增序列

Results Mobiligy shifts of SSCP in exon 5 of presenilin-1 was detected in 4 cases with Alzheimer,s disease. Two missense mutation were found in the patients by DNA sequence analyse, one mutation was Leu 130 Met and the other was Vall 57 Leu.Another 11 patients showed one single strend shifted rapidly. But none mobility shifts of SSCP were found in patients with vascular dementia and normal controls. Conclusions It is shown that mutations in exon 5 of presenilin-1 also exist in the patients with sporadic Alzhemer?

结果 发现4名SAD患者的PCR产物SSCP分析发生泳动异常，DNA序列分析发现：这4名SAD患者的130号密码子发生了CTG→ATG错义突变(388位点发生C→A突变)，使编码的氨基酸由亮氨酸变为蛋氨酸(Leu 130 Met)；157号密码子发生了GTG→CTG错义突变(469位点发生G→C突变)，使编码的氨基酸由缬氨酸变为亮氨酸(Val 157 Leu)，另有11名患者SSCP表现为一条单链增快，其性质待定。

In addition to promoter regions, transcription of most eukaryotic genes is regulated by other dna sequences called enhancers.

除了启动子区域外，大多数真核基因的转录还受到另一段被称为增强子的dna序列的调控。

We started with two most annotated splicing elements, exonic splcing enhancers and silencers.

我们从影响剪切的两类序列元件入手，外显子增强子(exonic splicing enhancer， ESE)和减弱子(exonic splicing silencer， ESS)。

Results Group C had the symptoms such as reduced activity, acceded, indulge in lying and weight loss after 3 weeks of immune injection, 14 out of 16 SD rats in Group B had the same symptoms as Group C after 4～5 weeks of immune injection, the serum enzymes in model groups increased significantly compared with those of the control group, model group C was much higher than model group B; the duration shorted, amplitude decreased, multiphase wave increased in electromyogram of model groups; MRI examination revealed samples from model group B and C had one positive case each, which presented T1MI isodensity or hypodensity signal, T2MI and STIR serial hyperdensity signal, revealing muscle inflammation; all rats'skeletal muscle from model group C and 11 out of model group B had pathological changes, which exhibited striated muscle focal fiber degeneration, necrotized and inflammatory cell infiltration, interstitial vessel wall thickening, random cardiac muscle samples had 3 positive changes, which had similar changes to skeletal muscle, there was 1 positive change from lung sample.

结果：模型C组于免疫注射第3周左右开始出现活动减少，倦怠嗜卧，食欲体重下降等表现，模型B组有14只SD大鼠于免疫注射第4～5周出现上述症状，较C组为轻；模型组肌酶谱中，肌酸激酶、乳酸脱氢酶、谷草转氨酶与对照组比较明显升高，模型C组较模型B组升高更显著；模型组肌电图时限缩短，波幅降低，多相波增多；磁共振检查模型B组和C组选送标本中各有一例有阳性改变，表现为T1MI等或稍低信号，T2MI及STIR序列为高信号，提示肌肉炎症水肿改变；模型B组有11只，模型C组全部大鼠骨骼肌出现病理改变，表现为横纹肌局灶性分布的肌纤维变性炎细胞浸润，间质小血管壁增厚、扩张，随机选送的心肌标本中有3例有阳性改变，表现与骨骼肌相仿，选送的肺标本中有1例有阳性改变，表现为蛋白渗出，炎症细胞浸润和小血管改变。

By incrementing the iterator, each element in the sequence can be processed.

通过这个对迭代器进行自增的过程，即可处理该序列中所有的元素。

On the other hand, the more important thing is because the urban housing is a kind of heterogeneity products.

另一方面，更重要的是由于城市住房是一种异质性产品。

Climate histogram is the fall that collects place measure calm value, cent serves as cross axle for a few equal interval, the area that the frequency that the value appears according to place is accumulated and becomes will be determined inside each interval, discharge the graph that rise with post, also be called histogram.

气候直方图是将所收集的降水量测定值，分为几个相等的区间作为横轴，并将各区间内所测定值依所出现的次数累积而成的面积，用柱子排起来的图形，也叫做柱状图。