增溶

Novel chitosan derivative with long alky groups as the hydrophobic moieties and carboxymethyl groups as the hydrophilic moieties was synthesized. The chemical structure of N-octyl-O, N-carboxymethyl chitosan was characterized via FTIR, 1H NMR and elemental analysis. The physical properties were analyzed with wide angle X-ray diffraction and differential scanning calorimetry.

以天然可生物降解的壳聚糖为原料，通过在壳聚糖6位羟基上引入羧甲基，在2位氨基上引入疏水烷基链，制得N-辛基－O，N-羧甲基壳聚糖两亲性衍生物，分别用FTIR、1H NMR和元素分析等技术对其结构进行表征，用广角X射线衍射和差示扫描量热法对具物理性质进行分析，并考察其在各种溶剂中的溶解性能及其对难溶性药物的增溶能力。

However,after addition a little apolar molecules,apolar molecules insert into hydrophobic microdomains,which makes PPO chains extend at certain degree,and the order of LLC increases.Therefore,the systems will supply favorable conditions for enhancing the solubility of oil-soluble molecules,which further expands application prospects of the systems.

而加入少量极性较小的油溶性分子后，油溶性分子填充到PPO链段间，使得PPO链段在一定程度上得到伸展，液晶层间距增大，两亲分子排列的有序性增强，这就为油溶性分子的增溶提供了有利条件，扩展了该体系的应用前景。

The solubilities in some solvents were investigated and solubilization abilities of OCC for water-insoluble drugs were evaluated. The results show that the degree of substitution of carboxymethyl groups and octyl groups are determined to be 115.9% and 58.0%, respectively. OCC are insoluble in organic solvents while show a much better solubility in water and formed opalescence solutions, which increased the solubility of paclitaxel up to 500 folds in water. The drug loading and drug encapsulation efficiency of OCC are 34.6% and 89.9%, respectively.

所制备的OCC羧甲基取代度为115.9%，取代主要发生在6位羟基上；辛基取代度58.0%，取代主要发生在2位氨基上；与壳聚糖相比，OCC分子间／内氢键作用减弱；OCC在常用的有机溶剂中不溶，但在水中溶解度增加，能够形成具有淡蓝色乳光的纳米胶体溶液，对难溶性抗肿瘤药物紫杉醇具有优越的增溶能力，使紫杉醇在水中的溶解度提高近500倍，载药量34.6%，包封率为89.9%。

Aim To investigate the combined effect of cosolvent and cyclodextrin on solubilization of insoluble drugs.

目的 研究潜溶剂和环糊精对难溶性药物的联合增溶作用。

The validated mathematical model can be used to explain and predict the combined solubilization of the two insoluble drugs in different cosolvent systems.

该数学模型可以用于解释和预测潜溶剂和环糊精对难溶性药物的联合增溶作用。

Fluorescence probe study, surface tension and dye solubilization test indicate the watersoluble calixarene, 5, 11, 17, 23, 29, 35, 41, 47-octosulfonato-49, 50, 51, 52, 53, 54, 55, 56octododecyloxycalix [8] arene (1〓-C〓) acts as"unimolecular"micelle in water.

荧光探针、表面张力及染料增溶实验表明，水溶性杯芳烃5，11，17，23，29，35，41，47-octosulfonato-49，50，51，52，53，54，55，56-octododecyloxycalix[8]arene（1〓-C〓）在水溶液中以单分子胶束的形式存在。

In detail the process of the invention relates to a method for solubilising an oil-soluble pigment into an oil or fat by extraction of a solid preparation containing the oil-soluble pigment comprising the steps of a mixing the solid preparation containing the pigment with water, an extraction medium containing an edible oil or fat, and a nonionic surfactant having a hydrocarbyl group, an acyl group or a substituted hydrocarbyl or acyl group containing at least 6 carbon atoms; b optionally centrifugalize the mixture obtained and separate the oil phase.

具体而言，本发明方法涉及一种通过萃取含有油溶性颜料的固体制剂而使油溶性颜料在油或脂肪中增溶的方法，其包括步骤a将含有颜料的固体制剂与水、含有食用油或脂肪的萃取介质以及具有含至少6个碳原子的烃基、酰基或取代烃基或取代酰基的非离子表面活性剂混合，和b任选将所得混合物进行离心并且分离油相。

The reason is probably that the aggregates with low aggregation number start to form at~I, which are not capable to solubilize water. Water solubilization starts only when the aggregation number of reverse micelles is high enough, which occur at~W, the concentration is much higher than~I.

可能因为碘光谱法测得的是开始发生聚集时的cmc，这时聚集体较小，对水无增溶能力；只有当聚集体随浓度升高而长大到一定程度时，才能开始增溶水。

Results of the studies have comfirmed that surfactants cause the NAPLs to desorb from soil strongly and enhances the transferability of NAPLs through soil by improving their dissolution in liquid and fluid ability in soil. So the efficiency of pump-treat method can be improved by the surfactants.

大量研究表明，表面活性剂能促进NAPLs从土壤颗粒中解吸，并通过增溶和增流作用改善NAPLs在土壤中的溶解和迁移能力，进而提高抽出处理法的去除效率。

The soluble pentosans in dough increased with the addition of Pentopan, the maximum extent of solubilization occurred at the end of kneading. Soluble pentosan contents in doughs treated with the enzyme at the two different levels were similar.

戊聚糖酶使面团中可溶性戊聚糖含量比原料面粉中的显著增加；增溶速率最快的是在和面阶段；在上述的两个加酶水平下，面团中戊聚糖的增溶程度相当。

On the other hand, the more important thing is because the urban housing is a kind of heterogeneity products.

另一方面，更重要的是由于城市住房是一种异质性产品。

Climate histogram is the fall that collects place measure calm value, cent serves as cross axle for a few equal interval, the area that the frequency that the value appears according to place is accumulated and becomes will be determined inside each interval, discharge the graph that rise with post, also be called histogram.

气候直方图是将所收集的降水量测定值，分为几个相等的区间作为横轴，并将各区间内所测定值依所出现的次数累积而成的面积，用柱子排起来的图形，也叫做柱状图。