坏死后的

Morphological and flourescent changes were assessed using confocal microscopy in whole-mount organ of Corti preparations. Results (1) After the animals were exposed to broadband noise at 122 dB SPL in 4 h/day for 2 days, both apoptosis and necrosis appeared in OHCs. The single strand DNA in apoptotic OHCs were observed both in guinea pigs and mice.(2) In normal OHCs, EndoG was distributed outside of nuclei. EndoG translocated from outside to inside of the nuclei in both apoptotic and necrotic OHCs following noise exposure.(3) The MNNG cochlear perfusion and noise exposure both caused the transloctation of AIF from the mitochondria to the nuclei. The translocation of AIF took place in both apoptotic and necrotic OHCs.

结果 (1)暴露于120 dB SPL的白噪声环境中每天4小时，连续2天后引起豚鼠和小鼠耳蜗外毛细胞凋亡时，其细胞核内产生ssDNA，而在正常细胞内没有三ssDNA；（2）在正常情况下，EndoG分布于耳蜗毛细胞的细胞核外，在暴露于上述噪声后发生凋亡和坏死的豚鼠耳蜗外毛细胞中，EndoG从细胞核外转移到细胞核内，细胞核中的EndoG显著增加；（3）豚鼠耳蜗外淋巴灌流烷化剂MNNG后发生耳蜗外毛细胞凋亡和坏死，在凋亡和坏死的耳蜗外毛细胞中，AIF自线粒体转移到细胞核，其变化与噪声损伤引起耳蜗外毛细胞凋亡和坏死时一致。

The researching result of this field is conflicting in these years. Some researchers consider it as apoptosis, while some necropsy results don\'t support the hypothesis. Our study is to investigate the protein expression and biochemistry changes under oxidative stress to determine if apoptosis happens.

多巴胺能神经元的死亡是凋亡还是坏死目前的研究结果不一，有许多的研究说明在氧化应激的条件下，细胞的死亡是凋亡，而部分尸检结果不支持凋亡的学说，本实验拟从蛋白表达及生化学方面观察氧化应激后细胞有无凋亡的发生。

In treatment group, there was no progressive necrosis in stasis zone, and at 24 h post injury, capillary dilation, cell edema and inflammatory infiltration were lessened significantly. In control group, 2 wounds had progressive necrosis (accounted for 10% of the total). Cell edema, inflammatory infiltration and capillary thrombosis were serious, Until 72 hr post injury, cell edema did not subside and necrosis of the dermis worsened. 2. Pathological assessment of the stasis zone tissue: As compared with that in control group, in treatment group the dermis structure in stasis zone was intact and the collagenous fiber bundle was normal.

结果：①创面细胞形态学改变：伤后8h毛细血管扩张、细胞水肿，炎性浸润最明显；治疗组中央淤滞区无进行性坏死，伤后24h后毛细血管扩张、细胞水肿、炎性浸润减轻；对照组2个创面呈进行性坏死（占10%），中央淤滞区细胞水肿、炎性浸润明显，毛细血管血栓形成，伤后72h水肿仍明显，真皮坏死加重；②淤滞区组织病理学评分：治疗组与对照组相比，治疗侧淤滞区的表皮结构相对完整、胶原纤维束相对正常，粒细胞浸润小于5个/400倍视野。

Day puppies were inoculated by abdominal cavity and nasal cavity with CDV,canine distemper patho-sample of duplicating meet with success and through differentdrug of treatment, specific antibody, dexamethasone, causing death by letting. Theresults of pathohistology observation on 14 PID: Control group, the hearts showedcardiac muscle hemorrhage and necrosis, the livers showed a large area of hepatictissue hyperemia, hemorrhage and necrosis, the spleens showed the quantity oflymphocyte grow downwards, the blood vessels of lung congested, congestion andhaemorrhage were serous fluid exudation, the kidneys showed heavy haemorrhageand hyperemia, the cerebrum showed the number of microglial cells of cerebrumincreased.

通过特异性抗体和地塞米松、特异性抗体、地塞米松三种不同的方法治疗后，放血致死，取材作病理切片，观察各组病理组织学变化，结果为：感染后14d阳性对照组的心脏表现为心肌出血、坏死；肝脏表现为肝组织大面积充血、出血坏死；脾脏表现淋巴细胞数量大量减少；肺脏表现为肺泡结构破坏，有坏死灶；肾脏表现为弥漫性的充血出血；大脑表现为胶质细胞增多。

(1) The 2% glutaraldehyole pulpotomy has the function of killing bacteria and could cure deep caries and early pulpitis;(2) The curative effects of six months after operation is better than that of three months and of upper jaw is better than that of lower jaw by using 2% glutaraldehyole pulpotomy;(3) The prognosis of 2% glutaraldehyole pulpotomy depends on selecting indication and the patients cooperation in the course of operation;(4) It must be early performed with the root canal therapy that the cases of further developing apicitis, the absorption of root apiex is over 1/3, the pulp necrosis and periapical disease.

