增强剂

Results are as followed:1 Exposure of HELF cells to BP caused c-Jun activation,and increased the activity of MAPK,PI-3K,p53 and cyclin D1 pathway.2 BP-induced c-Jun activation was inhibited by dominant negative mutants of extracellular signal-regulated protein kinase or c-Jun NH_2-terminal kinase,but not by p38,impling that JNK and ERK pathways medicate c-Jun activation induced by BP.3 Overexpression of dominant-negative mutants PI-3K and Akt potently blocked phosphorylations of c-Jun and ERK,but not JNK in response to BP,suggesting that PI-3K/Akt pathway positively regulates BP-induced c-Jun activation through ERK.4 Inhibition of p53 by its chemical or molecular inhibitor markedly increased the phosphorylation levels of c-Jun,Akt and ERK upon BP stimulation,indicating that p53 negatively medicates BP-induced c-Jun activation through PI-3K/Akt/ERK pathway.5 The cell lines expressed TAM67 exhibits no significant affecting normal cell growth properties.6 TAM67 was able to significantly block G_1-S transition and subsequent cell proliferation,suggesting that c-Jun is essential for cell cycle alternations elicited by BP.7 Overexpression of TAM67 impaired BP-induced cyclin D1 activation,decreasing expression of E2F1 and pRb,indicating that c-Jun participates in the modulation of BP-induced activation of cyclin D1/pRb/E2F1 pathway.8 Stably expression of TAM67 led to the increases in the expression levels of p53 and p21,elevating phosphorylation level of p53,clearly indicating that c-Jun regulates p53/p21 pathway activation induced by BRCollectively,PI3K/Akt/ERK pathway mediated BP-induced c-Jun activation through p53-dependent mechanism.

结果显示：1BP刺激细胞可促进c-Jun活化，并伴随着MAPK、PI-3K、p53和cyclinD1通路各组成成分的活性增强。2利用MAPK通路的显性失活突变体分别阻断细胞外信号调节激酶和c-Jun氨基末端激酶活性，均可明显抑制BP诱导的c-Jun活化，但阻断p38活性对BP引起的c-Jun活化无明显影响，提示JNK和ERK通路参与调控BP诱导的c-Jun活化。3过表达PI-3K和Akt的显性失活突变体也可显著抑制BP诱导的c-Jun活化，并降低磷酸化ERK的表达水平，但对磷酸化JNK的表达水平无明显影响，说明PI-3K/Akt通路通过ERK正性调控了BP诱导的c-Jun活化。4p53的化学/分子抑制剂能使BP作用的细胞内c-Jun活性明显增加，并同时诱导Akt和ERK的磷酸化水平的升高，表明p53可通过PI-3K/Akt/ERK通路对BP诱导的c-Jun活化进行负性调控。5随后观察转染细胞的生长情况，发现TAM67对细胞正常生长和形态无明显影响。6稳定表达TAM67可有效抑制BP诱导的S期细胞数的增加，提示c-Jun在BP致细胞周期改变的过程中发挥了重要作用。7TAM67过表达能够抑制BP诱导的cyclin D1活化，降低磷酸化Rb以及E2F1蛋白表达水平，表明c-Jun参与调控BP诱导的cyclin D1/Rb/E2F1通路的活化。8过表达TAM67可使BP刺激的细胞中p53、p21总蛋白以及p53磷酸化的表达水平明显升高，可见c-Jun也参与调控BP诱导的p53/p21通路活化。

MRI Leptomeninges Contrast enhancement Metastases

磁共振成像；对比剂增强；脑膜；转移

Hase separation was taken place during process.PHBHQ could form mesomorphic domain and played a role in inducing and enhaneing silver crack and shearing region,therefore absorbed large energy and made the impact strength of epoxy resin increase greatly.

HBHQ/CYD-128/固化剂体系是部分相容体系，在成型过程中发生相分离，PHBHQ能形成介晶域，起增强和诱发银纹和剪切带的作用，从而吸收大量的能量，使环氧的韧性得以大幅度地提高。

The oral liquid is superior to available medicine and method of treating Duchenne muscular dystrophy in that it has the effects of preventing muscle fiber necrosis, promoting muscle fiber regeneration, strengthening myodynamia, and lowering CPK, LDH and other biochemical indexes.

解决了现有治疗DMD疾病的药物或方法如免疫抑制剂、皮质类固醇类激素、硫唑嘌呤及和环孢霉素A等的缺陷。具有防止肌纤维坏死，促进肌纤维再生，肌力增强，CPK、LDH等生化指标下降，病症明显改善的效果。而姜黄素原来主要用于治疗肿瘤、溃疡、肝炎，以及降血脂、忧郁症等。

The invention is made though synthesizing inorganic reinforced components with optimized surfactant and antistatic agent and has the advantages of toxin-free, hazard-free, nonirritant, chlorine-free, flame retardant and non-corrosive.

