基因型

In addition, DNA methylation profiles segregated patients with CEBPA aberrations from other subtypes of leukemia, defined four epigenetically distinct forms of AML with NPM1 mutations, and showed that established AML1-ETO, CBFb-MYH11, and PML-RARA leukemia entities are associated with specific methylation profiles.

此外，根据DNA甲基化的不同可将CEBPA基因畸变与其他亚型的白血病区分开来，并定义出四个不同表型的伴NPM1基因突变的急性髓系白血病，并且表明AML1-ETO， CBFb-MYH11，和 PML-RARA 三种白血病类型与特定的甲基化有关。

As the changes reflect some genes expressed herein, identification and characterization of the differentially expressed genes will be helpful to understanding the molecular mechanism of erythroid terminal differentiation.

这些表型的变化反映了一系列内在基因的开启和关闭。显然这些基因的鉴定与克隆对阐明红系细胞终末分化的机制有重要意义。

Key words］desmoid-type fibromatosis;adenomatous polyposis coli gene;β-catenin gene;denaturing high performance liquid chromatography

关键词］韧带样型纤维瘤病；APC基因；β-catenin基因；变性高效液相色谱分析

To investigate the disorder of Wnt signal transduction pathway in tumorigenesis, we studied the adenomatous polyposis coli gene and β-catenin gene mutations in desmoid-type fibromatosis.

本研究分析了韧带样型纤维瘤病中APC和β-catenin基因突变，探讨Wnt通路中APC/β-catenin基因异常在肿瘤发生中的作用。

The thesis focuses on gene diagnosis of diseases, and six new homogenous fluorogenic probes are developed.

本文致力于疾病的基因诊断研究，开发了六种新型的均相荧光基因检测探针，并以病人血清中的乙型肝炎病毒为检测对象，对上述六种探针的检测效果进行。。。

The thesis focuses on gene diagnosis of diseases, and six new homogenous fluorogenic probes are developed. Using hepatitis B virus in human sera as targets, the detection effects of these probes are discussed.

本文致力于疾病的基因诊断研究，开发了六种新型的均相荧光基因检测探针，并以病人血清中的乙型肝炎病毒为检测对象，对上述六种探针的检测效果进行了评估。

The strongest evidence for linkage in 147 families with late-onset PD was on chromosome 17 near the tau gene -- previously shown to be involved in other neurodegenerative diseases including frontotemporal dementia with parkinsonism and progressive supranuclear palsy.

147个患有迟发型帕金森氏症的家庭在遗传研究中被发现，该病与17号染色体上的tau基因有关联。以前tau基因被认为与其它的神经变性疾病有关，如伴有震颤麻痹的额颞型痴呆以及进行性核上性麻痹有关。

The PCR based assay was tested on 19 strains isolated in throats from patients with guttate psoriasis. The results demonstrated that 6 strains were positive in 15 streptococus strains among which there were 3 streptococus pyogenes, 1.S.agalactiae, 1 S. eguisimilis and 1 S. uberis, and 4 non- streptococus strains were negative. Emm6 was found not only in suppurative hemolytic streptococus, but also in S.uberis.

应用聚合酶链式反应方法对点滴型银屑病患者咽部培养出的19株细菌中的M6蛋白基因进行检测，结果，15株链球菌中6株为阳性，其中化脓链球菌3株，无乳链球菌、似马链球菌和乳房链球菌各1株，4株非链球菌均为阴性。M6蛋白基因不仅存在化脓性溶血链球菌中，在其它链球菌如乳房链球菌中也存在。

In the research, one kind of guzmania species named ostara was employed to be as material, and the full-length cDNA plasmid library of floral organ was constructed successfully by using SMART technology. The library had 3×10^6 original titer and more than 1 kb insert fragments. After 5'EST sequencing from 2004 positive clone chosen at random and clustering analyse, 1 758 high-quality sequences and 1 365 unigenes including 175 contigs and 1 195 singlets were obtained. These unigenes had 1 283 valid ORFs. COG analysis showed that those proteins coded by EST sequences were divided into 22 classes. Through blast analysis, full length or part cDNA of some genes controlling flower color, development of floral organs, florescence regulation and other breeding value genes were obtained.

本研究以擎天凤梨属品种Ostara为材料，采用SMART技术成功构建了擎天凤梨花器官的质粒型全长cDNA文库，初始文库滴度为3×10^6，插入片段平均长度大于1kb；随机挑取2004个阳性克隆进行5'EST测序，获得高质量序列1758条，经拼接获得1365条单基因簇，其中跨叠群175个和单条序列1195个；经ORF寻找共获得有效ORF1283条；经COG分析EST序列编码的蛋白质被分为22类；经Blast分析后，获得一批花色、花器官发育、花期调控以及其它育种价值基因（包括cDNA全长或片段）。

Microarray technique was applied to look into the gene expression profiles. Ox-LDL induced HAEC apoptosis by inducing many redox- and apoptosis-related genes. Sal B prevented the ox-LDL induced endothelial damage and even induced endothelial cell proliferation.

本计划亦探讨丹参酚酸 B 抑制氧化低密度脂蛋白所造成内皮细胞的损伤与细胞附著分子表现的作用机转，亦引入微矩列技术以探讨基因表现差异之谱型，氧化低密度脂蛋白诱导许多氧化还原与细胞凋亡相关基因，丹参酚酸 B 可保护内皮细胞损伤甚至促进其增生。

Do you know, i need you to come back

你知道吗，我需要你回来

Yang yinshu、Wang xiangsheng、Li decang,The first discovery of haemaphysalis conicinna.

1〕 杨银书，王祥生，李德昌。安徽省首次发现嗜群血蜱。