均化作用

Phosphate porous starch and PVA were cross linked by methenamine and boric acid Crystal area was serious destroyed by esterification and cross linked. 6 Biodegradation experiment was carried out with soil-burying method.

5红外光谱和X-射线衍射的结构分析表明：在改性淀粉的羟基上引入了磷酰基团，并未破坏原淀粉的基本化学结构；交联剂在改性淀粉和PVA之间形成了C-O-C化学交联键；酯化和交联反应均有较强的淀粉晶区破坏作用。

After treated with recombinant mouse RAGE/Fc chimera/HMGB1, anti-RAGE antibody/HMGB1, HMGB1 or nonimmune rabbit igG, the phagocytosis was determined by the neutral red dye uptake, the cytotoxicity to L1210 cells was measured with MTT assay, the chemotaxis was determined by use of Costar Transwell cell culture chamber inserts, and the expression of I-A^k MHC class Ⅱ antigen on macrophages was detected by flow cytometry.

结果100μg／L的HMGB1作用于巨噬细胞48h后，巨噬细胞表面受体RAGE表达明显上调（P〈0.01）；HMGB1组巨噬细胞吞噬功能、杀伤活性、趋化活性及I-A^k抗原表达均显著高于对照组、HMGB1＋抗RAGE组与HMGB1＋rmRAGE／Fc组（P〈0.01）。

Protease treatment of the plasma membranes could abolish the binding but NaIO_4 and glycosidase could not, indicating that nsLTP144 bound to plasma membranes protein without carbohydrate moiety. Using the homobifunctional cross-linking regent bissuberate (BS~3) and rice plasma membranes incubated with ~(125)I-Trx-nsLTP144, we identified, after SDS-polyacrylamide gel electrophoresis and autoradiography, a putative protein receptor on the rice plasma membranes with the molecular mass around 60 kDa. NsLTP144 can not trigger extracelluar alkalization in arabidopsis, but can abolish the extracellular alkalization effect of phytopathogen elicitor cryptogein, suggesting that cryptogein and nsLTP144 may bind to the same membrane protein. In vitro pull-down assay showed that nsLTP144 interacted with OsCaM1, a possible extracellular calmodulin, implying that nsLTP144 and OsCaM1 could function in the same signal transduction pathway. These results shed light on revealing the roles of nsLTP in vivo and make it promising to finally characterize the plasma membranes receptor of nsLTP.

发现~(125)I-Trx-nsLTP144、~(125)I-Trx-nsLTP110与水稻细胞质膜均具有特异性结合，而且结合是饱和性的、可被竞争的，符合配体-受体结合的典型特征，同时用于对照实验的蛋白质~(125)I-Thioredoxin没有此特性，表明水稻细胞质膜上存在nsLTP的受体；利用可氧化糖基的NaIO_4和水解糖基的N\'-糖苷酶F处理水稻细胞质膜，再进行结合实验，结合活性几乎不受影响；而利用胰蛋白酶处理细胞膜则使得结合能力几乎完全丧失，表明其受体为没有经过糖基化修饰的蛋白质；利用交联剂BS~3交联配体一受体后，再进行SDS-PAGE分离和放射自显影，结果显示水稻细胞质膜上的nsLTP受体中有一个60kDa的蛋白质可以与nsLTP144发生特异性的结合，可能是其受体；细胞外碱化实验表明，nsLTP144不能促使拟南芥原生质体细胞培养液的细胞外碱化反应，却能猝灭来自植物病原菌的激发子Cryptogein刺激拟南芥原生质体产生的细胞外碱化反应，表明nsLTP和Cryptogein结合细胞膜上相同的位点，保护了植物细胞免受Cryptogein导致的细胞程序性死亡，并诱导系统获得性抗性的产生；体外Pull-down实验表明，nsLTP144和水稻的OsCaM1具有相互作用，暗示了nsLTP144和OsCaM1可能同在一个信号通路上起作用。

NCPs play a important role in differentiation of osteoblast, formation, calcification, and resorption of bone matrix.

NCPs在成骨细胞的分化、骨基质的形成、矿化和吸收方面均起着重要的作用。

Objective:The aims of the present study were to determine the expression of transformation growth factor β 1 (TGF β 1) mRNA and TGF β 1 protein in the peripheral blood and its relation to serum levels of procollagen type Ⅲ N terminal peptide in the patients with cirrhosis.

转化生长因子-β1(TGF-β1)在一些体外和体内的研究中均显示能刺激胶原和细胞外基质的合成，同时又可通过抑制ECM降解以加强纤维的发生，在肝纤维化中起重要作用。

It was shown from the results that emulsifier TP-Ⅴ which was prepared by PEG 4000 reacted with TME, in the molar ratio of TME to PEG 2:1, at about 110℃ for 1 h, catalyzed by boron trifluoride diethyl etherate, has a very good emulsifying impact for TME. Particle size distribution of the emulsion was homo-geneous and viscosity of the emulsion was small.

实验结果表明，以M相对适中的PEG4000与TME按物质的量比2： 1、在催化剂三氟化硼乙醚作用下、110℃左右反应1h合成的乳化剂TP-Ⅴ，对萜烯基环氧树脂具有很好的乳化效果，制备的乳液粒子粒径均一度较高，乳液表观黏度较小。

As noted above,membrane-stabilizers unexpectedly improved the heart function andprevented ER stress both in vivo and in cultured cells.We know that the membranestability depends on the sodium homeostasis in fact.To investigate whether ER stress isassociated with sodium channel action,which determins the membrane stability,wepretreated H9c2(2-1) cells with veratridine,a sodium channel activator.

