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METHODS: We searched for abnormalities of the proapoptotic Bcl-x deamidation pathway in primary cells from patients with chronic myeloid leukemia or polycythemia vera, myeloproliferative disorders associated with the BCR-ABL fusion kinase and the Janus tyrosine kinase 2 (JAK2) V617F mutation, respectively.

我们分别对来自慢性粒细胞白血病或真性红细胞增多症、骨髓增生性疾病相关的BCR-ABL融合蛋白激酶及Janus酪氨酸激酶2 (JAK2) V617F突变体患者原代细胞凋亡前Bcl-x脱酰胺途径的异常情况进行研究。

RESULTS Duodenal ulcer was the first cause of upper gastrointestinal hemorrhage. Gastric ulcer, cirrhosis, Mallory-Weiss syndrome or acute gastric mucous lesion was the second cause of the illness alternatively. The rate of endoscopy and emergent endoscopy has been going up year after year and got up to 80% in 1998. Bleeding and active hemorrhage, respectively were found in 24.3% and 14.9% of the patients underwent endoscopy before medication. Endoscopic hemostasis was performed in 108 patients by spraying hemostatics and a good response was achieved subsequently. Hemostatics were mainly cimetidine and yunnan baiyao before 1994. Reptilase, pPI, famotidine and ranitidine were used increasingly while cimetidine and yunnan baiyao were used decreasingly. Octreotide was used in patients with cirrhosis commonly. The length of hospital stay and the period from admission to bleeding cease tended to be shorter year by year, but the reduction rate was small. The uses of ranitidine, famotidine, pPI, reptilase, octreotide, early endoscopy and endoscopic therapy may play a role in improving the therapeutic effect of hemostasis, reducing the hospitalization and the mortality.

结果 十二指肠球部溃疡是历年上消化道出血的首要原因,胃溃疡、肝硬变、Mallory -Weiss综合征、急性胃粘膜病变则交替成为第2位出血原因;内镜诊断率和急诊内镜率逐年提高,1998年达到80%,内镜下见出血者占内镜检查的24.3%,而见到活动性出血者仅占内镜检查者的14.9%;内镜下止血108例次,成功率100%;1994年前治疗药物主要为云南白药和甲氰咪胍,之后,随着立止血、质子泵抑制剂、法莫替丁、雷尼替丁等药物使用的逐渐增多,前二者的使用逐渐减少,善得定多用于肝硬变出血;住院天数和止血天数呈逐年下降的趋势,但幅度微小;雷尼替丁、法莫替丁、PPI、立止血、善得定的使用以及及时的内镜检查和内镜下治疗在提高止血效果、缩短住院天数、降低死亡率方面可能起到了一定作用。

Analytic branch amount and branch angle are right produce can influence discovery: Mi Qian is planted increase of number of branch of? of You of that a pavilion or house on a terrace of joyous ǖ of Сざ sew, produce can reduce somewhat, think branch well should not seek overmuch branch amount, with 2~3 branch is advisable; branch angle increases, the yield of much branch well also can increase, but addition extent decrescent.

分析分支数目和分支角度对产能的影响发现:在总分支长度一定的情况下,分支数目增多,产能略有降低,认为分支井不应追求过多的分支数目,以2~3个分支为宜;分支角度增大,多分支井的产能也增大,但增加的幅度变小。

On the basis of census of all individuals of the populations at different plots, the structure and dynamics of the populations were described. The result showed that P. tabulaeformisf.shekannesis were growing populations, and the distributions of the structure were reverse J. The density decreased with the increasing of Size-class structure. The populations developed the characteristic of increasing in the early stage and stabilizing in the late. The survive curve of Pinus tabulaeformisf.shekannesis were between DeeveyⅡand DeeveyⅢ. The analysis of time sequence showed that most of the inividuals would be adult after 20 years.

