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The protein interaction domains was delineated at the N-terminal 50-amino-acid fragment of HCV core protein and the C-terminus of p53. Confocal analysis also revealed that these two proteins colocalize in subnuclear granules and peri-nuclear region. Transfection experiments using a p53-responsive reporter plasmid in HuH-7, Hep3B, HepG2 and H1299 demostrated that full-length HCV core protein could elicit a positive or negative effect on the p53-mediated transcriptional activation depending on the concentration of the HCV core protein.

更且利用p53蛋白C端删除55-95个胺基酸之质体与含p53蛋白结合区之报导基因和表现全长HCV核心蛋白三者之质体於H1299细胞株进行共同转染时,与全长p53蛋白比较,发现HCV核心从增强全长p53蛋白之转活化能力转为抑制p53蛋白缺乏C端55-95个胺基酸之转活化能力,因实验室已有结果证实活体外及活体内缺乏C端55个及75个胺基酸之p53蛋白无法与HCV核心蛋白进行结合(Kao, unpublished data)。

The beam stirrups are very important to the anchorage of the upper longitudinal bar in the beam outside the wall s width.

节点区的宽梁箍筋对于凸出在墙外的宽梁上部纵筋的锚固具有比较重要的作用。

During a nuclear accident, all the highways railways and seaways that cross through the exclusion zone must be blockaded immediately in order to control the nuclear accident and dispersal.

核子事故发生时,对於通过禁建区之公路、铁路或水路得随时封锁,以便专供处理核子事故及疏散之用外,并应立即通知当地治安机关。

All three exons including splice sites were screened. Results Two of the 25 patients with advanced retinopathy of prematurity showed point mutation in the non-read frame of the third exon of the ND gene. Similar analyses of the first and second non region failed to detect additional mutation, including splice bites. None of the controls resealed similar mutation.

结果 2例患儿的第3外显子的非读码框架基因序列经银染后可见2条异常条带出现,并经直接测序验正发生基因的点突变由T到C,而外显子1及2以及其剪接区均未发现突变对照组未发现相同突变。

So far apart from perimmon cakes, little has been done on the factory processing ofpersimmon products, Through extensive studies, this paper suggests a new way to developand utilize persimmon tree resources and a series of wheat meal with persimmon and persim-mon tea processing technology.

但至今除柿饼外,还没有大量的工厂化柿子加工品,通过研究提出了柿树资源开发利用的途经及麦饭石柿子系列加工品和麦饭石柿叶茶的加工工艺流程,在乾县柿区建立柿子系列食品和饮料加工厂,具有广阔发展前景。

By calculating, we can see that the first thick-walled cylinder in the wall to reach the plastic, and then a gradual outward expansion of plastic zone, which can be practical for engineering design, production and application of the provision of meaningful reference value.

通过计算可知,厚壁圆筒在内壁最先达到塑性,而后塑性区逐渐向外扩展,这可为工程实际中的设计,生产和应用提供有意义的参考价值。

With equidistance sampling, the research takes 13 soil samples in 0-20cm of each site from the middle of a chosen typical shrub named plateau red willow every other two meters, in Hongyuan county of Sichuan province, and analyzes the character of these soil samples.

以川西北高原红原县为研究区,用等距离取样法,在高寒沙化地中选择一典型的灌丛高原红柳,从灌丛根部开始每隔2米向外选点取0-20 cm土样13个,并分析了这些土样的土壤性状。

Membranes was discovered. PIXE scanning was carried on the 7th cun of a case of

织切片上,观测了胆经的外丘,光明,阳辅,悬钟等穴区的血管分布特点

He then discovers that the practice area is not out of bounds.

然后他发现练习区并不是界外。

When the pitcher throws to the batter, it is a strike if he swings and misses, if he hits the pitch into foul territory, or if he does not swing at a pitch in the strike zone.

当投手把球投向击球员后,如果击球员挥捧而未击中,把球打入界外地区或球在好球区之内而来挥棒击球,都算是一击。

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Fancy gold-plated dangling earrings with facetted White Opal crystals.

花式镀金悬垂耳环与facetted白欧泊水晶。

This essay chooses the study aim from biology teachers in middle school in Shi Jiazhuang which tells us that most of the middle school biology teachers in Shi Jiazhuang have the"burnout", lower successfulness, individualize.

本文选取石家庄市初中生物教师作为研究对象,运用问卷调查的方法对石家庄市初中生物教师职业倦怠的现状进行调查,调查结果发现,石家庄市初中生物教师这一群体普遍存在职业倦怠,情感枯竭程度偏高,成就感偏低,去个性化程度最为严重。

In measurements of a day,generallyspeaking,the photosynthesis of birch in mesophytic habitat is better than that in xerophytichabitat(peak values are 12.8,10.33μmolCO2m-2s-1 respectively);that of sexual birch inmesophytic habitat is better than that of clone birch(peak values are 9.87,6.71μmolCO2m-2s-1respectively);that of young tree is better than that of seedling(peak values are12.37,10.05μmolCO2m-2s-1 respectively).

在一天中的各个时刻,总体说来,中生生境生长的白桦光合作用超过旱生生境生长的白桦光合作用(净光合速率峰值分别为12.8、10.33μmolCO2m-2s-1);白桦幼树的光合作用超过白桦幼苗(净光合速率峰值分别为12.37、10.05μmolCO2m-2s-1);中生生境有性白桦的光合作用超过无性白桦的光合作用(净光合速率峰值分别为9.87μmolCO2m-2s-1、6.71μmolCO2m-2s-1)。