上面的研究发现膜稳定剂在体内体外均抑制了内质网应激，并改善了心脏功能，而膜稳定作用实际上是维持细胞钠离子稳态的结果，为了研究内质网应激反应与钠离子活动的关系，我们用一种钠通道激活剂藜芦定刺激H9c2(2-1)细胞，30分钟时GRP78表达增加；24小时时PERK磷酸化和CHOP蛋白表达显著增加，说明钠离子通道过度激活诱发了内质网应激反应。

Objective To study the relationship of endangium proliferation and the expression of metalloproteinases and tissue inhibitors of metalloproteinases after angioplasty of iliac artery in rabbits to investigate the probable mechanism of composite Danshen pill in prevention and treatment of restenosisMethods 30 white male rabbits of Japan （the average body weight was 25～30 kg）were randomly divided into 3 groups:normal control group,model group (intima destroyed by balloon and given hypercholesterol diet),CDP group (intima destroyed by balloon and given hypercholesterol diet plus drug CDP 150 mg/d),10 ones each groupResults The results of iliac artery angiogram and the analysis of pathology:there were lumens stenosis,thinner intima,smaller intima area,in CDP group compared with those in model group,and ratio of intima and tunica media thickness and area among each group (P＜001)Immunohistochemistry analysis:the MMP2,MMP9,TIMP1,TIMP2 in model group significantly increased than those in control group (P＜001)The CDP group had lower MMP2 and MMP9 expression,higher TIMP1 and TIMP2 expression,and increased MMP2/TIMP1,MMP9/TIMP2 than model group (P＜001)The thickening of vascular neointima and stenosis degree of vascular lumen were relevant to MMP2 and MMP9 (r=0896,P＜001)Conclusions MMP and TIMP play the very important role in the restenosis process of arteryCDP could inhibit the thickness of vascular neointima after balloon injury,the probable mechanism of which may be inhibiting collagen formation,smooth muscle immigration and decreasing hyperplasia of intima by interfering expression of MMPs and TIMPs

目的 研究兔髂动脉成形术后血管内膜增生和基质金属蛋白酶及其抑制物表达之间的关系，探讨复方丹参滴丸预防再狭窄的可能机制。方法健康成年二级雄性日本大耳白兔30只，平均体重25～30 kg。随机分为3组：正常对照组10只，模型组10只（球囊内膜剥脱加高胆固醇饮食），治疗组10只（球囊内膜剥脱加高胆固醇饮食以及复方丹参滴丸150 mg/d）。结果兔髂动脉造影、血管病理图像分析检测结果：①复方丹参滴丸组较模型组血管造影示管腔直径狭窄、内膜厚度减少、内膜面积减少、内膜厚度和中膜厚度比、面积比，各组之间有显著性差异(P＜001)。②免疫组化分析：模型组MMP2、MMP9、TIMP1、TIMP2表达均高于对照组（P＜001）；复方丹参滴丸组MMP2、MMP9的表达低于模型组，而TIMP1、TIMP2的表达高于模型组；TIMP1/MMP2、TIMP2/MMP9明显增加，差异有显著性（P＜001）。③内膜的增生以及管腔的狭窄程度与MMP2、MMP9有很好的相关性(r=0896，P＜001)。结论 MMP和TIMP在再狭窄形成中起重要作用；复方丹参滴丸能够明显抑制血管损伤后的内膜增生，可能的机制是通过影响金属蛋白酶MMP2、MMP9及其抑制物TIMP1、TIMP2的表达从而抑制胶原的生成、平滑肌的迁移、增生，而减少内膜的增生。

The gold deposit is closely associated with the feldspathic quartz gray-wacke of the Zhuanqiangwan Formation of the Furongxi Group and the pebble-bearing feldspathic quartz gray-wacke of the Sinian Changtan Formation.

芙蓉溪群砖墙湾组长石石英杂砂岩和震旦系长滩组含砾长石石英杂砂岩均具明显的控金作用。砂岩层往往大面积发生矿化蚀变，矿体严格受砂岩层控制。

2The choosen 16mg/ml percolation filtration of Hirudo and 0.02 ug/ml PDGF were used to incubate RPE cells for 15 minutes with three different modes.

结果(1)0.02μg/mlPDGF促RPE细胞增殖作用最佳(p.05)；(2)16mg/ml水蛭渗滤液在3种加药方式下均能不同程度抑制细胞内PTK活性，降低转录因子STAT3的磷酸化水平。

According to the clear water experiment, aeration performance of the new equipment is good with high total oxygen transfer coefficient and oxygen utilization ratio.

曝气设备的动力效率在叶轮转速为120rpm～150rpm时取得最大值，此时氧利用率和充氧能力也具有较高值。

The environmental stability of that world - including its crushing pressures and icy darkness - means that some of its most famous inhabitants have survived for eons as evolutionary throwbacks, their bodies undergoing little change.

稳定的海底环境─包括能把人压扁的压力和冰冷的黑暗─意谓海底某些最知名的栖居生物已以演化返祖的样态活了万世，形体几无变化。