垂体的

In the whole rats, the following tissues or organs were extracted and fixed in the most appropriated fixator (Bouin liquid or Formalin at 10%) then included in paraffin blocks : all the organs showing significant macroscopic lesions, encephalon (brain hemisphere, cerebellum and annular protuberance), spinal cord, sciatic nerve, salivary glands, esophagus, stomach, duodenum, jejunum, ileon, caecum and colon, rectum, liver, spleen, bone marrow, lymph node close to and at distance, thymus, heart, aorta, trachea, lungs, thyroid/parathyroid, surrenals, pancreas, hypophysis, kidney, bladder, gonad, uterus, mammary glands, epididymis, prostate, eyes, lachrymal glands, bones, skin, thigh muscle and implantation sites (2 per animal).

从整体大鼠内，下列组织或器官提取后用最适宜的固化剂（ Bouin 液或10%的甲醛溶液）进行固定，然后包入石蜡块内：所有显示有明显肉眼可见损害的器官、脑髓、脊髓、坐骨神经、唾液腺、食道、胃、十二指肠、空肠、回肠、盲肠、大肠、直肠、肝脏、脾、骨髓、近端和远端淋巴结、胸腺、心脏、主动脉、气管、肺、甲状腺/甲状旁腺、肾上腺、胰腺、垂体、肾、膀胱、性腺、子宫、乳腺、附睾、前列腺、眼睛、泪腺、骨骼、皮肤、股肌以及假体植入部位（每只动物2处）。

The culture medium is composed of human keratinocyte serum free culture medium +2.5 mg/L bovine pituitary lixivium +5 μg/L epidermal growth factor+438 mg/L glutamine, glutamine can promote the growth of the keratinocyte.

采用改良的无血清培养技术进行人体角质形成细胞的培养，培养基为人角质形成细胞无血清培养基+2.5 mg/L牛垂体浸出液+5 μg/L表皮生长因子+438 mg/L谷氨酰胺，其中谷氨酰胺能促进角质形成细胞的生长。

Bnormal MRI manifestations in all of the 20 cases with acquired hepatocerebral degeneration,in which T1WI demonstrated increased signal in hibateral lentiform nucleus (n=20),globus pallidus(n=17),surrounding mesencephalon red nucleus(n=15),and in anterior pituitary(n=4)While T2WI demonstrated no corresponding alteration in signal intensityConclusion Abnormal MR signal in the patients with acquired hepatocerebral degeneration has special features and MRI has right value for the diagnosis of this disease

全部病例均有完备的临床与MRI资料。结果：20例脑部均有阳性MRI表现，其中双侧、豆状核20例，苍白球17例，中脑红核周围15例，垂体前叶4例，表现为自旋回波序列T1WI为高信号，T2WI及FLAIR像无异常。结论：获得性肝性脑部变性的MRI征象具有特征性，MRI对该病的诊断有较高价值。

It has done a lot investigation on the microneurosurgery technique and monodrama operations, performed different kinds of complicated and difficult operations successfully such as resection of cranial basis tumors , cerebrovascular disease, resection of pituitary tumor by nose way , resection of spinal cord tumors, spinal cord congenital malformation .

是国内较早开展显微神经外科手术单位之一。在显微神经外科技术和微创手术方面做过许多研究，成功完成了各种神经外科疑难与复杂手术，如颅底肿瘤的显微手术、脑血管病的微创与介入手术、经鼻蝶入路垂体瘤切除手术、脊髓髓内肿瘤、脊髓先天性畸形的显微手术等。

BACKGROUND: The basic way for the releasing pattern of secretory granules of neurohypophysis is still not clear, neither is the extracellular normal transport route of neurohypophysis polypeptide hormones to enter the cerebrospinal fluid.

背景：神经垂体多肽激素分泌颗粒的释放形式和在细胞外正常转运途径的结构基础是以胞吐分泌方式还是浓度差因素影响而进入脑脊液的。

Two types of pituicytes and three types of neurosecretory fibers (A1, A2 and B) have been recognized in neurohypophysis. The neurosecretory terminals contain different diameter and shape of secretory granules.

神经垂体组织中存在2种类型的脑垂体细胞，并可以区分A1、A2和B 3种类型的神经分泌纤维，其终端轴突中具有不同直径和形态的分泌颗粒；B型纤维轴突中含有许多透明小囊泡。

The releasing pattern of secretory granules or polypeptide hormones of neurohypophysis involves a whole-releasing pattern together with granular membrane. After released into perivascular space, they enter easily into cerebrospinal fluid via interspace of tissue and epithelial openings rather than into blood circulation through the walls of capillaries, and then into the cerebrospinal fluid.

神经垂体多肽激素分泌颗粒的释放形式，存在一种连同颗粒被膜的整体释放；释放入血管周隙内的多肽激素或分泌颗粒，更易经组织间隙、囊上皮孔进入脑脊液，而非直接透过毛细血管壁进入血液循环再进入脑脊液中。

These results indicate that the expression of PrRP in hypothalamus,pituitary body,oblongata and thyroid gland may not be affected by the period of growth,that PrRP in adrenal gland maybe involved in regulating neuroendocrine and stress, and that PrRP in ovaries maybe promote the form of luteal cells,and further regulate endocrine of generation.

这些结果提示：小鼠下丘脑、垂体、延髓和甲状腺PrRP mRNA可能不受周期的影响，表达比较稳定；肾上腺PrRP可能参与神经内分泌和应激调节过程；卵巢PrRP可能参与促进黄体细胞的生成，从而对生殖内分泌起到一定的调节作用。

I have been trying all kinds of different therapies before to cure my pituitary gland disorder, but none of them has any positive effect.

以前，我一直在尝试各种不同的疗法来治愈我的垂体障碍，但没有人有任何积极的效果。

The main clinical manifestations are persistent polyuria, thirst and polydipsia due to the consequence of dehydration, which can results in some severe complications such as shock, mental retardation, growth retardation and pyelectasis.

临床上主要表现为脱水所致的多饮、多尿和烦渴等症状，若不能及时诊治，可以导致一些严重的并发症，如休克、智力障碍、生长发育迟缓、肾盂积水等并发症；若同时合并头颅鞍区肿瘤以及腺垂体功能低减等，则会危及患者的生命。

She gently rebuff ed him, but agreed that they could be friends

她婉言拒绝了，但同意作为朋友相处。

If in the penal farm, you were sure to be criticized.

要是在劳改农场，你等着挨绳子吧！