在改变

The p53 gene structural abnormality and mdm2 protein overexpression might be two factors causing p53 protein overexpresion in NPC. The function of p53 proteins produced by various structural anormality of p53 gene might be different in activating MDM2. The overexpression of p53 or mdm2 protein, particularly both cooperation, might play an important role during NPC genesis.Key words: Nasopharyngeal neoplasms; p53 gene; p53 protein; mdm2 protein

p53基因结构改变和mdm2蛋白过度表达是影响NPCp53蛋白过度表达的两个因素；不同类型p53基因结构改变所产生的p53蛋白激活MDM2的功能并不相同；p53和mdm2蛋白过度表达，尤其两蛋白协同作用，可能在NPC发生中起重要作用。

De Assis, who presented the work at the American Association for Cancer Research meeting in Washington DC, says a fatty diet may cause "epigenetic" DNA modifications that can be passed on to future generations.

De Assis在华盛顿特区举行的美国癌症研究协会会议上提交了研究论文。他说高脂肪饮食可能导致了&后成的&DNA改变，这种改变可以传递给未来的几代实验鼠。

It shows that it is possible to increase the start oscillation length by tailoring magnetic field's amplitude and its period without changing the synchronous condition of the fundamental wave;in the meantime, when there are two or more azimuthally asymmetric space harmonics in the high power broad-band helix TWT, the influences of the Pierce's gain parameter, space charge parameter, and loss parameter on the start oscillation length and real starting asynchronous velocity parameter are also analyzed.

研究结果表明：改变聚焦磁场的幅值或周期来增加起振长度是可能的，而且不会改变基波的互作用条件。与此同时，对起振长度、初始非同步速度参量随皮尔斯增益参量、空间电荷参量、损耗参量等的变化，以及在超宽带行波管中当存在两个或多个角向非对称空间谐波时，起振长度、初始非同步速度参量随周期永久聚焦磁场的变化进行了研究。

Udana is the least dense of the pranas ,then comes prana ,samana ,and apana .vyana ,which flows over the whole body ,has a density which is the average of all the others .the different colors of the pranic or bioplasmic clouds are due to the emission of photons when electrons change their energy levels from higher to lower frequencies .

按能量的密度从小到大，依次是UDANA，PRANA ，SAMANA和APANA。在全身密布的是密度居中的VYANA。当电荷改变了他们的能量从高到低的水平的时候，他们的颜色、以及存在的空间，向外扩散的方式也随之改变。

As a result, to chang the current density, pH have huge influence on cathodal overvoltage, to alter electrolyte concentration have little influence on cathodal overvoltage, and to chang the overvoltage will change the dimension of the powder directly.

结果表明：电流密度、pH值的改变对阴极过电位影响显著，电解液浓度的改变对阴极过电位无显著影响；而过电位的变化直接引起粉体粒径的变化；在阴极过电位高的条件下。

Results The two groups were all observed and followed-up,the treatment group on therapeutic effect,the mucosa change under colonoscope and bowel mucosa pathohistology change were higher than that of the control group（the former efficiency were 93.18%、95.45%、95.45%）,and adverse reaction was lower than that of the control group.

结果 治疗组44例、对照组39例完成观察和随访。治疗组在临床疗效、结肠镜下黏膜改变、肠黏膜病理组织学改变方面均优于对照组（前者有效率分别为93.18%、95.45%、95.45%）。不良反应低于对照组。

On the bases of these work, in order to reveal the physical mechanism of this recurrence behavior, the coseismic coulomb stress changes generated by fault interaction is calculated by inducting rock and fault mechanics, and their triggering and delaying influences on seismic potential of active fault are analyzed.

在此基础上，为了从机理上揭示大陆板内地区地震复发行为的物理机制，引入力学方法，研究了断裂间的相互作用及其产生的同震库仑应力改变，并对同震库仑应力改变对活动断裂地震潜势的影响进行了分析和讨论。

Camshaftless valve actuation includes electromagnetic,electrohydraulic,electropneumatic and electromechanical types.it could vary valve timing agilely,simplify the engine's structure,deactivate some of the engine's cylinders selectively and vary the effective compression ratio flexibly to adapt different fuels.So it could offer more advantages than general variable valve timing.

