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Expression of genes involved in the somatotropie,thyrotropic,and corticotropic axes during development of Langshan and Arbor Acres ChickensWe found an inverse expression profile between pituitary growth hormone and hepatic GH receptor mRNA(postnatal day 28[P28]-42),insulin-like growth factor-Ⅰand IGF-IR(P0-42),respectively.

狼山鸡和AA鸡胚胎时期和出生早期生长轴、甲状腺轴、肾上腺轴有关基因的表达本研究揭示了垂体中的生长激素和肝脏中的生长激素受体mRNA的表达趋势在出生后第28天(P28)到P42期间是相反的,而肝脏中的胰岛素样生长因子Ⅰ和IGF-Ⅰ的受体mRNA的表达在P0-P28期间是相反的。

RESULTS:After pinealectomized mice was irradiated WBI with 75 mGy X-rays,we found levels of plasma corticosterone increased obviously,and the effects of the proliferative reaction of splenocytes to ConA and spontaneous proliferation of thymocytes was found to be decrease. But injecting melatonin into pinealectomized mice or putting melatonin in the cultured cell,its immune functions might renew the enhancement.CONCLUSION:Melatonin of pineal gland might regulate the immunoenhancement induced by low dose radiation.MeSH Pineal body; Melatonin; Radiation; Corticosterone; Immunity,cellular

低剂量辐射(low dose radiation,LDR)全身照射(whole body irradiation,WBI)可引起免疫系统的兴奋效应,主要表现在以T淋巴细胞功能激活为主的细胞免疫和体液免疫功能的增强并可提高机体的抗瘤作用[4,5],在LDR诱发免疫功能增强的同时伴有下丘脑-垂体-肾上腺皮质系统功能下调等神经内分泌功能的改变,神经内分泌对免疫系统的调节可能是LDR免疫兴奋效应发生的必要条件,松果腺MLT与辐射免疫兴奋效应的关系值得研究。

It is very similar between the secretion of rat pancreatic β cells and gonadotropes in general. Their secretions is also very similar to those observed in other endocrine cells, such as adrenal chromaffin cells. This study further proved that the three phasic process of secretion are ubiquitous.

虽然具体的分泌特性有所不同,但大鼠胰腺β细胞与垂体促性腺激素细胞的分泌情况在总体上很相似,这与前人在其他细胞上的发现也非常相似,本文的实验进一步证实了这种三个阶段的分泌过程和机制在不同的细胞中是普遍存在的。

On the base of research, a new academic opinion was put forward firstly in-out country: as for series changes caused by psychiatry, the liver in TCM is the regulating core,"Live bears the dipersive effect" not only can unitarily regulate the HPAA, but also hold the material central neuro mechanism, which show the organic unification of part (central material brain machanism) and uitary.

在国内外首次提出新的学术观点:&对于情志因素引起的各种变化,肝是机体调节心理应激反应的核心;中医肝主疏泄调畅情志的功能在实现对下丘脑-垂体-肾上腺皮质系统的整体性调节上,还存在着一定的具体的中枢神经机制;在作用机理上体现出局部与整体的有机统一&。

Gangliosides antagonized the apoptosis induced by corticosteron, and the underlying mechanism is related to activiation of neuronal calcium signal cascade, promoting neurotransmitter release. Gangliosides also have an ability to promote the neuronal filopodia formation and may have a antidepressive-like neuroprotecive effect. 2. Theory study: We explained the clinical symptoms showed in the syndromes of deficiency of kidney-Yang and deficiency of kidney-Yin with modern scientific technical terms. Moreover, we supposed the location of kidney of traditional Chinese medicine may be in the hippocampus but not in the hypothalamus, which is also the centre of learning and memory.

鹿茸有效成分能够拮抗皮质酮诱导的神经细胞凋亡,其机制与影响钙信号途径、促进神经递质释放有关,鹿茸有效成分还能促进神经细胞丝状伪足生长,并且可能具有抗抑郁药样的神经保护作用。2、理论研究:用现代科学语言对肾阳虚证和肾阴虚证临床症状的病理生理机制进行合理的解释,提出中医肾脑相关理论实质假说,推测补肾中药的调控点应当在下丘脑—垂体—肾上腺轴的高级中枢海马,而非下丘脑。

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