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Antigene peptide nucleic acid specifically inhibits MYCN expression in human neuroblastoma cells leading to cell growth inhibition and apoptosis Roberto Tonelli,Stefania Purgato,Consuelo Camerin,Raffaele Fronza,Fabrizio Bologna,Simone Alboresi,Monica Franzoni,Roberto Corradini,Stefano Sforza,Andrea Faccini,Jason M. Shohet,Rosangela Marchelli,and Andrea Pession Department of Pediatrics, University of Bologna,Sant'Orsola-Malpighi Hospital, Bologna, Italy; Department of Organic and Industrial Chemistry, University of Parma, Parma,Italy; and 3Center for Cell and Gene Therapy, Texas Children's Cancer Center, Baylor College of Medicine, Houston, Texas Abstract We developed an antigene peptide nucleic acid for selective inhibition of MYCN transcription in neuroblastoma cells, targeted against a unique sequence in the antisense DNA strand of exon 2 of MYCN and linked at its NH2 terminus to a nuclear localization signal peptide.

抗原肽核酸抑制MYCN具体表达的神经母细胞瘤细胞,导致细胞生长的抑制和凋亡罗伯托利,斯特凡Purgato ,苏埃洛卡默琳,拉菲尔Fronza ,梅奥尼博洛尼亚,西蒙娜Alboresi ,莫妮卡弗兰索尼,罗伯托Corradini ,斯特凡诺斯福尔扎,安德烈Faccini ,杰森先生Shohet , Rosangela Marchelli ,和安德烈Pession儿科,博洛尼亚大学,圣' Orsola -马尔皮基医院,博洛尼亚,意大利;有机部和工业大学化学帕尔马,帕尔马,意大利和3Center的细胞和基因治疗,德州儿童癌症中心, Baylor医学院,得克萨斯州休斯敦摘要我们开发了一种抗原肽核酸的选择性抑制神经母细胞瘤MYCN转录细胞,针对一个独特的序列反义DNA链的第2外显子,并与在MYCN 其氨基端为核定位信号肽。

The presence of guttural sounds, diacritic aspirations, epenthetic and servile letters in both languages: their antiquity, both having been taught on the plain of Shinar 242 years after the deluge in the seminary instituted by Fenius Farsaigh, descendant of Noah, progenitor of Israel, and ascendant of Heber and Heremon, progenitors of Ireland: their archaeological, genealogical, hagiographical, exegetical, homiletic, toponomastic, historical and religious literatures comprising the works of rabbis and culdees, Torah, Talmud, Massor, Pentateuch, Book of the Dun Cow, Book of Ballymote, Garland of Howth, Book of Kells: their dispersal, persecution, survival and revival: the isolation of their synagogical and ecclesiastical rites in ghetto S.

218两种语言都有喉音、区分的气音、增音以及附属性的字母。两种都是古老的语言,大洪水后二四二年,费尼乌斯。法赛在西纳尔平原所创办的学院就开了这两种语言的课程。他是以色列民族的祖先挪亚的后裔;又是爱尔兰民族的祖先埃贝尔与赫里蒙的始祖。用这两种语言写成的考古学的、系谱学的、圣徒传记学的、注释学的、布道术的、地名研究的、历史的以及宗教方面的著作,其中包括犹太法学博士和神仆团团员的著述:托拉、《塔木德》、马所拉本、《五经》、《牛皮书》、《巴利莫特书》、《霍斯饰本》、《凯尔斯书》,记述这两个民族的离散:,受迫害,幸存,复兴。

Edmonds refers to ATC and AIPAC as "sister organizations." The group's founders include a number of prominent Americans involved in the Israel-Turkey relationship, notably Henry Kissinger, Brent Scowcroft, Richard Perle, Douglas Feith, and former congressman Stephen Solarz.

埃德蒙兹指ATC与aipac为"姐妹组织"集团的创办人包括一些著名的美国人参与了以色列同土耳其的关系,尤其是基辛格,斯考克罗夫特,理查德珀尔,道格拉斯费斯和前国会议员斯蒂芬索拉兹等。

My Blythe kinfolk were descendants of both Henry III's sister Eleanor and her husband, Simon de Montfort, Earl of Leicester, who defeated the king in battle and forced him to accept the most representative parliament up to that time.

我的布莱斯宗族是亨利三世姐姐埃莉诺和丈夫莱切斯特伯爵西蒙。德蒙特福特的后裔,他在战场上打败了国王,迫使英王接受了在当时为止最有代表性的议会。

Edwin Montal would now meet Erik Hjorleifson for the right to oppose Felix Beardy in the final.

埃德温蒙塔尔现在满足埃里克hjorleifson为有权反对费利克斯beardy在最后。

In England, the Elizabethan era marked the beginning of the English Renaissance with the work of writers William Shakespeare , Christopher Marlowe , Edmund Spenser , Sir Thomas More , Francis Bacon , Sir Philip Sidney , John Milton (who is known as perhaps last of the renaissance artists), as well as great artists, architects (such as Inigo Jones who introduced Italianate architecture to England), and composers such as Thomas Tallis , John Taverner , and William Byrd .

