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So called reservoir is physical or mathematical; for a physical system, the mathematical model is a system of partial differential equations with related initial and boundary value conditions, it can describe important physical process occurring in the system, for example, the process occurring in reservoir, which mainly concludes flow of fluids and transportation of mass, gravity、 viscosity、compressibility have effect to it; differential equations describing this process are obtained by combining Darcy law of every phase and its mass equilibrium in differential form.

这种模型是物理的或数学的;一个物理系统的数学模型,是偏微分方程组和适当的一组初、边值条件的总体,它能够描述在系统中发生的重要的物理过程,比如在油藏中发生的过程,主要是流体的流动和质量的转移,重力、粘滞力、压缩性等在流体流动过程中都是起作用的;描述这个过程的微分方程是由将各相达西定律和各该相的微分形式的物质守恒相结合而得到的。

In this paper, we studied M. meretrix ferritin, cathepsin B and caspase genes, which are involved in clam larval shell formation, nutrition, metabolism and apoptosis, respectively. We have cloned the three genes, investigated the temporal and spatial expression profile both at gene and protein level in trochophore (L1), D-veliger (L2), pediveliger (L3) and postlarvae (L4). The potential roles of these proteins were analyzed with specific inhibitors during larval development. Firstly, embryos were found developed into trochophore-like larvae with no shell if cultured at gastrula stage in artificial seawater without iron. Shell-like structures were formed only in the presence of iron. The larvae which had been transferred at L1 stage into ASW developed normal shell. This indicated that iron and iron associated protein are important for larval shell formation. The EST sequence which is homologous with ferritin, which is a principal iron metabolic protein, was selected from the M. meretrix cDNA library. The full-length of ferritin subunit cDNA was cloned by RACE. The results of real-time PCR revealed that the MmeFer mRNA expression changed before and after the larval shell formation.

本论文以文蛤幼虫为研究对象,分别对文蛤幼虫发育过程中贝壳形成相关的铁蛋白、营养及变态相关的组织蛋白酶B及变态过程中细胞凋亡相关的caspase三个基因进行了克隆,分析了基因及编码蛋白在担轮幼虫期(L1)、D形幼虫期(L2)、壳顶幼虫期(L3)和稚贝期(L4)的时空表达特征,解析了其可能的功能,并研究了相应酶类的特异性抑制剂作用对幼虫发育过程的影响,进行了目标蛋白的功能验证,详述如下:研究结果显示,在文蛤胚胎发育到原肠胚时放入不含铁离子的人工海水中培养,发育成无壳的畸形,随着人工海水中铁离子添加浓度的升高,幼虫长出壳状组织接近正常状态;而发育到L1期幼虫放入不含铁离子的人工海水中培养却可以发育出正常的壳,推测铁和铁代谢相关蛋白在幼虫贝壳初始形成有重要的作用。

The geology research of carbonate reservoirs in Ordovician of Tahe oilfield showed that many large dissolved vugs and fractures were developed. The spread of the reservoir take on a very heterogeneous state. And the typical fractured-vuggy reservoirs was formed. According to the combination of the various spaces, the formation was divided into vuggy formation, fractured-vuggy formation and fractured formation. The research showed that development of the vug is relevant to the its position on the structure, the fractures, the water surface and the weathering surface. Multi-phase charge and recharge of the oil in the reservoirs resulted in the complexity of the fluid distribution. So the"Bottle Model"was brought forward to explain the movement of the water-oil contact. The special storage space and the complex fluid distribution lead to the unstability of the production and the complexity of the water cut. In order to explain the characteristic of the fracture-vug unit was brought forward and the basic principle and method of the partition of the fracture-vug unit was formed. The classification and evaluation of the units were performed according the reserve and energy. Based on the research of geology characteristic and the fluid flow in the reservoir the comprehensive numerical simulation plan of the fractured-vuggy reservoirs were established. Through the selection of the simulation unit, fluid flow type and parameter equivalent the triple media reservoir simulation model was established. Considering the practical application the model was resolved by the DKR decomposition conjugate grads method. Based on the fine reservoir description of Dsitrict IV of the Tahe oilfield the various space type were classified and combined together. The geology model of Unit S48 was constructed. Two typical single well model was established according to the geology and the dynamic phenomena. Finally the single well model and the Unit S48 were simulated by the triple media reservoir simulator. Via the local grid refinement and coarsening in the simulation good matchs were gained. Based on the results of the simulation the reserve distribution, percent of reserve produced in various space and the natural energy were analyzed. The fluid was storaged in the fractures and vugs mostly and more than 90% the produced oil came from the systems. The energy belonged to the active one. The results of simulation accorded with the fact and showed the validity and practicability the research and the simulator.

