在

DCs acquired by our reformed methods express both CD83 and CD 14 molecules highly, and have a higher density than other domestic reports. The higher TNF in DCs culture medium of HC patient suggests DCs in patient still have antigen presenting ability and by optimization the culture medium would improve its presenting ability and have a potential value in design and application individual vaccine. Although antigens pulsed DCs have a decrescent antigen presenting ability but BCG HSP70 could induce its mature and improve its presenting ability. Suggests BCG HSP70 would be a useful mature inducer. Lymphocytes primed by DCs based HC vaccine have the specific cytotoxicity against HCC lines. The CTL after freezing and anabiotic could prophylaxis and therapy HC xenograft on nude mouse. The results also suggests that CD4〓 lymphocytes play a important role in HC with a good differentiation and would be useful in treatment this kind of HC. After being activated by Peptide LLNQHACAV of hAFP and apoptotic HCCs pulsed DCs respectively, the culture medium of activated lymphocytes both contains a high level Th1 cytokines IL-12 and TNF. Primed lymphocytes appeared a characteristic of NK cells. DCs not only inhibited the growth of human HCC and other cancer cells in vitro but also prevented the growth of HC xenograft on nude mouse in vivo. There are at least three kinds of mechanism playing important role in DC based vaccine ,there are inhibition of DCs, HC specific CTL and cytokines pathway.

诱导出的DC共同表达CD83和CD14分子，CD83分子表达明显高于国内报道；肝癌患者DC培养上清中TNF水平高于健康人，提示肝癌患者DC仍具一定的抗原呈递能力，适当调控可使其行使APC功能，以期在肝癌个体化疫苗中发挥作用；DC负载肝癌可溶性抗原后，抗原呈递能力降低，BCG HSP70可促进DC成熟，增加其抗原呈递能力，预示BCG HSP70有可能成为促进DC活化和成熟的另一重要分子；肝癌DC疫苗在体外诱导肝癌特异性淋巴细胞，活化的淋巴细胞在体外对肝癌细胞的杀伤以特异性CTL为主，同时分泌较高水平Th1型细胞因子IL-12和TNF，并抑制4种肝癌细胞生长；冷冻复苏后的肝癌特异性淋巴细胞可以预防和抑制人肝癌裸鼠皮下移植瘤，提示DC负载肝癌可溶性抗原后诱发的MHC-Ⅱ类限制性CD4〓T细胞有可能在分化程度高的肝癌治疗中发挥作用；用DC和HLA-A2〓DC分别负载凋亡肝癌细胞和hAFP218-226位LLNQHACAV HLA-A2限制性九肽，在体外诱导肝癌特异性淋巴细胞，活化后的CTL细胞分泌较高水平的Th1型细胞因子IL-12和TNF，并具较强杀伤活性，此CTL同时具备NK细胞特征；DC对肿瘤细胞的抑制作用可能是通过吞噬实现的，Fas-L在DC抑制中也起一定作用；DC对人肝癌裸鼠皮下移植瘤的抑制率为97％；在肝癌DC疫苗的作用中，至少联合3种以上机制，即通过DC的直接作用、肝癌特异性CTL和细胞因子途径直接或间接地杀伤和抑制肝癌细胞。

I've seen some good men get blown over G-packs In the Bronx where it's known to hear the heat clap And live niggaz get it on with the D-techs, SHIT, my life's legendary If I wrote down all in a book it would be very scary What you know 16 be missin' Benzes Rope chain down to my dick, the beef looks tremendous Me and my niggaz flip holes in bitches Back then, when I wouldn't even pose for bitches A-YO, you can ask dapadan who was the man Back in 88, every other week tricked 30 grand Even my bitches wore Gucci and Louie My peeps already in the crowd looking for groupies to screw me Exit the club, about to cruise up the block now with the taj, stay frontin' with top down See me in that new thing with my fiancee Ass so fat, making you say "Muchos GRANDE" Don't blame me, blame them, the white folk for giving me ten mil, for possessin' the tight flow WHOA [Chorus: repeat 2X] Ya'll wanna live my lifestyle Never seen a brick, never seen a crackhouse Wanna a war with the Don have your techs out Bring it on, and I'm show you gangsta [Verse 2] Yeah, yeah, uh, yo, blow half your head off, leave you with brain damage He got his shit rocked cause he didn't pay homage It's the Don of this rap shit, go on with that wack shit Heard you walked the dorm in a thong on your last bid Joey Crack is, the most official Toke the pistol for those who appose the issue I hope I convinced you to back up, really you acted up, believe me I could EASILY GET YOUR ASS TOUCHED And that sucks, ain't nobody could fuck with this Bullet shook could make you take a bucket of piss For runnin' your lips Got the fifth stuck in your ribs, don't make me...

