因子

Autosomal dominant polycystic kidney disease , one of the most common monogenetic human disorders, is characterized by the formation and progressive expansion of multiple cystic lesions, which compromise the function of normal renal parenchyma and lead to nearly 10％ of cases of end-stage renal failure in adults.

中文题名角质细胞生长因子在ADPKD肾囊肿组织中的表达及对囊肿衬里上皮细胞增殖作用的研究副题名外文题名 Expression of keratinocyte growth factor in ADPKD cystic tissue and effect of proliferation on ADPKD cyst-lining epitheliar cells 论文作者刘沙勤导师梅长林朱有华教授学科专业内科学研究领域\研究方向学位级别博士学位授予单位第二军医大学学位授予日期2002 论文页码总数104页关键词角质细胞生长因子肾病囊肿衬里上皮细胞株肾囊肿馆藏号BSLW /2003 /R692 /1 ADPKD是人类为之付出昂贵代价的一种全身性遗传性疾病，是引起慢性肾功能衰竭的第四位病因，在临床上以肾脏满布大小不一并不断增大的囊性液泡、最终引起肾功能进行性损害为特征性的改变。

METHODS: Fetal liver was obtained sterilely. Monoplast suspension was collected by collagenase digestion and mechanical separation, and then centrifuged using 1.070 g/mL Percoll separating medium and 1.077 g/mL Ficoll separating medium. Cells achieved from the interface of separatory liquids were cultured in DMEM/F12 medium, supplemented with 0.1 volume fraction of fetal bovine serum, 20 μg/L hepatocyte growth factor and 40 μg/L epidermal growth factor, for 9 days.

无菌状态下取出胎儿肝脏，以胶原酶消化法和机械分离法获得胎儿肝脏来源单细胞悬液，分别采用1.070 g/mL Percoll分离液和1.077 g/mL Ficoll分离液进行密度梯度离心，吸取界层细胞，添加含体积分数为0.1 FBS、20 μg/L肝细胞生长因子、40 μg/L表皮生长因子的DMEM/F12新鲜培养基诱导9 d。

After transfer of 13 twin blastocysts to recipients, 3 and 2 twin fetuses were obtained, These findings indicate that monozygotic twin mice can be produced more efficiently from F1 embryos than from CD-1 embryos.

在添加生长因子与未添加生长因子的胚胎中，分别有92％和86％的胚胎发育为孪生囊胚。13对胚胎移植后，分别产生了3对和2对孪生小鼠。

Objective To observe the expression and distribution of bone morphogenic protein, transforming growth factor－β and basic fibroblast growth factor in fracture healing so as to find out their action mechanism.

摘 要：目的观察骨形态发生蛋白、转化生长因子－β、碱性成纤维细胞生长因子在骨折修复中的表达及分布情况，进而探讨其作用机制。

BACKGROUND: Bone morphogenic protein 2 is one of the most important growth factors in the healing of bone fracture. The main function is to promote the undifferentiated mesenchymal cells and bone cells to recruitment and differentiate. It is the promoter of bone formation. The BMP-2 gene is an ideal gene that can be used to repair the bone.

背景：骨形成蛋白2是骨基质中最重要骨生长因子，主要生物学作用是促进未分化的间充质细胞和骨系细胞的募集和分化，是骨生成的启动因子，可以作为骨修复基因治疗的理想目的基因。

Hepatocyte growth factor/scatter factor is a multifunctional cytokine with mitogenic, motogenic, and morphogenic activities for renal tubular cells.

肝细胞生长因子是一个对肾小管上皮细胞具有强烈丝裂原活性以及细胞运动与形态调节的多效性细胞因子。

Immune thrombocytopenic purpura is an autoimmune disorder characteriezed by a low platelet count and mucocutaneous bleeding. Some research shows that the cytokines network disorder result from the abnormal level of cytokine play an important role in the pathogenesis of ITP.

免疫性血小板减少性紫癜是一种以血小板减少和皮肤粘膜出血为特征的自身免疫性疾病，研究表明细胞因子水平的异常导致的细胞因子网络失衡在ITP发病中具有重要作用。

AIM To study the long-term toxicity of modified recombinant human tumor necrosis factor rhTNF-NC in Macaca mulatta compared with recombinant human tumor necrosis factor rhTNF.

目的 研究新型重组人肿瘤坏死因子rhTNF-NC iv对恒河猴的长期毒性，并与重组人肿瘤坏死因子rhTNF作比较。

In this research the multinuclear giant cells with the phenotypes of mature osteoclasts were isolated and purified from human giant cell tumour of bone.

但雌激素对这些调节因子的作用机制和雌激素缺乏时这些因子的变化特征仍未阐明。

Thus, IDH1 appears to function as a tumor suppressor that, when mutationally inactivated, contributes to tumorigenesis in part through induction of the HIF-1 pathway.

因而异柠檬酸脱氢酶-1(IDH1)似乎是作为一种肿瘤抑制因子而存在，一旦通过突变使之灭活，则可能会部分的通过缺氧诱导因子亚单位α（HIF-1α）的途径而参与肿瘤的发生。

The labia have now been sutured together almost completely.The drains and the Foley catheter come out at the top.

此刻阴唇已经几乎完全的缝在一起了，排除多余淤血体液的管子和Foley导管从顶端冒出来。

To get the business done, I suggest we split the difference in price.

为了做成这笔生意，我建议我们在价格上大家各让一半。