塔河油田奥陶系碳酸盐岩油藏的地质研究表明,其储层中发育着很多大型的溶蚀洞、缝,储层的平面展布呈现出极度的非均质性,形成了典型的缝洞型碳酸盐岩油藏,根据各种孔隙介质在储层中的组合,将储层分为了溶洞型、裂缝-溶洞型和裂缝型三类;研究表明溶洞储层的发育和构造位置、裂缝的发育、潜水面和风化面的位置等因素有关;多期充注的油气成藏模式导致了流体复杂的赋存状态,由此提出了所谓的"瓶子模型",解释生产过程中油水界面的变化;特殊的储集空间类型和流体分布特征导致油田在开发过程中表现出很大的不确定性和含水变化的复杂性,为了合理的解释油气田开发过程中的动态特征,提出了"缝洞单元"的概念,并制定了"缝洞单元"纵横向划分的基本原则和依据及划分方法,并对"缝洞单元"进行了分类和评价;基于地质特征和流体在其中流动规律的研究,提出了缝洞型碳酸盐岩油藏的数值模拟综合解决方案,通过模拟单元的选择、流动类型和参数的等效,建立了三重介质油藏三维三相数值模拟模型,采用不完全LU分解预处理共轭梯度法进行了求解;在塔河油田4区精细油藏描述的基础上,将各种类型的孔隙空间进行了归类组合,建立了S48单元的地质模型;通过对油井生产动态进行分析研究,建立了两类和油井地质、生产动态相对应的单井模型;最后应用三重介质油藏数值模拟软件对单井模型和S48单元进行了数值模拟,通过局部加密和粗化等技术模拟流体流动规律,取得了很好的拟合效果;结合数值模拟结果,分析了各种介质中的储量分布、储量产出的百分比以及地层的能量,认为塔河油田缝洞型油藏中流体绝大多数储集于缝洞系统之中,所产出流体90%以上也来自于缝洞系统,其底水能量属于较充足的类型;模拟结果和油田实际情况符合较好,说明了地质研究和油藏数值模拟研究的正确性。

The implementing process of TI in EMS is partitioned into two periods including product conception development and product technology development. The model of product conception development is built which is composed of demands identifying, technological modules identifying and conception appraisement. In the period of product technology development, the identification model of knowledge on new product is constructed at first. Enterprises should beware of selection and integration of the relative domain-specific knowledge, and do product innovation continuously by product platform approach based on the integration of outer technology resource efficiently. The view is put forward that Chinese EMI enterprises should do TI with self-innovation, and only by this way could enterprises build undependent technological capability and keeping product innovation continuously.

针对复杂产品概念设计过程建立由需求识别、技术模块明晰和评价反馈二部分组成的产品概念设计模型,认为成功的产品概念设计是经过以上流程所最终确定的;产品技术开发阶段,首先建立了新产品技术知识的识别模型;企业在产品技术开发过程中应该注意领域知识的选择与集成,在有效利用外部技术源的基础上,实现基于产品平台的产品创新;以大连机车车辆厂、哈尔滨电机厂等我国知名装备制造业企业为例,提出我国装备制造业企业在应用技术集成方法过程中,应该注重将技术集成与自主创新近性有机结合,以期有效突破企业产品技术发展过程中的瓶颈,实现产品技术的持续创新。

The geology research of carbonate reservoirs in Ordovician of Tahe oilfield showed that many large dissolved vugs and fractures were developed. The spread of the reservoir take on a very heterogeneous state. And the typical fractured-vuggy reservoirs was formed. According to the combination of the various spaces, the formation was divided into vuggy formation, fractured-vuggy formation and fractured formation. The research showed that development of the vug is relevant to the its position on the structure, the fractures, the water surface and the weathering surface. Multi-phase charge and recharge of the oil in the reservoirs resulted in the complexity of the fluid distribution. So the"Bottle Model"was brought forward to explain the movement of the water-oil contact. The special storage space and the complex fluid distribution lead to the unstability of the production and the complexity of the water cut. In order to explain the characteristic of the fracture-vug unit was brought forward and the basic principle and method of the partition of the fracture-vug unit was formed. The classification and evaluation of the units were performed according the reserve and energy. Based on the research of geology characteristic and the fluid flow in the reservoir the comprehensive numerical simulation plan of the fractured-vuggy reservoirs were established. Through the selection of the simulation unit, fluid flow type and parameter equivalent the triple media reservoir simulation model was established. Considering the practical application the model was resolved by the DKR decomposition conjugate grads method. Based on the fine reservoir description of Dsitrict IV of the Tahe oilfield the various space type were classified and combined together. The geology model of Unit S48 was constructed. Two typical single well model was established according to the geology and the dynamic phenomena. Finally the single well model and the Unit S48 were simulated by the triple media reservoir simulator. Via the local grid refinement and coarsening in the simulation good matchs were gained. Based on the results of the simulation the reserve distribution, percent of reserve produced in various space and the natural energy were analyzed. The fluid was storaged in the fractures and vugs mostly and more than 90% the produced oil came from the systems. The energy belonged to the active one. The results of simulation accorded with the fact and showed the validity and practicability the research and the simulator.