我见过一些好的男人得到吹超过国包在布朗士区，它在已知听到热拍住niggaz得到它同为d -科技股， shit的，我的一生的传奇如果我写下来的一本书，这将是非常可怕的你知道16 missin ' benzes 绳链，以我的迪克，牛肉看起来巨大我和我的niggaz倒装孔犬当年，当我甚至不构成对犬-顿，你可以要求dapadan谁是男子早在88 ，每隔一周骗30大甚至我的犬穿着诺特美联社11 我的peeps已经在人群中寻找groupies以螺丝我退出俱乐部，即将邮轮了，现在座与泰姬陵，逗留frontin '由上而下见我在这件新鲜事，我的未婚妻群丛，使脂肪，使你说& muchos重创&不要怪我，责怪他们，白民歌给我10 mil ， possessin '紧迫流 whoa [合唱：重复2倍速] ya'll想住我的生活方式从未见过砖，从未见过crackhouse 想要战争与顿河有你的科技股列使之对，我敢表明您gangsta [韵文2 ] 嗯，嗯，嗯，协青社，打击了一半，你的脑袋过，留给你的脑损伤他得到了shit的轰动的原因，他不来顶礼膜拜它的顿河的此次rap shit的，继续与wack shit的听到你走到公寓在一个通对你的最后一个申办乔伊裂纹，最正式 toke手枪对于那些appose问题我希望我确信你回来了，真是你们的行动了，请相信我我可以轻易获得您的依次为感动并且吸收，是不是任何人都无法他妈的这子弹震撼了，可以使你的一桶独立私校为runnin '你的嘴唇获得第五停留在你的肋骨，不要让我。。。

I thank the gods for giving me such a brother, who was able by his moral character to rouse me to vigilance over myself, and who, at the same time, pleased me by his respect and affection; that my children have not been stupid nor deformed in body; that I did not make more proficiency in rhetoric, poetry, and the other studies, in which I should perhaps have been completely engaged, if I had seen that I was making progress in them; that I made haste to place those who brought me up in the station of honour, which they seemed to desire, without putting them off with hope of my doing it some time after, because they were then still young; that I knew Apollonius, Rusticus, Maximus; that I received clear and frequent impressions about living according to nature, and what kind of a life that is, so that, so far as depended on the gods, and their gifts, and help, and inspirations, nothing hindered me from forthwith living according to nature, though I still fall short of it through my own fault, and through not observing the admonitions of the gods, and, I may almost say, their direct instructions; that my body has held out so long in such a kind of life; that I never touched either Benedicta or Theodotus, and that, after having fallen into amatory passions, I was cured; and, though I was often out of humour with Rusticus, I never did anything of which I had occasion to repent; that, though it was my mother's fate to die young, she spent the last years of her life with me; that, whenever I wished to help any man in his need, or on any other occasion, I was never told that I had not the means of doing it; and that to myself the same necessity never happened, to receive anything from another; that I have such a wife, so obedient, and so affectionate, and so simple; that I had abundance of good masters for my children; and that remedies have been shown to me by dreams, both others, and against bloodspitting and giddiness...; and that, when I had an inclination to philosophy, I did not fall into the hands of any sophist, and that I did not waste my time on writers of histories, or in the resolution of syllogisms, or occupy myself about the investigation of appearances in the heavens; for all these things require the help of the gods and fortune.

