增效作用

Changdong" showed a noticeable enhancive effect when it was co-administrated with other anti-tumor agents or when it was co-applied with radiotherapy. The action mechanism study showed that an apparent cytotoxic effect of "Changdong" on ten tumor strains in vitro with a quantity-effect relationship was observed. Immunity experiment showed that "Changdong" could induce proliferation of spleen lymphocyte in mice bearing tumor and could improve NK cell" s activity, whereas has no impact on IL-2" s reproduction. It was also noticed that "Changdong" could induce human liver cancer QGY" s apoptosis in vitro, and it happened mainly on G0-G1 phase.

结果："长动"对小鼠移植瘤模型和人体肿瘤裸鼠异种移植均有明显抑制作用，量效关系明显："长动"与放疗和化疗分别联合应用有明显的增效作用：作用机制研究结果：细胞毒性试验研究表明"长动"在体外对10株肿瘤细胞有明显的细胞毒性作用，量效关系明显；免疫学试验表明"长动"可以诱导荷瘤小鼠的脾淋巴细胞增殖，增强NK细胞的活性，对IL-2的产生无明显影响；"长动"在体外可明显诱导人体肝癌QGY细胞凋亡，使细胞阻滞于G0-G1期。

Five models were used to investigate the "Changdong"" s anti-tumor effect: mice S180 sarcoma solid model, mice liver cancer H22 solid model, mice Lewis lung cancer model, as well as human liver cancer QGY and colon cancer LOVO implanted in naked mice; mice liver cancer H22 was also used to evaluate the enhancive effect of "Changdong" when it was co-applied with other anti-tumor agent or with radiotherapy; The "Changdong"" s cytotoxic effect in vitro on such tumors as QGY, LOVO, lung cancer A549, breast cancer MCF-7, as well as mice leukemia P388 was observed through MTT method. And investigate the effect of "Changdong" on proliferation of spleen lymphocyte, on activity of NK cell and on synthesis of IL-2 in mice bearing Lewis lung cancer, respectively. With propidium iodide straining, cell aigptosis and cell circle were analyzed by flow cytometry. Result:"Changdong" has an evident tumor inhibitive effect on mice tumor model as well as human tumor implanted in naked mice with a quantity-effect relationship.

使用小鼠S180肉瘤、小鼠肝癌H22实体瘤和小鼠Lewis肺癌模型，以及人体肝癌QGY和人体肠癌LOVO裸鼠异种移植模型，进行"长动"的抗肿瘤药效学研究：用小鼠肝癌H22进行"长动"合并放疗和化疗的增效作用研究；用MTT法进行"长动"对肝癌QGY、肠癌LOVO、肺癌A549、乳腺癌MCF-7、小鼠白血病P388等10株人体和动物肿瘤细胞的体外细胞毒性作用研究；用淋巴细胞转化试验、小鼠NK细胞活性试验、小鼠胸腺细胞增殖法分别测定"长动"对荷Lewis肺癌小鼠的脾淋巴细胞增殖的影响、自然杀伤细胞活性的影响和对小鼠产生白介素-2(IL-2)的影响；用流式细胞仪PI单染色法进行"长动"对人体肝癌QGY细胞的体外诱导凋亡作用和对肿瘤细胞周期的影响的研究。

The performance and mechanism of corrosion inhibitions of POCA were studied bymethods such as weight-loss, electrochemistry, EDS, XPS and quantum chemistry. It isfound that POCA is cathodic corrosion inhibitor, having synergistic effect with HEDP andZn~(2+). The P and O atoms of phosphono have important electron density contribution toHOMO orbital and the electron gross orbital population is bigger than 1, so it is easy toform absorbing location between phosphono and metal resulting in good corrosioninhibition on mild steel.