在英格兰,伊丽莎白时代标志著英格兰文艺复兴的开端,那时流行着作家莎士比亚,克里斯托弗·马洛,埃德蒙·斯宾塞,托马斯·莫尔,培根,菲利普·西德尼,米尔顿(他被认为是文艺复兴时期最后一个艺术家),许多的艺术家,包括建筑师(例如将意大利式建筑引进英国的伊尼戈·琼斯)和作曲家,例如托马斯·塔利斯,约翰·塔弗纳,威廉·伯德。

TITLES SOLO CONTEST - Winner of European 1vs1 Ultimate B-Boy session 2 - Germany 1998 - Winner of the best B-Boy at BOTY Scandinavia Sweden 2001 - Winner of the 1vs1 UK-CHAMPIONSHIP - London 2001 - Winner of the TV -show STAR SEARCH - Denmark 2004 - 4th place - REDBULL BC-ONE - Switzerland 2004 CREW CONTEST - Winner of the Scandinavian BOTY 2001.2004.2005 - Winner of the Scandinavian CIRCLE REVOLVING 2004 - Winner of the URBAN GAMES London 2006 - Winner of the HIPHOP CONECTION Italy 2006 - Winner of the BLOCK PARTY Monpellier France 2006 - Winner of the BREAKDANCE SESSION Poland 2004 - Winner of the FLOOR WARS Copenhagen Denmark 2006 - Winner of BOTY Scandinavia 2005 JUDGE - BATTLE MASTER Korea 2004 - B-BOY HODOWN Texas 2005 - THE MOST WANTED Catania Italy 2005 - CARA A CARA Valencia Spain 2005 - BOTY Poland 2005 - BOTY East Germany 2006 - BOTY France 2006 - BOTY Korea 2006 - GAMES ON DA FLOOR Igualada Spain 2006 - REDBULL BEAT BATTLE London 2006 - UK B-BOY CHAMPIONSHIPS 2006 - RED BULL BC ONE, Brazil, 2006

个人比赛奖项:- 1998年德国,欧洲极限单人对决b-boy第2季冠军- 2001年瑞典斯堪的纳维亚BOTY街舞比赛年度最佳的B -boy - 2001年英国伦敦锦标赛担单人决冠军- 2004年丹麦寻找明星电视节目选秀冠军- 2004年瑞士红牛一对一斗舞比赛第四名团体竞赛奖项:-斯堪的纳维亚BOTY街舞比赛2001.2004.2005年度冠军- 2004年的斯堪的纳维亚旋转舞比赛冠军- 2006年伦敦城市运动会冠军- 2006年意大利说唱嘻哈接龙冠军- 2006年蒙比利埃街区音乐派对冠军- 2004年波兰霹雳舞赛季冠军- 2006年丹麦哥本哈根击倒作战赛冠军- 2005年斯堪的纳维亚BOTY街舞比赛冠军曾担任的评审:- 2004年韩国战斗大师- 2005年得克萨斯州HODOWN b-boy - 2005年意大利卡塔尼亚龙虎新风云- 2005年西班牙瓦伦西亚闪舞- 2005年波兰博特街舞- 2006年东德博特街舞- 2006年法国博特街舞- 2006年韩国博特街舞- 2006西班牙伊瓜拉达游戏地板- 2006年伦敦红牛对决战- 2006年英国b-boy锦标赛- 2006年红牛斗舞比赛

I also published horror or dark fantasy by Carol Emshwiller, Jack Dann, Jack Cady, Jonathan Carroll, Greg Bear, Pat Cadigan, Stephen King, Lucius Shepard, Edward Bryant, Scott Baker, Simon Ings, Harlan Ellison (his "Mefisto in Onyx" won the Stoker).

我还发表过卡罗尔·艾姆什维勒、杰克·唐恩、杰克·凯迪、乔纳森·卡罗尔、格雷格·贝尔、帕特·凯迪根、斯蒂芬·金、卢修斯·谢帕德、爱德华·布莱恩特、斯科特·贝克、西蒙·英格斯、哈兰·埃里森(《 Mefisto in Onyx 》获得布莱姆·斯托克奖)的恐怖和黑暗奇幻小说。

10 What let his opponent down, according to Leslie Zebrowitz, a psychologist at Brandeis University and Joann Montepare of Emerson College, was his " neotenous[7] facial anatomy" or, to put it more simply, his "babyface".

布兰德斯大学心理学家莱斯利&泽布罗维茨和埃默森学院的乔安&蒙特帕里认为,费恩格德的对手之所以落败,是因为他&稚气未脱的面部特征&,或者说的直接一点就是&他长了一副娃娃脸&。

What let his opponent down , according to Leslie Zebrowitz, a psychologist at Brandeis University and Joann Montepare of Emerson College, was his " neotenous[7] adj.幼稚的,幼态的 facial anatomy 剖析,解剖学" or, to put it more simply , his "babyface".

布兰德斯大学心理学家莱斯利·泽布罗维茨和埃默森学院的乔安·蒙特帕里认为,费恩格德的对手之所以落败,是因为他&稚气未脱的面部特征&,或者说的直接一点就是&他长了一副娃娃脸&。

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But we don't care about Battlegrounds.

但我们并不在乎沙场中的显露。

Ah! don't mention it, the butcher's shop is a horror.

啊!不用提了。提到肉,真是糟透了。

Tristan, I have nowhere to send this letter and no reason to believe you wish to receive it.

Tristan ,我不知道把这信寄到哪里,也不知道你是否想收到它。