塔河油田奥陶系碳酸盐岩油藏的地质研究表明,其储层中发育着很多大型的溶蚀洞、缝,储层的平面展布呈现出极度的非均质性,形成了典型的缝洞型碳酸盐岩油藏,根据各种孔隙介质在储层中的组合,将储层分为了溶洞型、裂缝-溶洞型和裂缝型三类;研究表明溶洞储层的发育和构造位置、裂缝的发育、潜水面和风化面的位置等因素有关;多期充注的油气成藏模式导致了流体复杂的赋存状态,由此提出了所谓的&瓶子模型&,解释生产过程中油水界面的变化;特殊的储集空间类型和流体分布特征导致油田在开发过程中表现出很大的不确定性和含水变化的复杂性,为了合理的解释油气田开发过程中的动态特征,提出了&缝洞单元&的概念,并制定了&缝洞单元&纵横向划分的基本原则和依据及划分方法,并对&缝洞单元&进行了分类和评价;基于地质特征和流体在其中流动规律的研究,提出了缝洞型碳酸盐岩油藏的数值模拟综合解决方案,通过模拟单元的选择、流动类型和参数的等效,建立了三重介质油藏三维三相数值模拟模型,采用不完全LU分解预处理共轭梯度法进行了求解;在塔河油田4区精细油藏描述的基础上,将各种类型的孔隙空间进行了归类组合,建立了S48单元的地质模型;通过对油井生产动态进行分析研究,建立了两类和油井地质、生产动态相对应的单井模型;最后应用三重介质油藏数值模拟软件对单井模型和S48单元进行了数值模拟,通过局部加密和粗化等技术模拟流体流动规律,取得了很好的拟合效果;结合数值模拟结果,分析了各种介质中的储量分布、储量产出的百分比以及地层的能量,认为塔河油田缝洞型油藏中流体绝大多数储集于缝洞系统之中,所产出流体90%以上也来自于缝洞系统,其底水能量属于较充足的类型;模拟结果和油田实际情况符合较好,说明了地质研究和油藏数值模拟研究的正确性。

They were randomly scarified at 3, 6 and 9 weeks after injection of CCl4 respectively. Their liver tissues were analyzed for histopathological changes. Gene expression of p38MAPK was measured by reverse transcription-PCR and immunohistochemistry was used to detect the protein expression and localization.

取其肝脏观察HF形成过程中不同时间段各组大鼠肝组织病理变化,用RT-PCR技术检测p38MAPK mRNA在造模过程中肝组织中的表达变化,免疫组化方法检测p38MAPK在造模过程中肝组织中蛋白表达量的变化,及其在肝组织中的表达分布情况。

Viscosities of the alloy in cooling are greater than those in heating.Viscosities in cooling with 100℃ superheating are lower than those in cooling without superheating.

熔体在降温过程中的粘度高于升温过程中,在过热100℃后的降温过程中熔体的粘度较之无过热的降温过程中要低。

Its rule of change was obtained. On the basis of other studies, the flocculation kinetics and flocs structure was studied. By making some assumptions, collision frequency were presented. Then the the flocculation kinetics model was established through population balance equation. Comparison of experimental data and modeling results indicate that there are the same trend between the two. So the model can predict flocs number and size during flocculation of Yellow River's loess particles without using empirical parameters. The TEM and SEM were used to obsever flocs in the study of floc structure. The flocculation was divided as flocculi, floc and floc aggregate. The flocs structure model was established by assumption that particles position in floc accords with tetrahedron. The fractal dimension of model and experimental flocs was found to be coincident. So the model can reflect the structure of flocs formed in flocculation of Yellow River's loess particles by macromolecule flocculant at a certain extent.

