外显子

Antigene peptide nucleic acid specifically inhibits MYCN expression in human neuroblastoma cells leading to cell growth inhibition and apoptosis Roberto Tonelli,Stefania Purgato,Consuelo Camerin,Raffaele Fronza,Fabrizio Bologna,Simone Alboresi,Monica Franzoni,Roberto Corradini,Stefano Sforza,Andrea Faccini,Jason M. Shohet,Rosangela Marchelli,and Andrea Pession Department of Pediatrics, University of Bologna,Sant'Orsola-Malpighi Hospital, Bologna, Italy; Department of Organic and Industrial Chemistry, University of Parma, Parma,Italy; and 3Center for Cell and Gene Therapy, Texas Children's Cancer Center, Baylor College of Medicine, Houston, Texas Abstract We developed an antigene peptide nucleic acid for selective inhibition of MYCN transcription in neuroblastoma cells, targeted against a unique sequence in the antisense DNA strand of exon 2 of MYCN and linked at its NH2 terminus to a nuclear localization signal peptide.

抗原肽核酸抑制MYCN具体表达的神经母细胞瘤细胞，导致细胞生长的抑制和凋亡罗伯托利，斯特凡Purgato ，苏埃洛卡默琳，拉菲尔Fronza ，梅奥尼博洛尼亚，西蒙娜Alboresi ，莫妮卡弗兰索尼，罗伯托Corradini ，斯特凡诺斯福尔扎，安德烈Faccini ，杰森先生Shohet ， Rosangela Marchelli ，和安德烈Pession儿科，博洛尼亚大学，圣' Orsola -马尔皮基医院，博洛尼亚，意大利；有机部和工业大学化学帕尔马，帕尔马，意大利和3Center的细胞和基因治疗，德州儿童癌症中心， Baylor医学院，得克萨斯州休斯敦摘要我们开发了一种抗原肽核酸的选择性抑制神经母细胞瘤MYCN转录细胞，针对一个独特的序列反义DNA链的第2外显子，并与在MYCN 其氨基端为核定位信号肽。

Deletion of exon 5, 8 was observed in cutis primary T cell lymphoma and no mutation was found. The abnormality may play a role in the pathogenesis of the cutis primary T cell lymphoma.

原发性皮肤T细胞淋巴瘤中存在FHIT基因外显子5和8的异常缺失，这种异常转录可能与该病的发生有关。

Methods The deletion and mutations of exon5, 8 of FHIT gene were detected in 10 cutis primary T cell lymphoma samples tissues by polymerase chain reaction and single-strand conformation polymorphism methods.

用PCR-SS-CP法检测了10例原发性皮肤T细胞淋巴瘤患者皮损FHIT基因外显子5和8的缺失和突变状况，10例健康皮肤组织做对照。

(1) Exon 6,7,8 have no relation with the susceptibility of HCV infection. The genetic basis of the four amino acids is highly conserved in Chinese population. Because other sites of CD81 protein are highly conserved among species, there is no or very rare polymorphism of CD8I in Chinese people.(2) The susceptibility of HCV infection has nothing to do with the genetic basis of the ligand binding region of LDLR.Postgraduate DongQiumingDirected by Professor Gao Jinsheng Professor Lu Daru

（1）CD81外显子6、7、8与HCV感染的易感性无关，以上四个氨基酸的遗传基础在中国人中是高度保守的；由于CD81蛋白的其它位点在种间是高度保守的， CD81，LDLR单核菩酸多态拄与丙型肝炎病毒感染易感性的相关性研究摘要因此，在中国人群中 CDSI蛋白的多态性稀少或不存在。u）HCV感染的易感性与LDLR的配体结合结构域的遗传基础无关。

In principle, approximately 80% of all DMD patients could be treated with exon–skipping drugs.

原则上，大约有80例DMD％可以治疗外显子跳跃的药物。

HCN4 is as wrong as all sorts of rhythm of the heart the relationship is close, familial sex Dou Xingxin has eaten the transmissibility rhythm of the heart such as delay show outside gene of wrong patient HCN4 child alkaline base be short of break or the change that bump changes mutation to bring about HCN4 passageway albumen, cause If extent to decrease, belong to euchromosome dominance heredity.

HCN4和各种心律失常关系密切，家族性窦性心动过缓等遗传性心律失常患者HCN4基因外显子碱基的缺失或颠换突变导致HCN4通道蛋白的改变，引起If幅度减少，属于常染色体显性遗传。

Objective To explore the variation of the exon 11 of MEF2A gene in patients with acute myocardial infarction.

目的 研究MEF2A基因第11外显子在普通急性心肌梗死患者中的变异情况。

So origin and evolution of exon is an important question in evolutionary biology.

因此研究新外显子的起源与进化也是十分重要的进化生物学的领域。

The results showed that there were SSCP change of ASSC subunit gene exon 12 in 3 cases.

结果在原发性高血压患者中检出了3例有ASSCβ亚单位基因第12外显子突变的个体。

And the AT- contents of exon will be presented in the experiments.

并用试验说明了关于外显子中AT含量的问题。

However, as the name（read－only memory）implies, CD disks cannot be written onorchanged in any way.

然而，正如其名字所指出的那样，CD盘不能写，也不能用任何方式改变其内容。

Galvanizes steel pallet is mainly export which suits standard packing of European Union, the North America. galvanizes steel pallet is suitable to heavy rack. Pallet surface can design plate type, corrugated and the gap form, satisfies the different requirements.

镀锌钢托盘多用于出口，替代木托盘，免薰蒸，符合欧盟、北美各国对出口货物包装材料的法令要求；喷涂钢托盘适用于重载上货架之用，托盘表面根据需要制作成平板状、波纹状及间隔形式，满足不同的使用要求。