增殖体

Result 1 Magnetic nanoparticles, magnetic nanoparticles modified with antisense oligodeoxynucleotide of human telomerase reverse transcriptase induced HL-60 tumor cells to apoptosis, we could see typical morphologic change of apoptosis cells: karyopyknosis, chromation"s condensing and aggregation in nuclear, forming crescent-shaped or annulus structures to lean on edge of cell nucleus"s membrane and posing apoptosis body by Atomic Force Microscope, Fluorescence microscope, transmission electron Microscope 2 There was a significant difference compared with control group(p.01), inhibition ratio had significant positive correlation with medication dosage and time ;during 0.8-8μM dosage amplitude, inhibition ratio accrescenced by dosages increasing. However, the inhibition ratio would decrease when dosage over 8-80μM.

结果 1 磁性纳米粒子、修饰有端粒酶反义寡核苷酸的磁性纳米粒子诱导HL-60细胞发生凋亡，原子力显微镜、光学显微镜、荧光显微镜和透射电镜下均观察到HL-60细胞呈现典型的凋亡细胞的形态变化：细胞核固缩，核内染色质浓缩、凝聚、形成新月形或环状结构紧靠在细胞核膜边缘，并形成凋亡小体。2 磁性纳米粒子、修饰有端粒酶反义寡聚脱氧核苷酸的磁性纳米粒子对HL-60肿瘤细胞的生长和增殖有明显的抑制作用，与对照组相比有显著性差异(p＜0.01)，在剂量为0.8-8μmol／L范围内，抑制率随剂量的增加而增加，当剂量超过8μmol／L时，抑制率反而下降；3 磁性纳米粒子、修饰有端粒酶反义寡聚脱氧核苷酸的磁性纳米粒子可增强p53基因的表达活性，引起DNA降解损伤，反向调节细胞周期活动，促使细胞从G0期进入G1期，抑制肿瘤细胞的生长。4 修饰有端粒酶反义寡聚脱氧核苷酸的量子点能通过内吞作用进入HL-60肿瘤细胞的细胞核，可以在细胞内进行定位和促进HL-60肿瘤细胞的凋亡。

The expression changes of relating-apoptosis gene proteins (bcl-2, bax) were detected by immunohistochemistry before and after treating with the Agaricus Blazei Murill extract to explore the possible mechanisms of inducing apoptosis for MGC-803 cells in vitro. Results: The Agaricus Blazei Murill extract significantly inhibited the proliferation of gastric cancer cells in vitro and the inhibitive effects were depended on the medicine concentration and treating times. After treating 24 hours on the gastric cancer cells with the morphologic changes of apoptosis with chromatin margination, karyopyknosis, karyorrhexis were found by the light.

结果：(1)通过细胞培养和MTT法，表明长白山姬松茸在体外对MGC-803细胞株有明显的抑制作用，加药组与对照组相比其生长抑制率有显著性差异(P＜0.01)，而且这种抑制作用呈现浓度和时间的依赖性；(2)通过集落形成率的测定结果表明，加药组与对照组相比其集落形成率和集落形成抑制率有明显差异(P＜0.01)，说明长白山姬松茸对MGC-803胃癌细胞株有明显抗增殖作用；(3)光镜观察结果表明，加药组可见细胞脱水浓缩伊红染色增强，胞体缩小，内含高度浓缩的胞核呈深蓝色等典型细胞凋亡形态；经AO／EB荧光染色观察结果表明，当终浓度为1.0mg／ml的姬松茸提取物作用于MGC-803胃癌细胞24h后，其凋亡率和破膜率与自然凋亡率与破膜率相比，均有显著性差异，其凋亡率86.3％(P＜0.001)，破膜率为41.6％(P＜0.01)，说明姬松茸确实有诱导MGC-803胃癌细胞凋亡的作用，同时也有细胞毒作用，但以诱导细胞凋亡为主；(4)免疫组化结果表明，用药前后凋亡相关基因的BCl-2、Bax蛋白均有显著性的改变(P＜0.001)。

Thus, it may serve as a novel target for the treatment of various skin disorders. Clinically, PPARgamma agonists have been used to treat psoriasis, psoriatic arthritis, atopic dermatitis, melanoma, hirsutism, vascular tumors and lipodystrophy.

