外毒素

Diphtheria toxin is an exotoxin secreted by Corynebacterium diphtheriae that has been lysogenized by β bacteriophage that carries the DT gene.

白喉毒素是棒状白喉杆菌被β噬菌体感染后分泌的一种外毒素。

According to this, we take the lead in putting forward the new strategy possessing original innovation and independent intellectual property which is by using molecular design and expression of brand new types of B7PE40KDEL recombinant exotoxin fusion proteins to specifically prevent GVHD or HVG Effect.

据此，我们率先在国际上提出了分子设计并研创全新型系列重组人B7-PE40KDEL外毒素融合蛋白以达到特异性防治GVHD和HVGD，诱导免疫耐受的新思路。

Methods Three-dimensional gels of type I collagen containing rabbit keratocytes were incubated in the presence of different concentrations of exotoxin A (0.1,1.0,10 mg·L-1),cultivated for 24 h at 37℃, the change of keratocytes in morphology was observed under the light microscope,and the amount of lactate dehydrogenase was measured by enzyme linked immunosorbent assay.

含兔角膜基质细胞（1×105·mL-1）三维胶原凝胶表面添加提纯的不同浓度绿脓杆菌外毒素A（0.1、1.0和10 mg·L-1）后，放入无血清MEM培养液中37℃培养24 h，采用光学显微镜观察培养的兔角膜基质细胞形态学变化，采用酶联免疫吸附法检测损伤的兔角膜基质细胞释放的乳酸脱氢酶含量。

RESULTS We successfully obtained human caspase-3 gene, the genes and expression vectors of reversed caspase-3 and its fusion protein with part of the translocation domain of Pseudomonas exotoxin A. Compared with the control group, the expression of both genes caused in a similar degree the decrease of living cell numbers and massive occurrence of apoptosis.

结果成功获得了caspase-3基因，构建了重构型caspase-3基因和重构型caspase-3与绿脓杆菌外毒素转膜结构域部分肽段的融合蛋白基因及其表达载体，与对照组相比，在转染后1～4 d内，两种基因的表达均导致HeLa细胞存活数减少，大量细胞发生凋亡，且二者活性相当。

In order to obtain the novel recombinant exotoxin fusion protein B7-PE40KDEL and to further explore the mechanisms of proliferation, differentration and related signaling transduction regulated by B7-1 and B7-2, their extracellular region cDNA were obtained via PCR.

为了研创B7-PE40KDEL新型重组外毒素融合蛋白，同时也为今后更深入地探讨B7-2和B7-1分子在调控T细胞增殖、分化及相关信号传导过程中的作用，本研究首先通过PCR克隆获得了含编码人B7-2和B7-1分子胞外区的cDNA。

The secretion of δ-hemolysin well reflects the regulation of access gene regulation system in S. aureus.

δ溶血素的分泌反映了金黄色葡萄球菌密度感应系统调控外毒素分泌的特点。

Enteroscopy was performed in 3 patients,and some typical pathological changes were discovered in sigmoid colon and rectum.

抗生素相关性肠炎是难辨梭状芽胞杆菌的外毒素所致的结肠和小肠粘膜的急性坏死炎症，并在坏死的粘膜上形成伪膜[1]。

An administrative core unit will be set up with missions of taking care of all the exter

综合而言，以这样一个高度整合的研究计画，从临床、实验及治疗的方向在病人、细菌、细胞层次、和分子层次作系统性的研究，探讨热原性外毒素B及其他致病因子的功能，将会有助於我们对於A群链球菌的致病作用进一步了解，更重要的是这些资讯将会提供临床治疗的新策略。

The biological effect of pUCP18/lasR was detected by RT-PCR, NAD method and the assay of pyocyanin.

RT-PCR检测LasB基因和LasI基因mRNA的表达，NAD法测定外毒素A的活性，紫外分光光度计测定绿脓菌素的产生水平。

the botulism toxin is the bacillus botulismus produces exotoxin, for present known toxin toxicity strongest.

肉毒毒素中毒致呼吸骤停，经心肺复苏抢救成功一例肉毒毒素是肉毒杆菌产生的外毒素，为目前已知毒素中毒性最强的。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。