因子模型

But there were no statistical differences in these factors between AGEs group and control ones after RAGE were interrupted by siRNA.Conclusion In this study model,the phenomena of increased cell cycle relative factors and inhibited cell proliferation might be one of the endogenous compensating mechanisms in keratinocytes treated with AGEs.This mechanism was correlated with RAGE signal pathway.

在上述体外模型下，表皮角质形成细胞的周期调控因子升高，而增殖却下降且凋亡增加，可能是AGEs干预后细胞内启动内源性代偿调控机制，且这种调控机制与其受体途径相关；AGEs也可能还通过以上细胞周期调控因子以外的其他途径或机制影响细胞生物学功能。

The simulation job of saturator is performed based on the founded model, in which the difference between Lewis factor and Lewis number and also the impact of the Lewis factor value on simulation results is discussed in details.

根据饱和器数学模型，运用数值方法模拟和分析了饱和器的工作特性，重点讨论了Lewis因子和Lewis数之间的关系，并分析了Lewis因子的取值对模拟结果的影响。

Finally, the affected degree of factors is evaluated by applying partial relation coefficient analysis method and single factor weighted index method.

结果表明，二手房市场和新房市场具有明显差异，市场供求是影响二手房价格的最主要因子，而环境质量则是影响新开楼盘价格的首要因子；繁华程度和交通条件的重要影响作用在本次回归模型中没有得到验证。

The stress intensity factors of pipes containing an elliptical arc of crack have been evaluated by collapsed singular element with the more detailed mesh on crack front and their respective adjacent areas.

中文摘要本论文对含内、外裂椭圆形裂缝之圆管应力强度因子计算，计算在椭圆形裂缝尖端部位附近，使用溃点奇异元素，建立有限元素的网格化自动产生模型，并利用ANSYS程式计算裂缝尖端的应力强度因子。

With this method, we had several important differences compared to the YDmodel. First, the ratio of daily increment of PDT and the deficit of both water and nitrogen was used to estimate the effect of environment. Second, a nonlinear function was adopted to describe vernalization and thermal effectiveness (instead of three-stage linear function). Third, sinusoidal function was used to describe photoperiod curve cluster for different cultivars.

本模型在YDmodel基础上的改进主要有3点：（1）将每日生理发育时间的增量乘以水肥丰缺因子，改为除以水肥丰缺因子表现水肥对大麦发育的影响，客观体现了大麦在水肥丰缺条件下的发育延迟或提早现象；（2）将三段线性函数改为非线性函数表达春化效应和相对热效应，确立了不同品种相对春化效应和相对热效应的曲线族；（3）将线性函数改为正弦函数表达不同品种光周期效应。

A transportation engineering research and development program assessment method basing on DEA is formulated for prediction of efficiency index, production possibility set's restraint coefficient and inputoutput slack variable. Then use the reciprocal process of principle factor method to calculate the effective availability of research and development personnel and funds.

并采用构建基于投入的交通科技项目C^2R模型，分析投入因子的效率评价指数、生产可能集约束系数和投入／产出松弛变量，结合因子分析逆向求解得到投入指标的有效值，从而得出交通科技项目投入人员及经费的有效利用率。

The rule of ecological succession was studied in combined anaerobic process treating antibiotic wastewater. The structure and the metabolize model of granule sludge were founded primarily. The bionomic succession was a dynamic process, and would be developed in the perfect ways through control of bionomic factors and non-bionomic factors.

本文同时系统地研究了复合厌氧法处理抗生素废水的微生物群落演替规律，初步建立了处理抗生素废水的复合厌氧反应器中颗粒污泥的代谢模型，并指出，微生物的群落演替是动态的，通过对生态因子和非生态因子的人为调控，可以使演替按照理想的方向发展。

Based on the artificial neural network model, the sensitivity analysis on each variable of model shows that the effect of ring index of diameter at breast height of Cunninghamia lanceolata on sun-spot is even, and the effects of auto-correlated factors of sun-spot on sun-spot are sensitive, which shows that three variables all have significant effects on sun-spot.

并对网络模型中各变量进行灵敏度分析，分析表明，杉木胸径生长的年轮指数对太阳黑子相对数年平均值影响较平坦，而太阳黑子自相关因子Yt-4和Yt-2对太阳黑子相对数年平均值影响较灵敏，3个因子对太阳黑子相对数年平均值均存在一定的影响。

PART 2:The molecular mechanisms of Nontypeable Haemophilus influenzae induced inflammatory response in respiratory epithelial cells Objective:Nontypeable Haemophilus influenzaewas traditionally considered as an extracellular pathogen in respiratory infections.In this study,we established a model of infected cells to confirm NTHI was also a facultatively intracellular pathogen.Mitogen activated protein kinasesare the important signal transduction pathway in mediating inflammatory response induced by NTHI in respiratory epithelium.In this study,we elucidate the impact of NTHI,and its SCF and EP on the expression of MAPK and subsequent proinflammatory mediators.

第二部分：NTHI致呼吸道上皮细胞炎症反应的分子机制研究目的：通过建立呼吸道上皮细胞株的体外NTHI感染模型，确认NTHI在细胞内的存活，观察NTHI及其组分(可溶性胞质成分SCF、外膜蛋白EP)对呼吸道上皮细胞MAPK信号传导通路和后续的前炎症因子表达的影响，并应用特异性ERK-MAPK抑制剂U0126、p38 MAPK抑制剂SB203580特异性阻断下游MAPK信号传导通路，观察它们对呼吸道上皮细胞分泌前炎症因子表达的影响。

The phasing problem of ACF-1 was solved by the molecular replacement program AMoRe using the crystal structure of habu Ⅸ/Ⅹ-bp as a initial model.

用habu Ⅸ/Ⅹ-bp的晶体结构作为初始模型，运用分子置换法程序AMoRe获得了ACF-1初始相位，使用Ⅹ-PLOR软件包对ACF-1的晶体结构进行修正，最终晶体学R因子利自由R因子分别为0.199和0.266。

As she looked at Warrington's manly face, and dark, melancholy eyes, she had settled in her mind that he must have been the victim of an unhappy attachment.

每逢看到沃林顿那刚毅的脸，那乌黑、忧郁的眼睛，她便会相信，他一定作过不幸的爱情的受害者。

Maybe they'll disappear into a pothole.

也许他们将在壶穴里消失