阐述了在发动机上以电磁、电液、电气或其他方式驱动气门，实现无凸轮轴气门驱动，可以灵活改变气门正时，简化发动机结构，能有选择地闭缸，灵活改变发动机有效压缩比以适应多种燃料要求，使发动机获得比采用一般可变气门驱动更多的好处。

Expression of nNOS mRNA, eNOS mRNA and iNOS mRNA in the E 20 cerebral cortex: There were no obvious changes of expression of nNOS mRNA in ETU-injected and control groups. Expression of eNOS mRNA increased significantly in cerebral cortex of the encephalocoele group, And there were no obvious changes of expression of eNOS mRNA in cerebral cortex of the control group and the other ETU-injection groups.

六、不同组E20胎鼠大脑皮质中nNOS mRNA、eNOS mRNA和iNOS mRNA的表达 1、实时定量PCR检测发现对照组、给药无畸形组、脊柱裂组和脑膨出组E20胎鼠大脑皮质中nNOS mRNA表达无明显改变； 2、给药无畸形组、脊柱裂组和对照组胎鼠大脑皮质中eNOSmRNA表达无明显改变，而脑膨出组胎鼠大脑皮质中eNOS mRNA表达明显增多； 3、在各组未检测到iNOSmRNA表达。

Objective To examine the value of Edaravone in the treatment of vascular dementia through ethologic and pathologic changes induced by chronic cerebral ischemiaMethods Wistar rats were randomly divided into sham operated group,model group,edaravone group and duxil groupThe chronic cerebral hypoperfusion models were made by permanent bilateral occlusion of both common carotid arteriesThe memory ability and ultramicrostructure of brain tissue were observedResults The escape latencies in model group were more significantly prolonged than that in the other groups (P＜005)But there was no significant difference between edaravone and duxil groupAnd pathologic changes observed by electron microscope in nerve cell of edaravone group and duxil group and model group were fairly light than that in sham operated groupEdaravone group had increased mitochondrium and frontal membranous synaptic vesicle and more productive metabolic activityConclusions Edaravone can lessen injures of hippocampal neurons loss to improve the spatial learning and memory abilitiesAnd it is proved further that edaravone can treat VD

目的 观察依达拉奉对慢性缺血致血管性痴呆大鼠行为学及形态学的影响，探讨依达拉奉在治疗VD中的应用价值。方法实验分假手术组、模型组及都可喜对照组及依达拉奉治疗组，应用双侧颈总动脉结扎方法制备慢性脑缺血大鼠痴呆模型，观察各组大鼠的记忆功能及脑组织超微结构改变。结果缺血组水迷宫表现同对照组、都可喜组及依达拉奉组相比有显著差异(P＜005)，依达拉奉组与都可喜组相比未见显著差异。同时电镜观察结果也发现依达拉奉组及都可喜组与模型组及假手术组相比神经细胞病理改变较轻，且依达拉奉组线粒体及前膜突触小泡增多，代谢活动较都可喜组旺盛。结论依达拉奉可能通过减轻海马神经元的损伤来改善慢性脑缺血大鼠空间学习记忆障碍，证明依达拉奉对慢性缺血致VD大鼠具有治疗作用。

And Pharaoh spoke to Joseph, saying, Your father and your brothers have come to you.

47：5 法老对约瑟说，你父亲和你弟兄们到你这里来了。

Additionally, the approximate flattening of surface strip using lines linking midpoints on perpendicular lines between geodesic curves and the unconditional extreme value method are discussed.

提出了用测地线方程、曲面上两点间短程线来计算膜结构曲面测地线的方法，同时，采用测地线间垂线的中点连线和用无约束极值法进行空间条状曲面近似展开的分析。