我感谢神明给了我这样一个兄弟，他能以他的道德品格使我警醒，同时又以他的尊重和柔情使我愉悦；感谢神明使我的孩子既不愚笨又不残废，使我并不熟谙修辞、诗歌和别的学问，假如我看到自己在这些方面取得进展的话，本来有可能完全沉醉于其中的；我感谢神明使我迅速地给予了那些培养我的人以他们看来愿意有的荣誉，而没有延宕他们曾对我寄予的愿我以后这样做的期望（因为他们那时还是年轻的）；我感谢神明使我认识了阿珀洛尼厄斯、拉斯蒂克斯、马克西默斯，这使我对按照自然生活，对那种依赖神灵及他们的恩赐、帮助和灵感而过的生活得到了清晰而巩固的印象，没有什么东西阻止我立即按照自然生活，然而我还是因为自己的过错，因为没有注意到神灵的劝告（我几乎还可以说是他们的直接指示）而没有达到它；我的身体置于这样一种生活之外如此之久，我从未达到本尼迪克特或西奥多图斯的高度，但在陷入情欲之后，我还是被治愈了；虽然我常常达不到拉斯蒂克斯的那种气质，但还是没有做过使我悔恨的事情；虽然我母亲不能尽其天年而终，但她最后的年月是与我在一起的；在我希望帮助任何需要帮助的人的时候，或在任何别的场合，我都不感到我缺乏这样做的手段；而对我自己来说却不会有同样的需要：即需要从别人那里得到的东西；我有一个十分温顺、深情和朴实的妻子；我有许多优秀的教师来教育我的孩子；通过梦和其他办法，我发现各种药物来治疗咯血和头昏……当我有一种对哲学的爱好时，我没有落入任何诡辩家之手，没有在历史作品上，或者在三段论法的解决上浪费时间，也没有专注于探究天国的现象；而上面所有这些事情都要求有神灵和命运的帮助。

For example, in one of the English classese in Canada last year, the instructor was talking about the world-frightening news, the Tian An Men event that happened in 1989, which was telling that the China government used the military power to bloodily suppress the students who were holding the campaign to seek the democracy. This event was so familiar to all of us Taiwanese, Japanese, and Korean students, but totally strange to those studnets from China.

举例来说，去年在加拿大念语言学校的某一堂课中，老师提到了1989年震惊全世界的天安门事件：中共政府运用军事武力血腥镇压追求民主政治的大学生，这件事在我们班上少数的台湾人，日本人，和韩国人都耳熟能详，但其余来自大陆的学生却是一脸困惑，后来一问才知道他们在这辈子，无论是在学校，在家里，在媒体，还是在书刊上，都完全没听说过这件事情。

I didn't know what day it was when you walked into the room I said hello unnoticed You said goodbye too soon Breezing through the clientele spinning yarns that were so lyrical I really must confess right here the attraction was purely physical I took all those habits of yours that in the beginning were hard to accept Your fashion sense, Beardsly prints I put down to experience The big bosomed lady with the Dutch accent who tried to change my point of view Her ad lib lines were well rehearsed but my heart cried out for you Chorus: You're in my heart, you're in my soul You'll be my breath should I grow old You are my lover, you're my best friend You're in my soul My love for you is immeasurable My respect for you immense You're ageless, timeless, lace and fineness You're beauty and elegance You're a rhapsody, a comedy You're a symphony and a play You're every love song ever written But honey what do you see in me You're an essay in glamour Please pardon the grammar but you're every schoolboy's dream You're Celtic, United, but baby I've decided You're the best team I've ever seen And there have been many affairs Many times I've thought to leave But I bite my lip and turn around 'cause you're the warmest thing I've ever found the end

