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Objective To analyze the mechanism of action of Fuzheng Qingre Decoction for radioactivity rectal injury by comparison of pathological change and tumor necrosis factor expression in intestinal mucosa of radiation proctitis rat.

目的 通过比较实验组和对照组放射性直肠炎大鼠模型肠黏膜的病理变化及肿瘤坏死因子-α表达分析清热扶正汤对放射性直肠损伤的作用机制。

The pathologic changes of fungal diseases in alimentary canal were tissue necrosis, ulcer formation and pseudomembranous inflammation.

其病变为消化道组织坏死、溃疡形成及假膜性炎症;炎细胞浸润不明显,且以单核细胞浸润为主;假膜性炎中有较多的中性粒细胞渗出,可能与某些细菌的混合感染有关系。

Maxillary central incisors had a slightly greater pulpal blood flow values than maxillary lateral incisors. The flow values from 15 teeth with necrotic pulp or pulpless teeth were significantly lower than that from the control teeth. Before therapy the values from 16 deep caries teeth were all higher than that from the control teeth. After therapy, most (15/16) of those values decreased to normal in three days. The value of one tooth with deep caries remained high, and one week later, the pulp became necrosis.

由死髓牙测得的流量值显著小于正常对照。16颗深龋患牙治疗前牙髓血流量皆高于正常对照组,治疗后有15颗患牙的血流量很快降至正常,有1颗患牙在治疗后血流量无明显变化,最终发生牙髓坏死。

The model of brain concussion of rat can be established successfully using iron pendulum hitting device; 2. The spatial learning and memory deficits of the rats are detected by MWM in early period post-BC(from 1 to 3 days after BC); 3. Pycnosis degeneration or necrosis neurons of the cerebral cortex, dorsal hippocampus, dentate fornix and brainstem reticular formation are identified in BC rats; 4. There are significantly changes in the number and activity of cholinergic neurons in the basal forebrain and brainstem reticular formation after BC; 5. The change of cerebral neurons and cholinergic neurons correlate with cognitive deficits in BC rats .

1、单摆式闭合性机械打击装置能成功建立脑震荡大鼠模型;2、脑震荡大鼠在MWM实验中出现早期空间认知行为障碍;3、脑震荡大鼠大脑皮质、背侧海马、齿状回和脑干网状结构出现程度不等的部分神经元固缩变性和不完全性坏死;4、脑震荡大鼠基底前脑、脑干网状结构ChAT活性表达有明显变化;5、脑震荡大鼠认知障碍与相关脑区神经元、胆碱能神经元的变化有关联。

After HIFU irradiation, the histopathological changes of lesions of liver and kidney mainly characterized as completely coagulative necrosis, cell debris, pyknotic nuclei.

HIFU损伤后,肝脏和肾脏治疗区的组织病理变化主要表现为细胞的完全性坏死,细胞结构完全破坏,胞浆均质状,细胞核变形、碎裂、固缩、溶解。

Results The bletilla colloid was a homogenous viscous colloid whose relative viscosity was 2324.6 mm2/s. It was easily injected through 4-F catheter and hyperattenuating under fluoroscopy, meanwhile, with good histocompatibility and hemo-compatibility, without pyrogenetic response and toxicity. In vitro, the mixture of bletilla colloid and MMC did not produce separation and suspention phenomena but released 50%of MMC at 1.8h and 100%at 3.4h. The bletilla colloid mainly embolized peripheral arteries, maintaining occlusion for 5 weeks and without formation of collateral circulation. The injuries of normal hepatic tissues were slight, without hepatic cytonecrosis.

结果 (1)白芨胶为一种均质的胶状物,有一定粘滞性,相对粘度2 324.6 mm2/s,不透X线,易经4F导管注射;(2)白芨胶具有良好的血液相容性和组织相容性,无致热原性及毒性作用;(3)白芨胶-丝裂霉素C体外混合后,无分层及悬浮现象,释放MMC 50%约需1.8小时,100%需3.4小时;(4)白芨胶主要栓塞末梢小动脉,栓塞牢靠,维持时间可达5周,不易形成侧支循环;(5)白芨胶栓塞对正常肝组织损伤轻微,未出现肝细胞坏死。

Objective:To investigate the antinociceptive effect of BTX-A and its influence on the serumal TNFin an acetic acid-induced visceral pain model in rats.

目的:探讨A型肉毒素在大鼠化学性内脏损伤中的止痛作用及对血清肿瘤坏死因子的影响。

Results:(1) The 90Y activity was higher while the contumination of 90Sr was less than 0.0031%;(2) The efficiency of 90Y-labeled antibodies was over 90%,the activity of labeled antibody maintained 82.3%;(3) Tumor size of all 90Y-antibody-treated model was significantly less than that of all 90Y-Cl3-treated model, the average survival time of the mice of the 90Y-antibody-treated group was significantly longer than that of the 90Y-Cl3-treated group;(4) In the tissue sections extensive necrosis was observed in all 90Y-antibody-treated tumor, the living tumor cells were immunohistochemically stainable with PcNA.

结果:(1)EDTA淋洗法制备90Y纯度高,其相对含量可达99.997%;(2)单克隆抗体的90Y标记率达90%以上,抗体蛋白活性保持82.3%;(3)治疗结果表明治疗组肿瘤明显小于对照组,原肿瘤的指数生长规律遭到破坏,治疗组生存期明显长于对照组;(4)组织学切片显示治疗组肿瘤有广泛坏死,PcNA免疫组化显示治疗组肿瘤细胞增殖受到明显抑制。

Objective To perform an initial study on possible molecular regulatory mechanisms of TNF-α to the permeability of strial capillary endothelial cells in guinea pig cochlea.

目的 探讨肿瘤坏死因子α对豚鼠耳蜗血管纹微血管内皮细胞通透性的影响及可能的分子调控机理。

Transluminal catheter in mind the use of a site caused by the release of radiofrequency current partial endocardial and subendocardial myocardial coagulation necrosis, thus undermining the point of origin of certain tachyarrhythmias technology intervention.

详细说明:利用电极导管在心腔内某一部位释放射频电流而导致局部心内膜及心内膜下心肌的凝固性坏死,从而破坏某些快速心律失常起源点的介入性技术。

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