临床上过氧化物酶体增殖因子活化受体γ激动剂已被试用于银屑病、银屑病性关节炎、特应性皮炎、黑素瘤、多毛症、血管肿瘤和脂肪营养不良等。

We examined the expression of the lipogenic tumor-related markers peroxisome proliferator-activated receptor γ, CDK4, and MDM2 in 15 cases of DDL and 45 cases of retroperitoneal/thigh UHGPS.

我们评价了15例DDL和45例腹膜后/大腿UHGPS表达以下3个脂肪源性肿瘤相关标记的情况：过氧化物酶体增殖物激活受体γ、CDK4和MDM2。

Results In Vero cell system,in direct virucidal and infection block experiments,fullerene C60 liposomes have induction effect on the expression of HSV-1F strain glycoprotein gC,whether it is under illumination or in lucifugal conditions,but in multiplication inhibition experiments,fullerene C60 liposomes have no effect to the expression of HSV-1F strain gC.

结果 在Vero细胞系统中，C60脂质体在直接杀灭和感染阻断的实验中，不论在光照还是在避光条件下，对HSV-1F株gC的表达均有诱导作用；但是在增殖抑制实验中，对HSV-1F株gC的表达没有影响。

Generally we think muscular histogenesis has many steps of biology, including foetal mesoderm merotomy; myoblast shapes in arthromera; myoblast can form muscular tissue to move to limbs; the proliferation of sarcoblast can increase cells\'quatity.

一般认为，肌组织发生是一多步骤的生物学过程，包括胚胎中胚层的分节；成肌细胞在体节形成；成肌细胞向四肢迁移形成肌组织；成肌细胞增殖以增加细胞数量。

Objective: To study the effect of paeonol on the proliferation rate and tissue plasminogenactivator in mesothelial cells.

目的：探讨丹皮酚影响下离体间皮细胞的增殖及分泌组织型纤溶酶原激活剂的情况。

Firstly, callus induction and subculture for Mikania micrantha were studied systematically. The research on callus induction showed that: Shoot tip has higher induction rate than other explants ; At 25℃ and dark regime, the callus was better cultivated on Murashige and Skoog medium (pH5.8) containing 2.0mg/L 2,4-D and 1.0mg/L KT.

首先，对微甘菊愈伤组织诱导和继代增殖培养进行系统研究，愈伤组织诱导研究表明：外植体中芽尖诱导率最高，在含2，4-D2.0mg／L、KT1.0mg／L、pH5.8的MS培养基上25℃黑暗条件下愈伤组织诱导效果较好。

In addition, the influences of BIS on the activities of lymphocytes in vivo and in vitro were studied, including the blast transformation of lymphocytes, the number of acid α-naphthyl acetate esterase positive lymphocyes, the cytostatic effect of hepatic LGL against hepatoma cells, in older to provided the most adequate scientific foundation for the best application of hepatoma immunotherapy.

此外还对上述不同免疫制剂在体应用对正常大鼠血淋巴细胞转化率及酸性非特异性酯酶阳性淋巴细胞数量的影响；不同免疫制剂对分离培养的肝大颗粒淋巴细胞抑肝癌细胞增殖的直接影响的研究，为肝癌免疫治疗的更佳选择提供更充分的科学依据。

The study was conducted on the experiment of explants sterilization of tissue culture of Photinia serru-lata stem segment,prevention of browning,proliferation culture and root induction and so on.

对石楠茎段组织培养中外植体的灭菌、褐变预防、增殖培养、根诱导等进行了试验研究。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。