埃尔默洛

Antigene peptide nucleic acid specifically inhibits MYCN expression in human neuroblastoma cells leading to cell growth inhibition and apoptosis Roberto Tonelli,Stefania Purgato,Consuelo Camerin,Raffaele Fronza,Fabrizio Bologna,Simone Alboresi,Monica Franzoni,Roberto Corradini,Stefano Sforza,Andrea Faccini,Jason M. Shohet,Rosangela Marchelli,and Andrea Pession Department of Pediatrics, University of Bologna,Sant'Orsola-Malpighi Hospital, Bologna, Italy; Department of Organic and Industrial Chemistry, University of Parma, Parma,Italy; and 3Center for Cell and Gene Therapy, Texas Children's Cancer Center, Baylor College of Medicine, Houston, Texas Abstract We developed an antigene peptide nucleic acid for selective inhibition of MYCN transcription in neuroblastoma cells, targeted against a unique sequence in the antisense DNA strand of exon 2 of MYCN and linked at its NH2 terminus to a nuclear localization signal peptide.

抗原肽核酸抑制MYCN具体表达的神经母细胞瘤细胞，导致细胞生长的抑制和凋亡罗伯托利，斯特凡Purgato ，苏埃洛卡默琳，拉菲尔Fronza ，梅奥尼博洛尼亚，西蒙娜Alboresi ，莫妮卡弗兰索尼，罗伯托Corradini ，斯特凡诺斯福尔扎，安德烈Faccini ，杰森先生Shohet ， Rosangela Marchelli ，和安德烈Pession儿科，博洛尼亚大学，圣' Orsola -马尔皮基医院，博洛尼亚，意大利；有机部和工业大学化学帕尔马，帕尔马，意大利和3Center的细胞和基因治疗，德州儿童癌症中心， Baylor医学院，得克萨斯州休斯敦摘要我们开发了一种抗原肽核酸的选择性抑制神经母细胞瘤MYCN转录细胞，针对一个独特的序列反义DNA链的第2外显子，并与在MYCN 其氨基端为核定位信号肽。

The South West is a region of contrasts对比,对照,(对照中的差异-- Wiltshire, where South West England begins less than an hour from London; Gloucestershire, home to the Forest of Dean and the Cotswolds; Dorset, an area of outstanding natural beauty and bordered by the Jurassic coastline; Bristol and Bath, with centuries of history and culture; Somerset, a mix of heather covered Exmoor and the levels of Devon, with two coastlines and wide open spaces; Cornwall, bounded by the sea and steeped in Celtic tradition with the delightful Scilly Isles, each with its own features and attractions.

西南部的景色对比鲜明威尔特郡是西南部的开端，离伦敦不到一小时路程；格洛斯特郡拥有迪恩森林和科茨沃尔德丘陵；多塞特郡是杰出自然风景区，与侏罗纪海岸线接壤；布里斯托尔和巴斯享有几个世纪的历史与文化；萨默塞特郡有石楠覆盖的埃克斯穆尔和层层叠叠的塞奇穆尔高沼；德文郡的两条海岸线和广阔空间相互衬托；康沃尔郡以海为界，凯尔特传统根深蒂固，锡利群岛美丽如画；每个郡都各有特色。

Painters, adventurers and writers like Melville, Conrad, R.L. Stevenson, Pierre Loti, Rupert Brooke, Somerset Maugham, Charles Nordhoff, James Hall and many others made Tahiti famous with their paintings and stories.

画家、探险家和作家，如梅尔维尔、康拉德、史蒂文森、皮埃尔·洛提、鲁伯特·布鲁克、萨默塞特·毛姆、查尔斯·诺德霍夫、詹姆士·霍尔，还有其他很多人都通过自己的绘画或写作让塔希提闻名于世。

You can begin by checking out UK's Premier Disabled dating website which has thousands of members from everywhere in the UK, including Avon, Bedfordshire, Royal Berkshire, Birmingham, Buckinghamshire, Cambridgeshire, Central Yorkshire, Cheshire, Cleveland, Cornwall, City of Coventry, Cumbria, Derbyshire, Devon, Dorset, Durham, East Lancashire, East Sussex, Essex, Gloucestershire, Greater London (Middlesex West, North, North East, South, South East, South West), Greater Manchester, Hampshire, Hereford and Worcester, Hertfordshire, Humberside, Isle of Wight, Kent, Leicestershire, Lincolnshire, Merseyside, Norfolk, North Yorkshire, Northamptonshire, Northumberland, Nottinghamshire, Oxfordshire, Rutland, Shropshire, Solihull, Somerset, South Yorkshire, Staffordshire, Suffolk, Surrey, Warwickshire, West Lancashire, West Mercia, West Sussex, West Yorkshire and Wiltshire.

你可以开始检查出英国的残疾约会网站，其中有数以千计的成员来自世界各地，在英国，包括雅芳，贝德福德郡的皇家伯克郡，伯明翰，白金汉郡，剑桥郡，中部约克夏，柴郡，克里夫兰骑士，康，市考文垂，坎伯里亚郡derbyshire ，德文，多塞特，达勒姆，东兰开夏，东萨塞克斯，埃塞克斯，格洛斯特，大伦敦地区（的middlesex西部，北部，东北部，南部，东南，西南），大曼彻斯特，新罕布什尔，禧和伍斯特，赫特福德郡， humberside ，岛威特，肯特大学， leicestershire ，林肯郡，埃弗顿，诺福克岛，北约克郡， northamptonshire ， northumberland ，诺丁汉，牛津郡，应采， shropshire ， solihull ，萨默塞特，南约克郡，斯塔福德，萨福克，萨里， warwickshire ，西兰开夏，西麦西亚，西苏塞克斯，西约克郡和威尔特郡。

In the fall of 2001, Mr. Silverstein toured major European cities as a member of a piano quartet that includes Pierre-Laurent Aimard, pianist; Tabea Zimmermann, violist, and Jean-Guihen Queyras, cellist.

在2001年秋，西尔夫斯坦先生作为四重奏乐团的在欧洲主要城市举行了巡回演奏，乐团的其他成员是：钢琴家皮埃尔-洛朗·艾马尔、中提琴家齐默曼和大提琴家尚-古汉·奎拉斯

The writing may have been muddled but the message was clear. After helping the Azzurri to FIFA World Cup glory, Pirlo is the new darling of Italian football. His face is blazoned across every billboard, his reputation bolstered by every mesmerising pass. Fans across the globe may find a small place in their heart for the Emersons and Claude Makeleles of this world but they usually reserve their true love for the entertainers such as Kak and Ronaldinho. With Pirlo, you buy one and get the other free.

也许其中的逻辑有些不清楚，但意思再明白不过了，在帮助意大利队获得世界杯冠军后，皮尔洛成为了意大利足球界的新宠，他的头像出现在每一块广告牌上，他的名声传播到任何一条蹊径上，现在很少有球迷在心中为防守悍将埃默森或者马克莱莱留有位置，他们大多喜欢娱乐性更强的卡卡或者罗纳尔迪尼奥，皮尔洛对球迷来说，则是买一送一。

But we don't care about Battlegrounds.

但我们并不在乎沙场中的显露。

Ah! don't mention it, the butcher's shop is a horror.

啊！不用提了。提到肉，真是糟透了。