我不知道那一天是当您走进房间我说您好忽视你说再见太早 breezing通过对象纺纱是这样的抒情我真的必须承认的权利在这里的吸引力，纯粹是身体采取了所有这些习惯你即在开始时均难以接受您的时尚感， beardsly打印我提出到的经验大bosomed夫人与荷兰口音试图改变我的角度来看她的广告库线，以及排练但是我的心呼喊着为您合唱团：您在我心中，您在我的灵魂您将我的呼吸急速，应我长大岁你是我的情人，您是我最好的朋友您在我的灵魂我的爱为你是无法估量的我尊重你的巨大您ageless ，永恒的，蕾丝和细您美丽和优雅您的Rhapsody ，喜剧你是一个交响乐团和发挥您的每情歌以往任何时候都以书面但是，蜂蜜，你有什么见在我您在一篇文章的魅力请原谅语法但您每一个学生的梦想您凯尔特，美国，但婴儿我已经决定您最好的球队我已经见过并有许多事务很多次，我已经想过离开但我咬我的嘴唇和掉头'事业的您致以最热烈的事，我从未发现最后

I didn't know what day it was when you walked into the room I said hello unnoticed You said goodbye too soon Breezing through the clientele spinning yarns that were so lyrical I really must confess right here the attraction was purely physical I took all those habits of yours that in the beginning were hard to accept Your fashion sense, Beardsly prints I put down to experience The big bosomed lady with the Dutch accent who tried to change my point of view Her ad lib lines were well rehearsed but my heart cried out for you You're in my heart, you're in my soul You'll be my breath should I grow old You are my lover, you're my best friend You're in my soul My love for you is immeasurable My respect for you immense You're ageless, timeless, lace and fineness You're beauty and elegance You're a rhapsody, a comedy You're a symphony and a play You're every love song ever written But honey what do you see in me You're an essay in glamour Please pardon the grammar but you're every schoolboy's dream You're Celtic, United, but baby I've decided You're the best team I've ever seen And there have been many affairs Many times I've thought to leave But I bite my lip and turn around 'cause you're the warmest thing I've ever found

我不知道哪一天它是的是什么时候你进入房间我说哈罗不被注意到的你说再见太快轻易通过纺是非常抒情的纱委托人我确实必须坦白就在这里吸引是体格检查纯正是我发生作用那所有的从一开始是的你的习惯是难以接受你的Beardsly加印的时尚感觉我把记在经验名下有荷兰人口音，其设法改变我的她的任意线是的观点的大bosomed女士被好让排练但是我的心脏迫切需要你你是在我的你是的在我的你将是的精神中心脏中我的呼吸是我应该变得老你我的你是的情人是我的你是的在我的精神中最好友我的对你的爱是无法估量我的尊敬你巨大你是长生不老的，永恒，系带子和纤细你是美和风韵你一狂想曲是一个喜剧你是你是的一交响乐和一玩耍每一个情歌曾经被写作但是加蜜于确实你在中看见我什么使甜你是一在魅力中文章请原谅语法但是你是每一个男生的你是的梦凯尔特人的是联合但是当作婴儿般对待我已经断定你是有史以来最最好的我已经看见的队已经有很多我向有想法的许可但是我咬住嘴唇和把原因往回转的你是有史以来最暖和的我已经找出的东西的多次事件

Thus,in Italy in 1914,Antonio Sant'Elia envei-sioned a metropolis of fantastic industrial skyscrapers and multilevel circula-tion in LA Citta Nuova."I conclude in desfavor of preservation,reconstruction,reproduction of ancient monuments,"he declared.In France in 1918,Tony Garnier drew in great picturesque detail La Cite' Industrielle, a complete regional industrial village.In America in 1934,Frank Lloyd Wright constructed a vast miniature model of his imaginary modern town called Broadacre City.But it wasthe great Swiss-born Parisian architect Le Corbusier who,more than any of the other modern mastrs,devoted his energies to envisioing the conse-quences of modern architectural form upon the shape of the contemporary metropolis.His drawings were beautiful,adstract,and widely influential.

