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The results show that firstly, ApoE and LDL receptors can be transported bidirectionally (i.e. retro-and anterogr-adely) in the axoplasm along axons. Secondly, ApoE derived from regenerating fillers can be transported re t rogradely to the cell bodies.

本文用免疫细胞化学法研究正常和再生的大白鼠外周神经中脱辅基脂蛋白E和低密度脂蛋白受体的运输特性,发现在正常的外周神经中,ApoE及LDL受体在轴浆中均可沿轴突正行和逆行运输;再生的神经可产生ApoE,ApoE可逆行向细胞体转运。

The lesion, the changes of activity of cholinesterase and acid phosphatase of motor neurons in lateral nucleus of spinal cord anterior horn, the function of axoplasm transportation and nerve conduction, the regeneration of axons and myelin sheath, and the recovery of sciatic nerve function were examined at 7, 14, 30 and 90 days intervals after operation, using Nissl and enzyme histochemistry staining, electrophysiological technique, hydrogen-peroxide oxidoreductase retrograde trace method, axon image analysis, and measurement of sciatic function index. The spinal cord anterior horn of injury side was compared to the correspondence region of spinal cord.

分别于术后7、14、30和90d应用酶组织化学方法、电生理方法、HRP (hydrogen-peroxide oxidoreductase)逆行示踪方法、轴突图象分析方法以及坐骨神经功能指数(sciatic nerve function index,SFI)测量等方法检测坐骨神经损伤后对应脊髓神经元的存活率、神经元胞体酶系变化、损伤神经在轴浆运输、电传导以及轴突、髓鞘再生等方面的恢复情况,探索外周神经损伤后OECs及几丁质对神经元的保护作用以及对新生神经功能恢复的作用,为外周神经损伤的治疗提供新的理论基础。

Functional recovery after hemisection injury improved significantly in the late postoperative period with transplantation of preconditioned peripheral nerve.

半切损伤后移植预先处理的外周神经的术后晚期功能恢复要明显好得多。

Figure 2 Cranial nerve susceptibility in superficial siderosis of the central nervous system in relation to glial length. Relative length of the glial and peripheral segments of each cranial nerve. Open bar, peripheral nerve; closed bar, glial component. Adapted from Tarlov 1937

图2。 中枢神经系统表面含铁血黄素沉积症中颅神经的易感性与神经胶质长度有关,下图显示了每条颅神经中心部分神经胶质长度与外周组成部分的相对比例。

The effective stimulating sites were indentified by defensive cardiovascular response and other components of defence reaction evoked by 3 s trains of rectangular cathodal pulses (100Hz, 0.5ms pulse duration, 70 -150μA intensity for dPAG and 150-250μA for PF) delivered from a programmed multichannel constant current stimulator. The responses included an increase in blood pressure and heart rate, pupillodilation and an increase in the rate and depth of respiration. Currents of 1Hz, intensity of 100- 150μA for dPAG and 200-250μA for PF were used to observe the effect of the stimulation of them on RVLM neurones. The deep peroneal nerve and superfacial deep peroneal nerve were carefully separated, and put on a pair of stimulating electrode respectively, Both nerves were stimulated with constant rectangular pulses of 1Hz, 0.5ms duration and 300μA current intensity to see their effects on RVLM neurones. The baro-and chemo-receptors were activated by the intravenous injection of phenylephrine or 0.208 M NaH2PO4. The degree of convergent inputs to individual RVLM neurone was studied by the stimulation of the sites mentioned above. It was found that neurones about 61.4%(27/44) and 35.3%(6/17) received convergent inputs from three and four places respectively.

过去的研究主要集中于整体水平,利用电刺激或化学刺激RVLM神经元,观察对血压、心率及交感活动的影响,并对影响心血管交感活动的神经递质进行了广泛探讨,积累了大量资料;在神经元水平,主要研究刺激脑内核团、外周神经、化学感受器及压力感受器等对RVLM神经元放电的影响和某些神经递质影响神经元活动的机制、然而,对RVLM神经元如何整合不同信息、其可能突触机制等研究得较少,本互作拟采用在体细胞内、细胞外记录电活动与微电泳,结合中枢核团及外周神经电刺激等方法,对RVLM神经元在不同状态下的整合作用规律与可能机制进行初步探讨,为进一步了解这一复杂的整合过程提供新的理论依据。

Electropuncture not only can improve damaged symptoms of peripheral nerve but also relieve pain by stimulating central nerves, which may be the cause why electropuncture had better effect on enhancing mechanical pain threshold of rats operated side.

电针不仅可以改善外周神经的损伤症状,同时还通过刺激中枢神经的机制达到镇痛作用,此模型中大鼠术侧机械痛阈改善方面电针优于单纯针刺,这可能就是电针作用的一个方面。

Recently, compression of peripheral nerve roots due to enlarged epidural venous plexus has been described as a possible cause of back and radicular pain, too.

近来,由于硬膜外静脉丛曲张导致外周神经根的压迫也被认为是引起背痛和神经根痛的一个可能的原因。

The study suggested that TNF〓 and IL-1〓 might be produced in the cascade of events resulting in Wallerian degeneration and hyperalgesia following peripheral nerve compression, and increased TNF〓 and IL-1〓 mRNA may trigger other later responses in nervous system contributing to the initiation of peripheral neuropathic pain or other degeneration/regeneration processes.

提示:外周神经受压后诸如华勒氏变性、痛觉过敏等一系列反应可能有TNF〓和IL-1〓的产生,而后者的增加又会启动其它神经反应而在外周神经源性痛形成和神经退变/再生中发挥作用。

Peripheral nerve injury induced by mechanical trauma, ischemia, metabolic abnormality or local inflammation can lead to chronic pain symptoms, including hyperalgesia, allodynia, spontaneous pain and paraesthesia.

机械性外伤、缺血、机体代谢异常以及局部炎症等各种致病因素可直接或间接引起外周神经的损伤,诱发以痛觉过敏、痛性感觉异常、自发性疼痛及感觉倒错为主要表现的持久异常痛感觉,称之为慢性痛。

However, surprisingly little is known about the role of Notch in the development and pathology of Schwann cells and peripheral nerves.

但,关于Notch在雪旺氏细胞和外周神经的发育及病理学中的作用,我们了解的却非常少。

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