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Morphological and flourescent changes were assessed using confocal microscopy in whole-mount organ of Corti preparations. Results (1) After the animals were exposed to broadband noise at 122 dB SPL in 4 h/day for 2 days, both apoptosis and necrosis appeared in OHCs. The single strand DNA in apoptotic OHCs were observed both in guinea pigs and mice.(2) In normal OHCs, EndoG was distributed outside of nuclei. EndoG translocated from outside to inside of the nuclei in both apoptotic and necrotic OHCs following noise exposure.(3) The MNNG cochlear perfusion and noise exposure both caused the transloctation of AIF from the mitochondria to the nuclei. The translocation of AIF took place in both apoptotic and necrotic OHCs.

结果 (1)暴露于120 dB SPL的白噪声环境中每天4小时,连续2天后引起豚鼠和小鼠耳蜗外毛细胞凋亡时,其细胞核内产生ssDNA,而在正常细胞内没有三ssDNA;(2)在正常情况下,EndoG分布于耳蜗毛细胞的细胞核外,在暴露于上述噪声后发生凋亡和坏死的豚鼠耳蜗外毛细胞中,EndoG从细胞核外转移到细胞核内,细胞核中的EndoG显著增加;(3)豚鼠耳蜗外淋巴灌流烷化剂MNNG后发生耳蜗外毛细胞凋亡和坏死,在凋亡和坏死的耳蜗外毛细胞中,AIF自线粒体转移到细胞核,其变化与噪声损伤引起耳蜗外毛细胞凋亡和坏死时一致。

Pathology and ultrastructure detection revealed cell necrosis and collapse, sever nuclear damage was observed in the death cells. The early characteristics of necrosis such as margination of heterochromatin was also found in some tumor cells. Besides, well differentiated tumor cells, degenerative tumor cells and some lymphocytes were seen.

直形针给药组肿瘤组织早期表现为大片的组织坏死,晚期表现为存活区域的增加,坏死区域与存活区域界限分明,两者间多有移行带;弧形针分段扇形注药者早期、晚期组织均表现为大片坏死,肿瘤间质内可见淋巴细胞浸润和纤维结缔组织增生;各时间段的检测标本中都可见一定数量的凋亡细胞,但比例远远小于坏死的肿瘤细胞。

BACKGROUND: According to traditional theory of the recovery after acutetubular necrosis, reconstruction of renal tubule is dependent on residual epithelialcells next to the necrosis region. Undergoing the process of dedifferentiation,proliferation and redifferentiation, these cells can reestablish the injured tubule and itsfunction.

背景:传统的急性肾小管坏死修复理论认为,肾小管的重建依赖于坏死区周围存活的肾小管上皮细胞,这些细胞经过去分化、增殖和分化成熟等过程修复坏死的肾小管,重建其组织结构和功能。

Adductor tenotomy,closed reduction and frog type plaster immobilization process is a effective way to treat children with DDH between 6~36 months old.

内收肌切断、手法闭合复位、改良蛙式石膏固定方法对6~36个月发育性髋脱位患者是一种有效的治疗方法,能很好的降低股骨头缺血性坏死的发生率,复位前髋臼指数值的大小与股骨头缺血性坏死的发生关系不大,但大于2 cm的高度脱位是并发股骨头缺血性坏死的重要因素之一。

N perifocal tissue intracerebral hemorrhage there were rarefaction neuron,cell spaces augmentation,cell diminution,distinct demarcation of cell membrane and surrounding,and we discovered a lot of degeneration and necrosis nerve cells,cell body collapsed,pycnosis anachromasis,nucleoli disappeared. In EPO group we discovered that center area of hemorrhage shinked,nerve cells of degeneration and necrosis decreased in perifocal tissue,majority cells morphous were normal and pathological changes were light.

CH对照组在术后皮层出血中心无神经元,仅见少量胶质细胞,细胞间质空泡样改变;出血边缘区神经元稀疏,细胞间隙增大,细胞缩小,胞膜与周围分界清楚,并可见大量变性及坏死的神经细胞,表现为胞体皱缩,核固缩深染,核仁消失。rhEPO治疗组出血中心区变小,边缘区神经细胞变性坏死减少,多数存活细胞形态相对正常,病变较轻。

Objective To evaluate the therapeutic effect of vascular endothelial growth factor and tumor necrosis factor receptor on avascular necrosis of the femoral head in rabbits.

目的 探讨应用血管内皮细胞生长因子与肿瘤坏死因子受体联合治疗股骨头坏死的治疗效果。

Caseous necrosis is really just a combination of coagulative and liquefactive necrosis that is most characteristic of granulomatous inflammation.

呈黄褐色到白色外观,是凝固性坏死和液化性坏死的复合性坏死,属于炎症肉芽肿的特征性变化。

Debris necrosis of lymph node is not the specific changes of KD. In the tuberculosis of lymph node,① debris necrosis is obvious, but it tends to be caseous nercrosis;② histiocytes, macrophages and foam cells are hyperplasia in the necrotic area or lymph sinus, moreover, epithelioid cells can be found and they tend to be form granuloma;③ numbers of neutrophils infiltrate in the necrotic area;④ the etiologic assay of acid fast bacterium tuberculosis bacterium is positive;⑤ typical clinical manifestation is insufficient.

淋巴结碎屑性坏死并非KD特有病变,诊断KD需先除外有明显碎屑性坏死的淋巴结结核病,后者主要表现:①碎屑性坏死虽明显,但趋于干酪样坏死;②坏死区内或同时在淋巴窦内,组织细胞、巨噬细胞和泡沫细胞增生,并演变为上皮样细胞和趋于肉芽肿形成;③坏死灶内、外可有数量不等的中性粒细胞浸润;④抗酸杆菌/结核杆菌病原学检测阳性;⑤缺乏KD的典型临床过程。

Of all these femoral heads,21 presented cystiform change,fragmentation and deformation of femoral head were found in 15,15 femoral heads associated with joint effusion.Conclusion:C...

CT在发现股骨头缺血性坏死的早期病变以及确定病变范围等方面优于普通X线,CT在早期诊治股骨头缺血性坏死中具有重要价值。

At present, there are many approaches to make a quantitative analysis on head necrosis, many of which take the index of head necrosis range and Proportion of Necrosis area as the most typical guide lines for quantitative diagnosis and Collapse forecast.

目前,通过MRI对股骨头坏死定量分析的方法很多,以坏死范围指数、坏死面积比例的大小为股骨头坏死定量诊断及塌陷预测的最具代表性的指标。结论:MRI可对股骨头坏死灶的大小做出较为准确的判断,可对股骨头坏死的诊治给予重要的指导作用。

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