基因型

Five patients were alive, they appeared progressive muscular atony and atrophy, especially in shoulder and pelvic girdle, with normal serum creatine kinase and troponin T examination; some patients appeared heart enlargement, arrhythmia, and heart failure.

结论该家系符合常染色体显性遗传的特点；根据患者临床及病理特点，诊断为肢带型肌营养不良症伴心肌损害，以肢带型肌营养不良症ⅠB型可能性大；进一步明确其基因分型需行分子遗传学检查。

HEPATOLOGY DIGEST : Are there any differences in genotype 1, 2 and 3 patients with HCV on treatment?

国际肝病》：关于基因1型、2型和3型丙型肝炎患者在治疗上有哪些不同之处呢？

P. denasta harbored the three chlorotypes, two of which were characteristic of its two parental species respectively. The third chlorotype was extensively distributed in seven of the ten P. densata populations analyzed, and might represent a mutation type or have been derived from an extinct parent. Population differentiation of P.

TT和GC分别是油松和云南松种特异性叶绿体单倍型，而在高山松群体里则三种单倍型均有分布，而且TC单倍型广泛地分布在7个杂种群体中，该单倍型很可能来源于点突变或第三个已灭绝的亲本。rbcL基因检测到的高山松群体分化系数很高（G〓=0.533）。

There is still no consensus on the expression of the two isoforms in the human prostate and their cellular locations are also controversial. It is not known to which extent each of these isozymes contributes to overall enzyme activity in different prostatic tissues. In an attempt to elucidate which isoform of the 5α-reductases is responsible for the metabolism of T in normal and diseased human prostate, we performed qualitative and semi-quantitative studies of both enzymes in normal, benign hyperplastic and adenocarcinomatous human prostate tissues by RT-PCR and Immunohistochemistry methods.

现已成功地克隆出编码Ⅰ型及Ⅱ型5α-还原酶的基因，关于这两型5α-还原酶在前列腺组织及不同类型细胞中的存在、分布情况及其对组织中睾酮代谢各自所起的作用仍存在许多争议，为此我们应用RT-PCR及免疫组化方法对国人正常、良性增生以及前列腺癌组织中两型5α-还原酶的表达进行了定性和半定量研究。

Results 10 strains of salmonella enteritidis appear multi-antibiotics resistance. These strains were subtyped into 3 groups A, B, C according to the electrophoresis profiles sinilarity 85% standard or above, including 2 strains, 6strains and 2 strains respectively.

结果 药敏呈现出多重耐药；基因谱系与聚类分析可将菌株分为3大类，扩增片段长度为250bp~2000bp，在85%的同源度上可分为A、B、C等3个型，其中A型2株，B型6株，C型2株。

We had 6 heliotypes from INRA124 locus and UMN2404 locus. H1 heliotype had a high frequency in Nanyang cattle and Luxi cattle, and H2 heliotype had a high frequency in Jinnan cattle and Qinchuan cattle.

两个微卫星位点等位基因构建六种单倍型，其中H1 型在南阳牛和鲁西牛占主要地位，H2 型在秦川牛和晋南牛占主要地位，在南阳牛和鲁西牛没有检测到H6 型。

We have sequenced the coding region of Cx26 gene from 190 Taiwanese patients with prelingual deafness and 120 unrelated normal individuals. In the deaf patients, three mutations were found: missense mutation, 551G to A and deletion, 235delC and 299-300delAT.

收集120位听力正常人及190位听障孩童对Cx26基因进行多型性比对发现有5种多型性，其中有4种多型性是之前已被发表的：79G→A(V27I)、109G→A(V37I)、341A→G(E114G)及608T→C(I203T)，另发现有一个新的多型性(558G→A)。

Darier's disease is an uncommon autosomal dominant genodermatosis. About 10% Darier's diseases present a mosaic form with linear distribution following Blaschko's lines. This unusual forms were named localized, linear, unilateral, segmental or zosteriform Darier's disease.

Darier's disease是一种罕见之遗传性皮肤病，大约百分之十患者呈现基因镶嵌形式，其皮肤病灶会沿著布拉许口氏线分布，这些不寻常之形式特曰局限型，线型，单侧型，分节型或带状型Darier's disease。

"Because of the powerful genetic effects on incubation periods in laboratory animals, vCJD patients identified could represent a distinct genetic subpopulation with unusually short incubation periods for BSE prions, with vCJD so far occurring predominantly in those individuals with short incubation time alleles at these multiple genetic loci, in addition to having the homozygous PRNP genotype of codon 129 methionine," they write.

因为动物实验表现出基因对潜伏期的强力影响，鉴定vCJD病患表现出清楚的基因次族群和BSE传染性蛋白质的不寻常短潜伏期；vCJD病患目前显著地发生在短潜伏期对偶基因者，密码子129蛋氨酸的PRNP 基因是同型合子。

Genotyping data from 13 plasma donors and 23 patients with chronic hepatitis C showed that 29 (80.55%) were 1b, 5 (13.89%) were genotype 2, and 2 (5.56%) remained untyped.

对13例HCV RNA阳性的单采浆供血员和23例慢性丙型肝炎病人HCV基因分型结果表明，29例(80.55%)为1b型，5例(13.89%)为 2型，另2例(5.56%)不能被分型。

Do you know, i need you to come back

你知道吗，我需要你回来

Yang yinshu、Wang xiangsheng、Li decang,The first discovery of haemaphysalis conicinna.

1〕 杨银书，王祥生，李德昌。安徽省首次发现嗜群血蜱。