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Matrix metalloproteinase 9 (MMP9) is one of the representative substances that can degrade basement membrane and extracellular matrix.

基质金属蛋白酶9(matrix metalloproteinase 9,MMP9)是降解细胞基底膜,包括细胞外基质的代表性物质。

Matrix metalloproteinases, which degrade extracellular matrix and basement membrane, plays an important role in many inflammatory diseases.

基质金属蛋白酶(matrix metalloproteinases,简称MMPs)是可以分解细胞外基质和基底膜的蛋白质水解酶,在许多疾病中扮演重要的角色。

The matrix metal of DF-5 bearing and the lubricating film formed by the solid lubricant can bear higher load under the condition of high temperature.

DF-5铜基镶嵌自润滑轴承的铜合金基体、固体润滑剂形成的润滑膜在较高的温度下可承受较高的载荷。

Through the opening design of the black matrix at the overlapping region between the public electrode on the black matrix on the color film substrate and the data line leads or/and grid line leads on the array substrate, the invention avoids strong contacts between Au-ball lead and the protective layer on the data line leads or/and grid line leads so as to prevent electrostatic breakdown and improve product yield.

本发明通过在彩膜基板的黑矩阵上的公共电极与阵列基板上的数据线引线或/和栅线引线交叠区域的黑矩阵采用开口设计,避免Au-ball与数据线引线或/和栅线引线上面的保护层形成强力接触,防止了静电击穿发生,提高了产品的良率。

Construct PLXRN-IL-1Ra and PLXRN-IL-10 vector, lapine synoviocytes were first transduced in culture by retroviral infection. The genetically modified synovial cells were then transplanted by intra-articular injection into the knee joints, assay of joint lavages confirmed that the gene expression was not lost after 14 days of transfer. Knees receiving the hIL-1Ra had significantly reduced cartilage breakdown. Delivery of the hIL-10 was less effective, When both genes were used together, there was a greater inhibition of cartilage breakdown and a considerable reduction of cartilage matrix degradation.

构建PLXRN-IL-1Ra、PLXRN-IL-10逆转录病毒载体,体外感染同种异体原代滑膜细胞,接着将转染了外源基因的滑膜细胞行关节腔注射入创伤性骨关节炎兔膝关节,通过对关节滑液的ELISA分析证明外源基因的表达在基因转移后14天还很稳定,只接受hIL-1Ra基因治疗的膝关节软骨损坏明显减轻,接受hIL-10基因治疗的膝关节治疗也有一定效果,当两种基因同时导入时,有非常明显的抑制软骨破坏和软骨基质降解的作用。

Two kinds of poly(3-hexylthiophene) films with the same chemical compositions were subjected to a charge transport study in order to examine possible influences of film structures on mobilities of charge carriers.

对两种具有相同化学结构的聚(3-己基)噻吩膜进行了电荷传导研究以检验膜的结构对载流子迁移率的影响。

Umbels compound; bracts few or absent; rays few to many; bracteoles few to many, lanceolate or linear, bases often connate, scarious or scarious-margined; umbellules few- to many-flowered; pedicels short or long, occasionally subsessile.

复伞状花序苞片很少或无;伞辐少数到多数;小苞片少数到多数,披针形或者线形,基部通常合生,干膜质或者干膜质边缘;小伞形花序有花少数至多花;花梗短或者长,偶尔近无柄。

A Dense scale on the2O3(Cr/Y=4/1) coated specimen;2O3(Al/Y=3.6/1) coated specimen; Oxide nodules formed at the corner on the specimen coated with2O3(Cr/Y=2/1) deposited for 15 s; Locally spalled scale on the same specimen as in; The trace of cracks in the deposited oxide film on the scale formed on the specimen coated with2O3 (Cr/Y=2/1) deposited for 60 s; Showing the similar trace on the same specimen as in b