最后,本文还对絮凝动力学和絮体结构进行了研究,在前人研究的基础上,针对高分子絮凝黄河泥沙,对絮凝过程作了一些符合试验条件的假设,建立了颗粒碰撞频率表达式,应用了颗粒数量平衡方程,从而建立了絮凝过程的动力学生长模型,模型计算结果与试验数据对比表明,二者趋势一致,在没有使用经验参数的情况下基本上能够描述黄河泥沙絮凝过程中絮体数量和尺寸分布的变化过程;对絮体结构的研究中,应用扫描电子显微镜和透射电子显微镜对絮体进行了观察,将絮体分为絮粒、絮团和絮网三个不同的生长阶段,通过假设颗粒结合位置符合正四面体,建立了絮体结构模型,计算得到的模型絮体分形维数基本与试验中的实际絮体相符,在一定程度上能眵反映高分子絮凝黄河泥沙生成的絮体结构。

Its rule of change was obtained.On the basis of other studies,the flocculation kinetics and floes structure was studied. By making some assumptions, collision frequency were presented.Then the the flocculation kinetics model was established through population balance equation. Comparison of experimental data and modeling results indicate that there are the same trend between the two. So the model can predict floes number and size during flocculation of Yellow River's loess particles without using empirical parameters.The TEM and SEM were used to obsever floes in the study of floe structure.The flocculation was divided as flocculi,floc and floe aggregate.The floes structure model was established by assumption that particles position in floe accords with tetrahedron.The fractal dimension of model and experimental floes was found to be coincidentSo the model can reflect the structure of flocs formed in flocculation of Yellow River's loess particles by macromolecule flocculant at a certain extent

最后,本文还对絮凝动力学和絮体结构进行了研究,在前人研究的基础上,针对高分子絮凝黄河泥沙,对絮凝过程作了一些符合试验条件的假设,建立了颗粒碰撞频率表达式,应用了颗粒数量平衡方程,从而建立了絮凝过程的动力学生长模型,模型计算结果与试验数据对比表明,二者趋势一致,在没有使用经验参数的情况下基本上能够描述黄河泥沙絮凝过程中絮体数量和尺寸分布的变化过程;对絮体结构的研究中,应用扫描电子显微镜和透射电子显微镜对絮体进行了观察,将絮体分为絮粒、絮团和絮网三个不同的生长阶段,通过假设颗粒结合位置符西安建筑科技大学博士学位论文合正四面体,建立了絮体结构模型,计算得到的模型絮体分形维数基本与试验中的实际絮体相符,在一定程度上能够反映高分子絮凝黄河泥沙生成的絮体结构。

This paper deals with and summarizes the research and importance of ductile shear zones and presents the future direction and aim for the research of the ductile shear zones around the world. Four aspects of studies of the ductile shear zones have been proposed in this paper as follows:(1) The stress environment including the mineral assemblages, deformation, stress-shearing parameters;(2) The major element sequence and activation under condition of stress;(3) The variations of trace elements and REE, their transportation distributions under strong natural deformation as well as variations of mineral crystal parameters, which can also control the element changes during the ductile deformation;(4) The relationship between element migrations, activation and stress, which will present the new evidences for the studies of dynamic diagenesis and mineralization as well as the studies of evolution of ductile shear zones developed in middle and low levels.(5) The analysis of elements and isotopes in mylonites on the micro-scale are crucial for the understanding of component migrations during the mylonization.

对韧性剪切带及其变形岩石的研究现状和研究意义进行系统的综述,提出了未来韧性剪切带及其糜棱岩的研究方向和目标:①系统研究糜棱岩中主要造岩矿物组合及其变形特征,计算剪切变形岩石的应力-应变参数,搞清韧性剪切带所处的应力应变环境;②系统研究韧性剪切带岩石在天然分强剪切应力作用条件下常量元素迁移机制及活化转移的应力排序问题;③系统研究剪切变形作用过程中岩石化学组成的微量和稀土元素变化,讨论强变形条件下岩石中微量元素活化和迁移规律,深入探讨微量元素迁移的动力控制,包括稀土元素配分变化的应力制约以及应变矿物晶格化学变化行为及其对其寄主的变形岩石元素在应变过程中迁移变化的制约和影响;④从理论上探讨天然强剪切应变条件下岩石中组分活化、转移与应力的因果联系,为深入探讨韧性剪切带动力成岩作用提供理论的科学依据,为探讨中、下地壳中韧性剪切带的形成和演化提供科学依据,同时为韧性剪切变形作用条件下成岩、成矿地球化学作用提供理论和实验依据;⑤现代分析技术如激光同位素原位分析以及激光ICP-MASS分析技术对研究变形域内的岩石的元素和同位素的活化迁移规律,对深刻揭示糜棱岩化过程中的元素活化迁移机制提供更高质量的地球化学证据具有重要的作用。

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