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In these 46 cases ,there were 41 cases attacked with osteonecrosis of both femoral head for 3 to 6 months. There were 43 cases without any clinical symptom. The X-ray examination of these 46 cases were normal while the MRI examination were abnormal obviously ,among them ,include 7 cases with osteonecrosis of the thigh and knee and 3 cases with osteonecrosis of humeral head the caput humeus. The blood plasma lipid examination was abnormal.

在确诊的病例中,41 例3~6 个月内双侧发病;43 例患者没有明显临床症状;所有病例普通X 线均无异常表现而MRI都有明显异常表现;有7 例伴有同侧股骨干和髌骨坏死,3 例肱骨头出现坏死;血浆脂质出现不同程度的异常变化。

Tumor necrosis factor-alpha may injure vascular endothelial cells by many ways, and the injury of vascular endothelial cella can accelerate the release of tumor necrosis factor-alpha, which can injure the vascular endothelial cells again.

肿瘤坏死因子α可通过多种途径损伤血管内皮细胞,血管内皮细胞的损伤又促使肿瘤坏死因子α的释放,再次损伤血管内皮细胞,两者互为因果,形成恶性循环。

The crutching and walking function of the leg reconstructed at last Conclusion When all the necrotic intermuscular vessels and muscles except caput mediale of gastrocnemius were removed, the necmsis may be delayed by means of reticular collateral circulation among skin, deep and superficial fascia and tibia of the injured limb. However, the blood supply is very little, the severe ischemia wound and ischemia pain can't be healed.

除腓肠肌内侧头以外全小腿肌肉、肌间血管均坏死被切除时,小腿皮肤、深浅筋膜组织、腓肠肌内侧头肌瓣与胫骨内血供系统在踝以下所构成的网状侧支循环能为患足提供微量血供,延缓足的坏死,但仅凭这一微量血供无法治愈广泛贫血创面和顽固性肢体缺血痛。

Results 2 ClAdo and 2 CldAdo had different cytotoxicities on the cells, while 2' dAdo had no cytotoxicity on the cells. 2 CldAdo blocked the cell growth at the phase of S and G2/M, while 2 ClAdo at the phase of G0/G1. 2 CldAdo mainly induced cell necrosis, while 2 ClAdo induced both cell necrosis and apoptosis. Down regulated Bcl 2 expression and up regulated p53 and Bax expression were associated with 2 ClAdo, while 2 CldAdo down regulated Bcl 2 expression and up regulated mildly p53 expression without any effect on Bax expression.

结果 2 ClAdo、2 CldAdo对所研究的细胞均有程度不等的毒性;2' dAdo对各细胞生长、增殖均无明显抑制(c=100 μmol/L即30 μg/mL内);2 CldAdo明显阻断细胞于S、G2/M期,2 ClAdo阻断细胞于G0/G1期;2 CldAdo 致细胞坏死为主,2 ClAdo 既致细胞坏死又诱导凋亡;2 ClAdo 下调Bcl 2,上调P53、Bax蛋白表达;2 CldAdo小幅上调P53、小幅下调Bcl 2,不影响Bax蛋白表达。

Results Cvb-D obviously lightened isoprenaline-induced myocardial pathological changes such as turbulence of myocardial fiber, plasmolysis of necrotic cell, inflammatory cell infiltration of necrotic interstitial region. Cvb-D remarkably inhibited myocardium cell apoptosis of myocardial ischemia rats caused by isoprenaline.

结果 Cvb-D可显著减轻Iso诱发的心肌缺血致心肌肌纤维排列紊乱,坏死细胞胞泉溶解,坏死间质区炎性细胞浸润等病理改变;Cvb-D可显著抑制Iso诱发的心肌缺血性模型大鼠心肌细胞凋亡。

Activation of NF-κB(p65) with evident nuclear translocation was found in neonatal rat NEC model. The pathological lesions indicated that intestinal tissue necrosis in varying degrees in group C and D, which were 2-4 points, but obviously lessened in group E, which were 0-2 points. Conclusions Intestinal inflammation is ameliorated after the ITF is injected hypodermically.

结果 C、D组组织中NF-κB(p65)阳性表达较A、B及E组显著升高P(下标 a.01,E组与A、B组比较也有升高P(下标 a.01,且随NF-κB(p65)的激活有明显的核转移;病理切片示C、D组HE染色见肠壁损伤轻重不一,可见全肠黏膜绒毛坏死,病理评分2~4分;E组轻度肠上皮细胞脱落,顶端绒毛坏死,肠组织病理评分0~2分。

Objective To establish an effective technique in reservation and function reconstruction of a leg, in which all the muscles except gastrocnemius necrosed induced by the delayed necrosis of all the intermuscular vessels, the foot was linked only by skin, fascia and tibia, Methods The leg was linked with foot only by the skin, fascia, caput mediale of gastrocnemius and tibia when all the muscles, intermuscular vessels and fibula were removed.

目的 探索迟发性小腿全长肌间血管全部坏死而导致除腓肠肌内侧头以外小腿肌肉全部坏死,仅以皮肤、筋膜、胫骨连足的情况下肢体保留和功能重建的方法。

Results24 and 48 hours after SE,we saw morphologically necrotic neurons in nucleus amygdalae,as well as DNA ladder.Neither apoptotic nor necrotic neurons were seen in rats injected with saline.

结果在第24小时和第48小时两时点,SE 大鼠杏仁核神经元出现了形态学上的坏死和梯状DNA电泳带,对照组未见到坏死及凋亡细胞。

Results 1~19years follow-up survey,among26cases,25cases of its function of coxae arts were good,had it appeared case had it union6monthes after operation.

结果 术后1~9年的随访26例中25例骨折愈合良好,功能恢复,皆无并发股骨头坏死或其他并发症,仅1例术后6个月尚未愈合,但无坏死。

In combination group, hepatocyte showed degeneration or necrosis at different degrees; villi of small intestine necrosed and shed, accompanied by great amount of lymphocyte infiltration (Grade Ⅲ-V in pathological grading).

混合移植组肝细胞呈不同程度的变性或坏死,小肠绒毛坏死脱落,黏膜下层大量淋巴细胞浸润,病理分级为Ⅲ-Ⅴ级。

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