(1) 2%戊二醛活髓切断术具有杀菌的功能，对于深龋及早期牙髓炎可以治愈；(2) 2%戊二醛活髓切断术治疗乳磨牙牙髓炎六个月后的疗效明显好于三个月的疗效，上颌组疗效明显好于下颌组；(3) 2%戊二醛活髓切断术的预后取决于适应证的选择及治疗过程中患儿的配合程度；(4)对于进一步发展为根尖炎的病例及根尖吸收超过1/3、牙髓坏死和根尖周有病变者，应及早行根管治疗术。

Fibroplastic proliferation was observed at 14th days and later.

肝脏碘油栓塞HIFU损伤后即刻损伤组织表现为肝细胞结构破坏，肝细胞核固缩。3天后坏死区与正常组织分界清楚，坏死区细胞完全破坏。14天出现明显增生的纤维结缔组织，包绕坏死组织。

Blinded biopsies were evaluated by a histopathologist and scored according to Knodells histology activity index. Results 53.5%(54/101), 51.5%(52/101) and 31.7%(32/101) patients had a reduction of their total hepatic HAI score, necroinflammation and fibrosis scores by ≥2 points or 1 points at the end of one year of lamivudine therapy, compared with their pretreatment values, respectively.

结果 治疗后53.5%（54/101）患者肝组织学改善（治疗后HAI积分下降≥2），HAI积分由治疗前的8.0±4.7下降至治疗后5.2±3.3（t＝7.358，P.01）；其中51.5%（52/101）患者坏死炎症程度改善(治疗后积分下降≥2)，坏死炎症积分由5.9±3.8下降至3.6±2.5；31.7%（32/101）患者纤维化程度改善（治疗后积分下降≥1），纤维化积分由2.1±1.2下降至1.6±1.2（t＝3.827，P.01。

There were no statistically differences between the 8th~ 14thday, the 15th - 21th day post-BC and the control group. During the rt~24tkday post-BC , pycnosis degeneration or necrosis neurons of the locus cerebral cortex, dorsal hippocampus, dentate fornix were significantly increased, then decreased gradually, but recovered to normal by the 24thday after BC, and especially in parietal cortex and piriform cortex the necrosis neurons were significantly increased than temporal cortex , and there were no statistically difference berween the left and the right side. Pycnosis degeneration or necrosis neurons in the brainstem reticular formation were markedly increased in the 4thday after BC, and there were no statistically difference among the other groups and the control group.

与对照组相比，BC后在大脑皮质、背侧海马和齿状回部位，固缩变性和不完全坏死细胞数先显著增加(P＜0.05)，然后逐渐减少，至24d基本恢复正常；顶叶、梨状皮质比颞叶皮质变性坏死细胞多，差异有高度显著性(P＜0.01)；大脑左侧比右侧变性坏死细胞稍少但差异无显著性；在BC后4d，脑桥核、斜方体核平面的脑干网状结构中固缩变性和不完全坏死细胞数明显增多(P＜0.05)，其它组间无显著性差异。

Underlight microscope,we can find edema and few focal necrosis of right nerve cells of neonate rats after 2 to 6 hours of hypoxic-ischemia. We can find clear necrosis in brain tissue after 72 hours of hypoxic-ischemia.

HE染色缺血缺氧后2-6h右侧脑神经细胞水肿及少量局灶性坏死，缺血缺氧后72h右侧脑组织中可见界限清楚的坏死灶。

METHODS: 40 cases were classified stage IV with lumen obstruction after they failed all other treatment regimens. PDT was performed witn 630nm light delivered through cylinder diffusing tip quartz fibers passed through the biopsy channel of a flexible endoscope 48h after intravenous injection of the photosensitizer photofrin. PDT endoscopy was repeated and necrotic tissue was mechanically removed and, if necessary, that site or other new sites were treated after 48 hours. Two days after this another endoscopy was performed and the necrotic tissue was mechanically removed. Endoscopy was repeated one month after PDT and periodically thereafter as needed to re-treat symptomatic residual tumor.

40例肿瘤患者均属于IV期，所有患者都经过化疗、放疗或其他方法治疗无法解除腔道梗阻或不完全梗阻，部分完全梗阻患者结合其他治疗手段解除梗阻，光敏剂为photofrin，按2mg/kg体重静脉滴注，48小时后经内镜导入光导纤维给以630nm（DIOMED半导体激光治疗机）的激光照射，2天后经内镜清除坏死组织并对原有病灶和新发现病灶给以复照，之后根据具体情况给患者的病灶部位清除坏死组织。

She gently rebuff ed him, but agreed that they could be friends

她婉言拒绝了，但同意作为朋友相处。

If in the penal farm, you were sure to be criticized.

要是在劳改农场，你等着挨绳子吧！