因此，在意大利，在1914年，安东尼奥sant'elia envei - sioned大都会离奇的工业摩天大楼和多层次的环流公告在La citta Nuova新&，我结束在desfavor的保存，重建，再现古代纪念碑&，他declared.in法国在1918年，托尼卡尼尔提请在风景如画的大香格里拉详细列举'工业，一个完整的区域产业village.in美国早在1934年，弗兰克劳埃德赖特修建了一个庞大的微型模型，其假想的现代城镇所谓广city.but它wasthe伟大瑞士生于巴黎建筑师柯布西耶的人，比其他任何一种现代mastrs奉献了精力envisioing该conse - quences现代建筑形式后，形成的当代metropolis.his图漂亮， adstract ，而且影响广泛。

"That the doctrine of the Reformed churches concerning predestination, and the points annexed to it, by its own genius and necessary tendency, leads off the minds of men from all piety and religion; that it is an opiate administered by the flesh and by the devil, and the stronghold of Satan, where he lies in wait for all; and from which he wounds multitudes, and mortally strikes through many with the darts both of despair and security; that it makes God the author of sin, unjust, tyrannical, hypocritical; that it is nothing more than interpolated Stoicism, Manicheism, Libertinism, Turcism; that it renders men carnally secure, since they are persuaded by it that nothing can hinder the salvation of the elect, let them live as they please; and therefore, that they may safely perpetrate every species of the most atrocious crimes; and that, if the reprobate should even perform truly all the works of the saints, their obedience would not in the least contribute to their salvation; that the same doctrine teaches, that God, by a mere arbitrary act of his will, without the least respect or view to sin, has predestinated the greatest part of the world to eternal damnation; and, has created them for this very purpose; that in the same manner in which the election is the fountain and cause of faith and good works, reprobation is the cause of unbelief and impiety; that many children of the faithful are torn, guiltless, from their mothers' breasts, and tyrannically plunged into hell; so that, neither baptism, nor the prayers of the Church at their baptism, can at all profit by them;" and many other things of the same kind, which the Reformed Churches not only do not acknowledge, but even detest with their whole soul.

&该学说的革新教会联谊会关于宿命，并分附在它，由它自己的天才和必要的倾向，导致起飞的头脑男子从所有虔诚与宗教；这是一个鸦片类由血肉所魔鬼和据点撒旦，在那里他是在等待所有；从他的伤口众多，而致命打击，通过许多与飞镖都绝望与安全；因为它使上帝的作者单，不公正，专横，虚伪的，即它只不过是多插生活俭朴，摩尼教，放纵， turcism ；这使得男性的肉体关系稳固，因为它们是说服它说，没有任何东西可以阻碍救赎的选举，让他们住，因为他们请；因此，他们可以安全地胡作非为，每一个物种的最残暴的罪行，并认为，如果reprobate甚至应该真正履行全部工程的圣人，他们的服从，将不会在至少贡献出他们的救恩，即同一教义教导说，上帝，由一个单纯的任意行为，他的意志，如果没有起码的尊重，或以单，有predestinated最大的是世界的一部分，以永恒damnation ，并且创造了，他们为了这个目的，即在同一何种方式选举是喷泉和事业的信念和良好的工程， reprobation ，是导致不信者和不虔诚；说，许多儿童的教友们被拆除，无罪，从他们的母亲的乳房，并tyrannically陷入地狱，因此，既不洗礼，也没有祷告的教会，在他们的洗礼，能在所有利润由他们来主宰；&和许多其他东西的同类，而改革教会不仅不承认，但即使是讨厌自己的整个灵魂。

The main characteristics include: the quiet Sun corona has a rapid response to the flare heating, within 2 second the corona temperature increases nearly one order of magnitude, but later such increase becomes very slowly; the downward velocity at early stage of impulsive phase is too small to be negnected; chromospheric evaporation made by conduction shows some intensely, the maximum evaporated velocity may be as large as 1000 km/s; the chromospheric condensation appears just when the chromospheric evaporation takes place and its place always coincide with that of transition region in the early stage; the maximum of chromospheric condensation occurs also in the early stage of impulsive phase, at which the density in condensation may be larger two order of magnitude than that of surround and the downward velocity may be as large as 100 km/s; after the maximum of chromospheric condensation, its strongth decreases gradually but its width becomes greater with time and have a tendency to transport into deep chromosphere; the front of chromospheric condensation heats atmosphere obviously and the temperature in the chromospheric condensation is higher than the original case; the downware velocity of transition region may be greater than 100 km/s at the early stage; when the evaporated material collide at the top of loop, the densityand the presure there increase rapidly, which result in the formation of a shock wave; and so on.

