclonic seizures on 8 days during a prospective 8-week baseline period, despite antiepileptic monotherapy.

本研究采用随机、双盲、安慰剂对照的多中心研究方式，评价在患有特发性全身性癫痫，虽抗癫痫治疗，仍在治疗后的8星期基线期内有8天为肌阵挛性发作的青少年（12岁）和成年（65岁）中使用左乙拉西坦3000mg/天作为辅助治疗的效果和耐受性。

FDA approval was based on data from a multicenter, double-blind, randomized clinical trial in which 72 patients received 1 of the 2 formulations in each nasolabial fold. Results showed that 93% of patients reported less procedural pain when treated with the lidocaine-containing dermal filler compared with the original version.

FDA的核准是根据一个多中心、双盲、随机临床试验，有72个病患在两侧的法令纹分别接受这两种配方之一；结果显示，93%的病患指出，使用含有lidocaine的皮肤注入器时，在疗程中比较少疼痛。

Daily supplementation with vitamins C and E starting between 9 and 16 weeks' gestation did not reduce the rate of pregnancy-associated hypertension, according to a large multicenter trial in low-risk, nulliparous women published in the April 8 issue of the New England Journal of Medicine.

据4月8日发表于《新英格兰医学杂志》(New England Journal of Medicine)上的一项对低风险的初产女性进行的大规模多中心临床试验结果，从妊娠9~16周开始每日补充维生素 C 和维生素 E 并未降低受试者妊娠相关高血压的发病率。

In conclusion,the data from the recent trials have shown promising clinical benefits of short-term advantages as well as long-term oncologic equivalence for laparoscopic surgery for mid-low rectal cancer.

最新的临床研究结果肯定了腹腔镜在中低位直肠癌外科治疗中的应用价值，显示了乐观的前景，但其临床应用仍需多中心前瞻性随机对照研究数据的支持。

Focus on research work and clinical studies in musculoskeletal oncology, especially about mechanism and biological therapy of osteosarcoma, such as proteomics studies of osteosarcoma, prospective control study of osteosarcoma, registration system of musculoskeletal oncology and genic tests about the familial inheritance osteoenchondroma, etc.

拟开展《骨肉瘤特异性相关抗原的蛋白质组学研究》、《骨肉瘤多中心前瞻性随机对照研究》、《骨与软组织肿瘤注册-会诊-随访登记系统》、《多发性骨软骨瘤家族遗传性基因的检测》等课题的相关研究工作，承担国家、省级和市级重大项目等课题的申报。

Then a complete porphyroblast was formed.

初期石榴石、十字石等呈细片状绿泥石、云母等假象，它们组成多结晶中心的网状集合体，接着进一步聚合生长，逐渐连成一片，成为变斑晶的骸晶，然后形成完整的统一的变斑晶，再在此基础上层圈式增生。

The ANRS 116 SALTO trial, a prospective, open-label, multicenter trial conducted in France, enrolled 99 patients, 63 of whom were men. At 24 months, 88% of patients (95% CI, 80 ??93) did not meet study criteria to reinitiate HAART: a decrease in CD4 cell count to 300 cells/弮L or the occurrence of an AIDS-defining event. More than three quarters (77%) did not resume HAART. Statistical analysis indicated that HIV- DNA level, CD4 nadir, CD4 at HAART initiation, CDC stage, and HIV risk category were significant risk factors for HAART reinitiation.

ANRS 116 SALTO试验则是法国的一个前溯式、开放标记、多中心试验，包含99位病患、63位是男性，24个月时，88%的病患(95% CI， 80 – 93)未达重新启动HARRT的研究规范：CD4细胞计数降低至 300 cells/μL 或者出现AIDS相关事件，超过四分之三(77%)未恢复 HAART；统计分析指出HIV-DNA值、CD4最低值、HAART开始时之CD4值、CDC分期、HIV 风险分类都是HARRT重新启动的显著风险因素。

Lotan Shilo and a team at the Sapir Medical Center in Tel Aviv University found that six volunteers slept less well after a cup of caffeinated coffee than after drinking the same amount of decaf. On average, subjects slept 336 minutes per night after drinking caffeinated coffee, compared with 415 minutes after decaf. They also took half an hour to drop off4—twice as long as usual—and jigged around in bed twice as much.

特拉维夫大学的塞帕医学中心的Lotan Shilo和一个小组发现六个志愿者在喝了一杯含咖啡因的咖啡后平均每晚睡336分钟，而喝完脱咖啡后平均每晚睡415分钟，他们用半个小时才能睡着——比平常长一倍，而且翻来覆去的时间比平常多一倍。

Lotan Shilo and a team at the Sapir Medical Center in Tel Aviv University found that six volunteers slept less well after a cup of caffeinated coffee than after drinking the same amount of decaf. On average, subjects slept 336 minutes per night after drinking caffeinated coffee, compared with 415 minutes after decaf. They also took half an hour to drop off4—twice as long as usual—and jigged around in bed twice as much.

特拉维夫大学的塞帕医学中心的Lotan Shilo和一个小组发现六个志愿者在喝了一杯含 7 新东方在线 2009 职称英语强化班网络课堂电子教材系列阅读理解中文朗读咖啡因的咖啡后平均每晚睡336分钟，而喝完脱咖啡后平均每晚睡415分钟，他们用半个小时才能睡着——比平常长一倍，而且翻来覆去的时间比平常多一倍。

I didn't watch TV last night, because it .

昨晚我没有看电视，因为电视机坏了。

Since this year, in a lot of villages of Beijing, TV of elevator liquid crystal was removed.

今年以来，在北京的很多小区里，电梯液晶电视被撤了下来。