本发明含聚羧酸系的复合活化水泥增强助磨剂是通过高效磁化活化和复合技术合成的中性高效复合水泥添加剂。

The mechanical properties of coal filled polymer composites The mechanical properties of coal/PP composites were investigated, and the effects of coal rank, particle size, surface modification of coupling and alkylation were discussed. The results show that the anthracite and bituminous coal all can be used as filler of plastic after pretreatment of part devolatilization and surface modification; The modulus of composites increase with the content of coal filler; The coupling agent is of no effect for reinforcing the coal/PP composites, except that there are new oxygenous function group forming on the surface in the process of pulverizing; The F-C alkylation reinforce coal (under 10μm)/PP composites obviously.

4煤填充高分子复合材料力学性能超细煤粉填充聚丙烯复合材料力学性能的研究结果表明，烟煤和无烟煤经过脱除部分挥发分的预处理后，都可用于与塑料共混制备复合材料；偶联剂改性对低变质程度烟煤/聚丙烯复合材料的力学性能基本不起改善作用，而对于经气流超细粉碎后的小粒径高变质程度烟煤及无烟煤则有一定的增强作用；烷基化改性在煤表面接枝了烷基，使平均粒径小于10μm的煤/聚丙烯复合材料拉伸屈服强度普遍提高，煤填充高分子复合材料可在较高含煤量情况下维持良好的力学性能。

In addition,applying nitrification inhibitors could increase vitamin C and soluble sugar contents in pakchoi,and promote N and P uptakes by pakchoi.

另外，3种硝化抑制剂还能显著提高小白菜的维生素C和可溶性糖含量，增强对N，P养分的吸收。

Sensory impairment and urinary dysfunction also had developed, and paraparesis persisted after the hypokalemia was corrected during hospitalization. An optokinetic nystagmus test showed bilateral sick waves and at the same time a cerebrospinal fluid analysis was normal. A blood examination disclosed borderline anti-nuclear antibodies and an elevated serum IgG level. Her cervical spinal cord showed mild swelling and contrast-enhancement when examined by magnetic resonance imaging. Neither a brain stem nor an optic nerve's lesion was found. Based on the above, acute transverse myelitis was diagnosed. All the symptoms present in the patient relieved gradually after 5-days of pulsed intravenous methylprednisolone therapy.

一50岁女性，因为眩晕、前额头痛、视力模糊、恶心、呕吐及两侧下肢无力而求诊，於低血钾矫正后，两侧下肢无力依然持续，并发生胸部以下感觉缺损及排尿困难等现象，视运动性眼振检查显示两侧波形障碍，脑脊液检查正常，血液学检查显示抗核酸抗体及血清IgG指数偏高，显影剂增强磁振造影显示颈段脊髓肿大且略为显影，并无脑干或视神经的病灶，诊断为急性横断性脊髓炎，给予静脉注射类固醇后症状逐渐缓解。

There are four kind of isoforms of endothelin in human and other mammals named ET-1, ET-2, ET-3 and ET-β, which are slightly different in construction and pharmacological effect. In human beings, ET-1 is the dominative subtypes. ET-1 remains in blood at a low level about 5ng per liter on physical state. It is synthesized, stored, released and metabolized locally. The half-life of ET-1 is about 1 hour. ET-1 is the most potent vasoconstrictive factor till now, and it is more functional in vein than in artery. In vascular bed, there are two kind of ET receptors. Type A mainly located in smooth muscle cells, whereas type B in endothelial cells. The latter can stimulate intimal hyperplasia via a parasecretion way and activate some oncogenes such as c-fos and c-myc and then enhance their expression. These alterations result in constriction of blood vessels, thus the SMC steps into proliferate state from silent state.

人及哺乳动物体内有四种结构及药理学性质略有差异的异物体，分别为ET-1、ET-2、ET-3、ET-β，而在人主要是ET-1，在生理条件下，ET-1在血浆中含量较低，约为5ng〓，故ET-1不是一个循环激素，而是局部合成释放，局部起作用的活性物质，半衰期约1小时，ET-1是目前已知的最强的血管收缩剂，对静脉的作用比动脉强，在血管床，ET受体有A、B两型，A型主要分布在平滑肌细胞，B型主要分布在内皮细胞，它可以通过旁分泌途径刺激内膜增生，具有有丝分裂原效应，可以激活某些癌基因如C-fos、C-myc使其表达增强引起血管收缩，使静止期SMC进入增殖期，还可以通过信号传导途径，与bFGF、GTF-β、PDGF等生长因子协同作用，起共有丝分裂原作用。

In order to develop a liquid oxidation desulfurization technique, the characteristic of desulfurization of sodium Phosphomolybdate absorbent system was investigated by the method of dynamic tail-gas H,S concentration detection and the regeneration behavior of the same system was investigated by the method of redox poteatial detection.

以液相氧化脱硫工艺开发为目的，采用尾气H2S浓度动态监测法研究了磷钼杂多化合物脱硫体系的脱硫特性；采用氧化还原电位监测法研究了该体系的再生规律结果表明，磷钼酸钠体系的脱硫性能随温度升高而有所降低，随进气H2S浓度的提高而相应降低，随吸收剂浓度的提高而显著增强。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。