在改善色球辐射损失和精确分辨过渡区的基础上，通过联立求解连续性方程、动量方程和能量方程，构造了一维磁限制性耀斑环在热沉积作用下的大气动力学模型，获得了耀斑热模型下脉冲相早期较为细致的大气演化理论图象，其主要特征是：耀斑对宁静日冕的加热相当迅速，仅2秒钟日冕温度增加即达一个量级，之后日冕温度增加缓慢；脉冲相早期日冕向下速度很小，几乎可以忽略，热传导驱动色球蒸发，其过程较为激烈，蒸发极大速度可达到1000km/s；色球压缩区与色球蒸发几乎同时形成，且在早期其位置总是与过渡区位置重合；色球压缩极大发生在脉冲相早期，其时密度可高于周围约2个量级，向下速度可超过100km/s；色球压缩极大后，其强度逐渐减弱，但宽度明显增大，且渐渐脱离过渡区往色球传播；压缩区内物质温度要高于原先的大气温度；过渡区下降在脉冲相早期相当迅速，可超过100km/s；当蒸发物质在环顶高速相碰时，环顶的密度、压力迅速增大，且温度也有所增加，导致形成激波，其波面以每秒上百公里的速度自环顶向下传播；在脉冲相前期，日冕软x辐射对色球的加热作用可以忽略；等。

Take DMSO swollen treatment and DEA-SO2-DMSO decrystallization treatment for example, the X-ray diffraction and the Tobolsky's intermittent stress relaxation of treated woods were determined during soaking in water, analyzed the effects of water on crystal degree and inter-cohesion of treated woods. According to these continuous relaxation curves measured in water with different temperatures, various thermodynamic quantities were obtained by using Eyring absolute rate theory, and reviewed the chemical reactions in wood which occur in different relaxation process. For the first time quantify these crosslinkings formed in the process of tensional relaxation by using the SMCIR intermittent stress relaxation way, and defined the cross-linking reaction types. In order to find out the contribute of drying to the fixation of deformation of chemically treated wood, stress relaxation of oven-dry untreated and treated wood was measured during the process of temperature elevation and descend, then analyzed the effect of temperature change on relaxation mechanism of treated oven-dry wood. According to continuous relaxation curves of oven-dry treated wood under various constant temperature, calculated the thermodynamics of relaxation process and discussed the mechanism of molecule change in wood, at the same time, also quantified these cross-linkings produced in wood by intermittent method and on the basis of which the model of molecular change during relaxation process of chemically treated was constructed.

以DMSO膨胀处理及DEA- SO2-DMSO非晶化塑化处理为例，测定了两种处理木材在水浸渍过程中的X射线衍射及Tobolsky间歇应力松弛，分析了水对处理木材结晶度及内部凝聚力的影响；通过未处理和两种处理木材在不同温度水中的连续应力松弛测定，应用Eyring的绝对速度反应理论计算并获得了松弛过程中的各热力学量，分析了在水中松弛过程中不同阶段木材内部发生的化学反应；并首次采用SMCIR连续·不连续双曲线应力松弛法定量了轴向拉伸应力松弛过程中木材内部产生的架桥量，明确了交联反应的类型；为了了解干燥对处理木材塑性变形固定的影响，测定了未处理和两种处理绝干木材在温度下降过程和上升过程中的应力松弛，分析了温度变化对处理绝干木材应力松弛的影响；根据多个温度水平下的连续应力松弛测定曲线，计算松弛过程的热力学量，考察了绝干木材在松弛过程中内部发生的分子变化机理，同时也用间歇法定量了木材内部新形成的架桥量，并在此基础上构筑处理木材在松弛过程中内部分子构造的变化模型。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。