通过利用失重法、电化学方法、扫描电镜、X光电子能谱、X-射线能谱和量子化学方法研究膦酰基羧酸的缓蚀性能及其机理，发现POCA是一种阴极型缓蚀剂，与HEDP、Zn~(2+)具有优良的协同增效作用；POCA分子中的膦酰基基团的P原子和O原子对HOMO轨道电荷密度贡献较大，且其轨道电子布居数均大于1，因此比较容易通过膦基与金属形成吸附位而对碳钢具有良好的缓蚀作用；对铜合金具有一定的腐蚀作用，但腐蚀作用比HEDP等有机膦药剂要小得多，同时与BTA具有优良的相容性，添加1mg／L的BTA则可以有效地防止铜合金的腐蚀。

Objective The toxicity and synergism of several commonly used insecticides mixed with Piperonyl Butoxide against the larvae of Culex pipiens pallens collected from fields of three regions in Shandong province were determined for controlling vector mosquitoes by scientifically rational use of insecticides as well as delaying and overcome the occurrence and development of resis-tance.

目的 了解常用杀虫剂与增效剂氧化胡椒基丁醚（S 1 ）混用对山东省三个不同地区现场淡色库蚊的毒力及增效作用。

The results from bioassay showed that both the capsules of PuGV－Ps and the partially purified synergistic factor enhanced infection of Pseudaletia separata nuclear polyhedrosis virus in the larvae of armyworm significantly.

生物测定的结果表明，粘虫颗粒体病毒PuGV－Ps及其增效因子对粘虫核型多角体病毒PsNPV均有明显的增效作用。

The results of field trial of insecticides showed that SV1 had synergistic effect to Tetranychus urticae Koch on apples and cowpea.

田间药效试验结果表明：增效剂SV1和S2 与氧乐果、甲氰菊酯、螨死净混用，对苹果和豇豆上的二点螨均有增效作用。

In order to reveal the the characteristics of the synergistic and antagonistic mixtures on fungicide, that article through the tests of mycelial growth rate,going on the determination of the synergies of the partners of Thiram and Tebuconazole to Fusarium graminearum.

为了揭示药剂组合产生增效与拮抗的特性，本文通过菌丝生长速率法，进行了福美双与戊唑醇药剂组合对小麦赤霉病菌的协同增效作用测定。

Pbo significantly synergizes fenvalerate、cypermethrin and methomyl against Xihua field resistant strain ofHelicoverpe armigera , TPP can somewhat synergize pyrethroids also.

对西华田间棉铃虫抗性种群，Pbo能显著地增加氰戊菊酯、氯氰菊酯、灭多威的毒力，大幅度地降低其致死中量，TPP对两种拟除虫菊酯杀虫剂也表现一定的增效作用；对甲基对硫磷、甲胺磷，无论是Pbo还是TPP其增效作用均十分有限。

The insectide mixtures of pyrethroids or organochloride with organophosphate or carbamate may have better efficacy against DDVP-resistant mosquitoes,and the mixed use of the insecticide with synergists may also provide better efficacy.

当淡色库蚊对DDVP产生抗药性后，氯氰菊酯或三氯杀虫酯与DDVP或残杀威混用均能取得较好的防制效果，DDVP与增效剂复配亦有增效作用。

Enlarge effection of the mixture of. PB and Beta-cypermethrin accord with equation y =-0.0156x2 + O.I623x + 1.2098(r = 0.8862). Other several proportion of insecticide with PB is 5:1, Tetramethrin's enlarge effection is 2.51 times The Permethrin is 1.40 times, D-trans allethrin is 0.50 times, D-prallethein is 1.67 times ,80% DDV milk is 1.38 times.

PB对高效氯氰菊酯的增效作用符合方程y=-0.0156x~2+0.1623x+1.2098(r=0.8862)，以PB和其它几种杀虫剂的比例为5：1时，对敏感家蝇种群成虫的毒力增效倍数为胺菊酯2.51倍、氯菊酯1.40倍、右旋反式丙烯菊酯0.50倍、右旋丙炔菊酯1.67倍、80％DDV乳油1.38倍，各杀虫剂与PB混配均表现为相加作用。

This one mode pays close attention to network credence foundation of the businessman very much.

这一模式非常关注商人的网络信用基础。

Cell morphology of bacterial ghost of Pasteurella multocida was observed by scanning electron microscopy and inactivation ratio was estimated by CFU analysi.

扫描电镜观察多杀性巴氏杆菌细菌幽灵和菌落形成单位评价遗传灭活率。