基因型

Human/rat homology collagen type I siRNA plasmid not only direct repress collagen type I gene expression in rat inesangial cells, but also have the same inhibition action of TGF-β1 induced overexpression of collagen type Ⅰ.

本实验构建的人鼠同源Ⅰ型胶原siRNA质粒，在大鼠系膜细胞内不仅能够直接抑制Ⅰ型胶原的基因表达，而且对TGF-β1诱导的I型胶原表达增加同样具有较好的抑制作用。

In them,as for the mean value calculated by least square method,AA maximum,AB next and BB minimum.In addition,GH3 obviously affected the body length,AA maximum, AB next and BB minimum.

运用最小二乘法对三个牦牛群体进行分析发现GH基因第3外显子对体重有显著影响(P＜0.05)，其中，最小二乘法得出的均值，AA型最大，AB型次之，最小的为BB型。

The nucleoprotein is one of the most conservative constructive protein and has higer homology with nucleoprotein of influenza A viruses.

禽流感病毒核蛋白基因在A型流感病毒中同源性较高，保守性强，核蛋白具有型特异性，是流感病毒划分为A、B、C型的主要依据。

The Ids RNA or siRNA obtained by said invention is mixed with hepatitis B virus expression vector in proper proportion, and injected into the mouse body by vane caudalis hydraulic pressure method, and its result shows that the non-homologous sequence IdsRNA and siRNA basically do not inhibit the replication of hepatitis B virus in mouse body, and these RNA molecules are mixed with hepatitis B virus gene.

将本发明得到的ldsRNA或siRNA以适当的比例与乙型肝炎病毒表达载体混合，并用尾静脉液压法注射到小鼠体内。结果显示非同源性序列ldsRNA和siRNA基本不抑制乙型肝炎病毒在小鼠体内的复制，而与乙肝病毒基因同源性的ldsRNA和siRNA可以有效抑制乙型肝炎病毒在小鼠体内的感染复制，抑制率高达90％以上。

Root hairs of wild type were intensely induced in the presence of NAA, while the gls mutant was insensitive to NAA induced root hair initiation; Lateral roots of the wild type were dramatically decreased when treated with 2,4-D, while the gls mutant was insensitive to 2,4-D induced reduction in lateral root initiation; The seminal root length of wild type showed no obvious changes by the treatment with IAA, but the gls mutant was supersensitive to IAA with dramatic reduction in seminal root length, suggesting that the interactions of GLS gene with different hormones may involve different mechanisms.

外源NAA 处理强烈诱导野生型根毛发生，而gls突变体则不敏感；外源2，4-D处理，野生型侧根急剧减少，gls突变体则不敏感；外源IAA处理，野生型种子根长变化不明显，而gls突变体超敏，种子根长迅速变短，表明GLS基因与不同激素有不同的互作机制。

In fish and amphibia, the transition from maternal gene transcription to zygotic transcription happens during the time of midblastula formation, this stage is named by midblastula transition, at this period, embryo cell cycle composition changes, it is the first time to G1 time appearance, the cell cycle timelimit lengthens and the cell division synchronism loses, the large quantities of zygotic gene transcription starts.

鱼类和两栖类由母型调控向合子型调控过渡发生在中囊胚形成阶段，称为中囊胚过渡(midblastula transition，MBT)，胚胎细胞周期时相的组成在此期间发生变化，首次出现G1期，周期时限延长，细胞分裂的同步性丧失，大批合子型基因活化转录也在此时开始。

Out of all P16 gene changes,4 were dot mutation,2 were deletion and 1 was heterozygous.

结果16例胰腺组织标本中有7例检测出存在着P16基因的改变，4例标本为点突变，2例标本为缺失型改变，还有1例患者存在着野生型与缺失型同时存在的杂和状态。

Paper 2:Mutation analysis of EDA gene in Chinese families with X-linked hypohidrotic ectodermal dysplasiaX-linked hypohidrotic ectodermal dysplasia(XLHED,MIM305100) is a recessive disease characterized by severe hypohidrosis,hypotrichosis and hypodontia.

论文二X连锁无汗/少汗型外胚层发育不良中EDA基因致病突变鉴定X连锁隐性无汗/少汗型外胚层发育不良(X-linked anhidrotic/hypohidroticectodermal dysplasia，XLHED；MIM305100)是无汗/少汗型外胚层发育不良(anhidrotic/hypohidrotic ectodermal dysplasia，EDA)中最常见的一种，约占95%。

Our previous studies have shown that ubiquitous overexpression of HmgD caused hemocytes proliferation and the formation of melanotic tumors in the Drosophila larvae. To clarify the mechanism of melanotic tumors appearance,we also generated RT-PCR analysis to test the transcriptional changes of PPAE and Spn27A,which encode the key factors in the phenoloxidasecascade pathway from larvae samples of mid-third instar,late-third instar and prior to pupation relative to wild type flies.Our result showed that in the HmgD overexpression mid-third instar larvae,the expression level.of Spn27A was lower than wild type,otherwise the expression level of PPAE was higher than wild type.It suggests that overexpression of HmgD affects the PO cascade pathway.

本研究组前期工作发现，过量表达HmgD引起果蝇幼虫体内血细胞增生，并出现黑色素瘤，为探讨HmgD过量表达导致了血细胞增生即形成黑色素瘤的分子机制，本研究分别提取三龄中期、后期和相对于野生型化蛹前时刻的幼虫的RNA，首先检测了编码酚氧化酶级联反应途径中的两个关键基因PPAE，Spn27A在突变体中的转录发生变化，结果发现，Spn27A在三龄中期的表达量低于野生型，而PPAE的表达高于野生型，表明过量表达HmgD影响了酚氧化酶级联反应途径，低水平的Spn27A不足以抑制PPAE的活性，活化的PPAE催化了PPO的活性，使其转变成有活性的PO，从而促进黑色素的生成，使果蝇体内产生黑色素瘤。

Besides, it is consistent with the asymmetrical gene flow from monogynous to polygynous populations through males in monogyne..Therefore, the cuticular chemicals can not be cluster well between monogynous and polygynous ants, and the variance of chemicals of the latter is higher than those of the former.

由於这些化学物质的合成受到遗传影响，这种现象显示两个涵义，第一个是单蚁后社会型的工蚁对其他蚁后有强烈的排他性而造成的选汰压力导致其遗传结构上较为均质，另一个涵义显示单蚁后社会型的遗传组成可藉由雄蚁将其基因带入多蚁后社会型的遗传组成，但反之则不然；因此二者之间无法分群，且后者的遗传变异较前者为大。

However, as the name（read－only memory）implies, CD disks cannot be written onorchanged in any way.

然而，正如其名字所指出的那样，CD盘不能写，也不能用任何方式改变其内容。

Galvanizes steel pallet is mainly export which suits standard packing of European Union, the North America. galvanizes steel pallet is suitable to heavy rack. Pallet surface can design plate type, corrugated and the gap form, satisfies the different requirements.

镀锌钢托盘多用于出口，替代木托盘，免薰蒸，符合欧盟、北美各国对出口货物包装材料的法令要求；喷涂钢托盘适用于重载上货架之用，托盘表面根据需要制作成平板状、波纹状及间隔形式，满足不同的使用要求。