结果表明:柴松种群结构呈反J分布型,种群处于增长阶段;种群的密度随径级的增加而降低,种群密度与径级呈现出明显的负相关;四个函数估计值说明柴松种群具有前期增长、后期稳定的特点,其存活曲线介于DeeveyⅡ型和DeeveyⅢ型之间;随时间推移,种群中树和大树数量逐渐增多,种群在20年后开始大量进入成熟阶段。

The results showed that:(1) the upper elevation limit of the closed forests was found to be 4320 m; the timberline elevations was 4520 m on the sunny side with a gradualtype;(2) for the diameter class structure of the populations, most individuals were from Ⅰto Ⅳ, the number decreased sharply with the increase of diameter class, the survival curves were between Deevey type Ⅰ and Ⅱ, with an approximately stalbe trend; the variation trends of mortality rate q(subscript x and hazard ratek(subscript x were similar;(3)the analysis by time sequence model demonstrated that the individuals of the older age class would be increasing, indicating that S.

死亡率q(下标 x和消失率k(下标 x变化基本趋势一致;都在Ⅲ龄级出现低谷;以后死亡率和消失率曲线均随龄级增加而上升;时间序列分析表明;未来种群发展老龄个体逐渐增多

Then when they were drunk, hatred and murder increased among them; one man used violence against another to teach him evil taking his children and defiling them before him.

8他们在喝酒后,仇恨与谋杀在他们间增多了,一个人用暴力教给了别人罪恶,在他面前使他的孩子们玷污。

However, there were a great number of inflammatory cells, epithelial proliferation, partial breakage and defluvium of the airway epithelium in the bronchus, below the vessel mucous membrane and around lung tissues in the model control group.

正常对照组小鼠气道无明显炎症改变;模型对照组小鼠支气管、血管粘膜下和周围肺组织有明显炎症细胞浸润、气道上皮增生、气道黏液增多、气道上皮部分断裂脱落;细胞移植组小鼠气道炎症明显减轻。

FCM analysis showed that the apoptotic rate of MDA-MB-231 cells and intracellular Ca(superscript 2+) concentration increased gradually with the increase of deguelin concentration. RT-PCR and Western blotting analysis showed that the expression of Bcl-2 mRNA and protein was clown-regulated and that of Sax was op-regulated after deguelin treatment.

流式细胞术检测显示细胞凋亡率和细胞内钙离于浓度随鱼藤素浓度的增加而增多;RT-PCR和蛋白印迹检测结果发现鱼藤素能使Bcl-2 mRNA和蛋白表达减少,而Bax表达增加。

Results: After 24h exposure to rhBMP-2, the expression of PCNA in HFCL cells decreased 0.65 fold by densimetric scanning. Observed after staining with the Wright-Gimsa, the numbers of cells with mitosis imaging decreased, but the morphologic change of cells did not happen. The HFCL cell numbers in S phsae decreased while in G1 phase increased, the cell cycle was arrested at G1 phase HFCL cells did not differentiate to myelocytic or mononucleate cells.

结果:经过rhBMP-2作用24h后,HFCL细胞PCNA表达下降,经灰度扫描下降幅度为0.65倍;瑞氏-吉姆萨染色后发现细胞核分裂像减少,分裂指数下降,但细胞形态没有变化;HFCL细胞S期中的细胞数量减少,G1期数量增多,出现G1期阻滞;rhBMP-2作用没有使HFCL细胞向髓系或单核方向分化的趋势。

Results: In sclerotic dentin (15 s), the hybrid layer was visible, with minimal resin tags in the dentinal tubules and, when presented, they were shorter.

结果:15s组粘接界面可见混合层,牙本质小管内的树脂突短小。30s组树脂突增多并出现管周牙本质的混合层。

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The absorption and distribution of chromium were studied in ryeusing nutrient culture technique and pot experiment.

采用不同浓度K2CrO4(0,0.4,0.8和1.2 mmol/L)的Hoagland营养液处理黑麦幼苗,测定铬在黑麦体内的亚细胞分布、铬化学形态及不同部位的积累。

By analyzing theory foundation of mathematical morphology in the digital image processing, researching morphology arithmetic of the binary Image, discussing two basic forms for the least structure element: dilation and erosion.

通过分析数学形态学在图像中的理论基础,研究二值图像的形态分析算法,探讨最小结构元素的两种基本形态:膨胀和腐蚀;分析了数学形态学复杂算法的基本原理,把数学形态学的部分并行处理理念引入到家实际应用中。

Have a good policy environment, real estate, secondary and tertiary markets can develop more rapidly and improved.

有一个良好的政策环境,房地产,二级和三级市场的发展更加迅速改善。