沉积复合OTFC试样的氧化层形貌有如下特征:(1)氧化层绝大部分致密、完整、与基体附着良好,晶粒细小(图7a,7b);(2)在短时间(15s)沉积2O3 OTFC试样的局部表面出现了不均匀氧化(图7c,7d),但只是在沉积Cr/Y=4/1膜试样的局部表面产生了类似无涂层Fe25Cr上剥落的厚膜(图7d);(3)沉积2O3(Cr/Y=2/1) 60s(图7e)与15s(图7c)的结果不同,前者整个试样表面氧化产物颗粒细小,无粗大氧化物颗粒形成;(4)沉积2O3(Cr/Y=2/1) 60s和2O3(Al/Y=3.6/1)薄膜的试样由于氧化增重非常少,氧化层很薄,刻印着涂层中局部出现的裂纹(图7e,7f),这种印迹的保留可能反映着传质机制的改变,即新氧化物由在外表面形成转变为在外表面以下形成。

It could obtain the best performance of flux, retainment of tea composition and flavor under such operate condition.

经过热加工的茶汤在蓊游离胺基酸、还原糖、catechin、EGCg、ECG比膜过滤还高,但在清除DPPH和螯合亚铁离子的表现上,却比膜过滤还要佳。

After amplying a 2.2kb fragment form the PPV-SC1 RF-DNA,we clone the fragment into pMD 18-T,named pTNSl.The whole sequence which is 1989 bp long was determined by sequencing, including the complete ORF of PPV-SC1 NS1 which encoding 662 amino acids.Alignment of pairs of sequence indicates that there are 98% and 99% similary with other porcine parvovirus strains Kresse and NADL-2, respectively. Multiple sequence alignment discloses that there are a few difference between ppv-scl nsl gene and other ppv nsl gene: A-G at 39nt,T-C at 153nt,A-G at 175nt, A-C at 1117nt, A-C at 1535nt .Alternative codon in ppv-scl nsl have distinctly different frequentfy by codonbias analysis at EMBOSS(http://genopole.toulouse.inra.fr/bioinfo/emboss). Thereis not distinct hydrophobicity and transmenbrane helices in ppv-scl nsl protein. Struction domain anslysis of PPV-SC1 NS1 protein indicate that there are a ATP/GTP-binding site motif A at 398-405,16 Protein kinase C phosphorylation site,21 Casein kinase II phosphorylation site,and 3 cAMP/cGMP-dependent protein kinase phosphorylation site.At the same time ,there is a same motif between ppv-scl nsl and Poxvirus D5 protein-like which may share in the same fuction which is necessary during virion duplication.

将PPV-SC1 NS1序列与其他PPV NS1基因进行多序列比对,结果显示,PPV-SC1 NS1与其他的PPV NS1的同源性较高,仅存在个别的差异,分别是第39位A→G,第153位T→C,第175位A→G,第1117位A→C,第1535位A→C;同源搜索比较表明,PPV-SC1与PPV NS1同源性可达98%、99%,与其他的细小病毒NS1基因也存在很大的保守性;密码子偏向性分析结果表明PPV-SC1 NS1基因在同一氨基酸的不同密码子的选择上存在一定的偏向性;PPV-SC1 NS1蛋白总体上说具有亲水性不存在明显的疏水性区段,用swiss TMPRED软件预测PPV-SC1 NS1的跨膜区,返回的结果并没有得到有显著意义的跨膜区的存在;根据基于motif数据库的结构域预测,PPV-SC1 NS1的第393-415位氨基酸残基存在潜在的ATP/GTP结合位点,该蛋白还存在16个蛋白激酶C磷酸化位点,21个酪蛋白激酶2磷酸化位点,3个cAMP-/cGMP依赖蛋白激酶磷酸化位点,PPV-SC1 NS1蛋白与POX_D5(痘病毒D5蛋白)具有一致的保守结构域,推测NS1可能与POX_D5有类似的功能。

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With Death guitarist Schuldiner adopting vocal duties, the band made a major impact on the scene.

随着死亡的吉他手Schuldiner接受主唱的职务,乐队在现实中树立了重要的影响。

But he could still end up breakfasting on Swiss-government issue muesli because all six are accused of nicking around 45 million pounds they should have paid to FIFA.

不过他最后仍有可能沦为瑞士政府&议事餐桌&上的一道早餐,因为这所有六个人都被指控把本应支付给国际足联的大约4500万英镑骗了个精光。

Closes the eye, the deep breathing, all no longer are the dreams as if......

关闭眼睛,深呼吸,一切不再是梦想,犹如。。。。。。