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Objective:To evaluate the examinational quality of dynamic contrast enhancement MRI and its effect in diagnosing pituitary microadenoma.

作者:崔海燕,田国才,黄胜,龚沈初,姜洪标,李小龙目的:评估MRI动态增强扫描的检查质量和其在垂体微腺瘤诊断中的价值

During the aging process, impulse frequency of hypothalamus、Pituitary Gonadotropic hormone secretetion decreases, amplitude of which decends, moreover decrease sexual gland's sensitiveness to gonadotrophic hormone.

在衰老过程中下丘脑、垂体促性腺激素分泌的脉冲频率减慢,幅度降低,也降低了性腺对促性腺激素的敏感性。

PX induces the synthesizing and releasing of CRH by CRHneurons increase, activates HPA axis through hypophyseal portal system, thenmelatonin supplementation can partly reverse the abnormality, which indicates pinealbody is one of the key factors to maintain the structural and functional stablity ofneuroendocrine-immune network

松果体摘除导致大鼠下丘脑室旁核CRH 神经元合成和释放CRH 增加,并通过垂体门脉系统激活整条HPA 轴,而补充外源性褪黑素后能在一定程度上逆转上述异常,表明松果体是神经——内分泌——免疫网络的结构和功能的重要稳定因素之一。

Pituitary adenomas are the most common intrasellar tumor of the adenohypophysis accounting for 10-15% of all intracranial neoplasms.

垂体腺瘤是最常见的鞍内肿块,几乎占所有颅内肿瘤的10-15%,微腺瘤比大腺瘤更常见,且更常见于育龄期妇女。

Objective Detecting the protein expression of c-fos、c-jun and c-myc so as to inquire into its relation with knubbly invasion.

目的 检测c-fos、c-jun、c-myc基因蛋白在垂体腺瘤中的表达,探讨它们与肿瘤侵袭性的关系。

Clinical symptoms appear mild because of part of secretion of thyroid hormone,but followed by other signs of pituitary hormone deficiency ,for example ,hypoglycemia,micropenis diabetics insipidus.

TSH和TRH分泌不足的患儿常保留部分甲状腺激素分泌功能,因此临床症状较轻,但常有其他其他多种垂体激素缺乏的症状如低血糖小阴茎或尿崩症等。

Objective To explore the relationship between IL-6 and an effect of neurotrophy on the nerve fibres in anterior pituitary.

目的 探测白细胞介素-6(IL-6)是否与垂体前叶中的神经纤维的营养效应有关。

Melatonin is a hormone produced by pineal gland. As a synchronizer of endocrine system bioclock in vertebrate, melatonin possesses many physiological activities,e.g. regulating the biologic rhythm according to photoperiod, by its receptors widely distributed in pituitary gland, hypothalamus, optomeninx, kidneys, skin and its appendages, etc.

褪黑素主要是由松果体合成的一种激素,作为脊椎动物内分泌系统生物钟的同步器,其受体广泛分布于垂体、下丘脑、视网膜、肾脏和皮肤及其附属器,有着多种生理活性,按光周期信号调节生物体昼夜节律和季节节律。

METHODS: the supernatants of cultured spleen's lymphocytes induced by ConA were injected into mice peritoneally,kinetics of plasma corticotropin releasing hormone,adrenocorticotropic hormone and corticosterone in mice were tested at different time (0.5,1,2,4,6 h),or tissue of hypothalamus pituitarium or adrenal was stimulated with supernatants induced by ConA,and the secretion of CRH, ACTH and CORT were observed.

采用ConA诱导淋巴细胞培养上清液给小鼠腹腔注射,测定不同时间(0.5,1,2,4,6 h)的小鼠血浆中CRH,ACTH,皮质酮产生的动力学,同时在体外用ConA诱导上清液分别与下丘脑,垂体,肾上腺组织共同培养后观察CRH,ACTH,CORT分泌情况。

Rats in control group and model group received 0.9% sodium chloride solution 10 mL/kg. Rats in compound danshen dripping pills group received 0.75% compound danshen dripping pills 10 mL/kg. Rats in Xintongzhi drop pill high dose group and Xintongzhi drop pill low dose group received 3.6%, 1.8% Xintongzhi drop pill 10 mL/kg, respectively. After 7 days except control group, myocardial ischemia models were established by ranine vein of hypophysin in other four groups. The changes of lactate dehydrogenase,α-Hydroxybutyrate Dehydrogenase, creatine kinase, creatine kinase MB and ECG were recorded in each groups.

正常组和模型组予0.9%氯化钠注射液,复方丹参滴丸对照组予0.75%复方丹参滴丸水溶液,心痛治滴丸高剂量组、心痛治滴丸低剂量组分别给予3.6%、1.8%的心痛治滴丸水溶液,各组均10 mL/kg,每日1次灌胃。7日后除正常组外,其余4组均采用垂体后叶素0.5 U/kg舌下静脉注射制备大鼠急性心肌缺血模型,并检测各组乳酸脱氢酶、α-羟丁酸酶、磷酸肌酸激酶及磷酸肌酸激酶同工酶和心电图的改变。

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