基因型

Experiments show that Ang Ⅱ activates JNK mediated by AT〓, and JNK increases transcription activity of c-Jun by phosphorylating c-Jun amido-terminal, and induces expression of c-Fos gene. c-Jun and c-Fos form transcriptional factor activated protein-1 complex. AP-1 may stimulates genes which correlate with cardiovascular remodeling expression, such as transforming growth factor, collagen type Ⅰ and Ⅲ, skeletal muscle α-actin,β-MHC, atrial natriuretic factor.

实验表明，在心肌和血管平滑肌细胞Ang Ⅱ通过AT〓介导激活JNK；JNK通过磷酸化c-Jun氨基末端增加c-Jun的转录活性并诱导c-Fos基因表达，c-Jun和c-Fos蛋白形成转录因子复合物激活蛋白-1(AP-1)，并刺激各种心血管重塑相关基因如转化生长因子-β1(TGF-β1)、Ⅰ，Ⅲ型胶原、骨骼肌α-actin、β-MHC(β-myosin heavy chain，β-肌球蛋白重链)、心钠素的表达。

There is a tendency that goat breeds with higher T frequency have lower adult body weight.It could be inferred that the 5701G＞T in Agouti gene exon 4 might be related with the growth development of goat.

聚类分析也基本符合毛色表型的分类，并且在不同的群体中，随着T等位基因频率的升高，其成年体重降低，这可能是由于Agouti基因外显子4中的5701G＞T位点与山羊的生长速度有关。

114 HCV patients, according to the history of alcohol abuse, were divided into the alcohol group and nonalcohol group. The genotypes of HCV RNA in the two groups were performed by gene chip technique.

收集CHC患者114名，分为嗜酒组和非嗜酒组，以基因芯片技术对2组患者进行HCV RNA基因分型。

To investigate the genetic polymorphism of nine short tandem repeat loci in Han population of Southern China. The 9 STR loci (D11S2368, D12S391, D13S325, D18S1364, D22-GATA198B05, D6S1043, D2S1772, D7S3048, D8S1132) were amplified with STR_Typer_10_v1 kit for 1619 unrelated individuals of Han population in Southern China. The PCR products were analyzed with 3100 genetic analyzer and GeneMapper ID 3.1v software. The forensic efficiency parameters were calculated by PowerState V12.xls and the Hardy-Weinberg equilibrium was tested with Arlequin 3.11v software.

用STR_Typer_10_v1荧光标记试剂盒，对1 619例中国南方汉族无关个体的9个STR基因座(D11S2368，D12S391，D13S325 D18S1364，D22-GATA198B05，D6S1043，D2S1772，D7S3048，D8S1132)进行扩增，用AB公司3100遗传分析仪和GeneMapper 3.1v软件作STR分型，用PowerState V12.xls分析软件进行等位基因频率和法医学常用参数统计分析，用Arlequin 3.11v软件包作Hardy-Weinberg equilibrium平衡检验。

Methods The 9 STR loci (D11S2368, D12S391, D13S325, D18S1364, D22-GATA198B05, D6S1043, D2S1772, D7S3048, D8S1132) were amplified with STR_Typer_10_v1 kit for 1619 unrelated individuals of Han population in Southern China. The PCR products were analyzed with 3100 genetic analyzer and GeneMapper ID 3.1v software. The forensic efficiency parameters were calculated by PowerState V12. xls and the Hardy-Weinberg equilibrium was tested with Arlequin 3.11v software. The genetic polymorphism of 9 STR loci in Han population of Southern China was quite high.

用STRT_yper_10_v1荧光标记试剂盒，对1619例中国南方汉族无关个体的9个STR基因座(D11S2368， D12S391， D13S325 D18S1364， D22-GATA198B05， D6S1043， D2S1772， D7S3048， D8S1132)进行扩增，用AB公司3100遗传分析仪和GeneMapper 3.1v软件作STR分型，用PowerStateV12.xls分析软件进行等位基因频率和法医学常用参数统计分析，用Arlequin 3.11v软件包作Hardy-Weinberg equilibrium平衡检验。

ABSTRACT］ Objective To observe the efficacy and side effects of combined therapy with alltrans retinoic acid, arsenic trioxide (As2O3) and chemotherapeutics for newly diagnosed acute promyelocytic leukemia.

急性早幼粒细胞白血病是急性髓系白血病中的一种独特类型(M3型)，以特异的染色体易位t(15，17)(q22，q21)为特征，形成PMLRARa融合基因，该融合基因是APL发病的分子基础和分子标志。

The results show that all the hmgr genes from pigs, cattle and chickens are astable enzyme proteins with the same gene sequence characteristics and encoding protein and physical and chemical properties; all the amino acid sequences have a high degree of homology, containing two conservative HMG-CoA binding motifs and two NADPH binding motifs; all the amino acid sequences, containing signal peptide, are secreted proteins; they are all hydrophobic transmembrane proteins with five transmembrane domains; random coil and α-helix are the main structural elements in the HMGR polypeptide chain; all the predictions of three-dimensional structure are V- shaped; there are more closer evolution relationship between the HMGR gene from pigs and cattle.

结果表明：猪、牛和鸡HMGR基因序列特点及编码蛋白质理化性质基本相同，均属不稳定类酶蛋白；保守结构域氨基酸序列具有高度的同源性，均含有保守的2个β-羟基-β-甲基戊二酸单酰辅酶A结合基序和2个还原性烟酰胺腺嘌呤二核苷酸结合基序；均有信号肽，属分泌型蛋白质；属于跨膜的疏水性蛋白，均有5个跨膜结构域；无规则卷曲和α-螺旋是HMGR多肽链中的主要结构元件；三维结构预测都呈"V"字形；猪和牛HMGR基因的进化关系最近。

So the aim of our study was to investigate the relationship of candidate genes polymorphism and atopic disease in Taiwan.

因此我们的研究目的为探讨候选基因之基因多型性和台湾人过敏疾病的关系。

After repeat 10 generations backcross to get pure B6-strain background Gas7 knockout mice.

接著将Gas7基因剔除鼠和野生型的B6老鼠做交配，以期得到纯品系的Gas7基因剔除鼠。

The researches on chromosome shape, structure, and banding pattern are foundation of gene mapping research.

研究染色体的形态、结构，尤其是带型，是基因定位与基因图谱研究的基础工作。

Do you know, i need you to come back

你知道吗，我需要你回来

Yang yinshu、Wang xiangsheng、Li decang,The first discovery of haemaphysalis conicinna.

1〕 杨银书，王祥生，李德昌。安徽省首次发现嗜群血蜱。