四碱的

We attached for the first time -NOBIN to Frechet-type dendron units. The syntheses of 16 kinds of dendrimer-based NOBIN Schiff-base ligands were achieved in a straightforward manner by simple condensation of -NOBIN with the corresponding salicylicaldehyde derivatives, of which 12 belong to the dendritic Schiff-base ligands and 4 belong to the non-dendritic Schiff-base ligands.

通过手性拆分获得了光学纯化合物NOBIN，首次将NOBIN手性单元连接到树枝状大分子中去，设计合成了四个系列16种新的NOBIN衍生的希夫碱三齿手性配体，其中4种为非树枝状手性希夫碱配体，12种为树枝状手性希夫碱配体。

These dendritic NOBIN derived Schiff base ligands have been applied to titanium catalyzed hetero-Diels-Alder reaction of Danishefshy's diene and aldehydes, affording the corresponding 2-substituted 2, 3-dihydro-4H-pyran-4-one in quantitative yields and excellent enantioselectivities (up to 97. 2%ee). Comparing the reactivities and enantioselectivities of reaction catalyzed by the titanium complexes of these Schiff base ligands, it was found that a series of ligands L〓 were superior to the other three series of ligands L〓, L〓 and L〓, a significant positive NLE and a dendrimer effect existed in the L〓 dendritic catalyst system. The disposition of the dendritic wedges and the dendron size in the ligands were observed to have a significant impact on the enantioselectivity of the reaction.

NOBIN衍生的树枝状大分子希夫碱手性配体与钛形成的配合物在催化不对称杂Diels-Alder反应中的应用将得到的四个系列NOBIN衍生的树枝状希夫碱三齿手性配体与四异丙氧基钛形成的配合物用于催化Danishefsky's diene与醛的不对称杂Diels-Alder反应，通过反应条件的优化，获得了定量的收率和最高达97.2％ee值的对映选择性；考察了这四个系列NOBIN衍生的树枝状希夫碱钛配合物的催化活性和对映选择性，结果发现它们的活性次序依次为L〓≈L〓＞L〓＞L〓，对映选择性次序依次为L〓＞L〓＞L〓＞L〓。

Four white-rot fungi, Pleurotus eryngii, Polyporus versicolor, Pleurotus ostreatus and Fomes lignosus, are tested for their abilities to produce lignin peroxidase, manganese peroxidase and laccase in N-limited and N-rich media with shake culture. The four white-rot fungi only produce manganese peroxidase and laccase. Pleurotus eryngii and Pleurotus ostreatus are selected, due to their high enzyme activities, for the degradation and decolorization of alkali lignin.

首先观察了四种白腐菌Pleurotus eryngii，Polyporusversicolor，Pleurotus ostreatus和Fomes lignosus在限氮和富氮培养基中振荡培养产木素过氧化物酶、锰过氧化物酶和漆酶的能力，由于Pleurotus ostreatus和Pleurotus eryngii产酶能力较强，用于碱木素的降解脱色效果较好，二者在限氮条件下11天对碱木素降解脱色率为65%和72%。

Cephalotaxine ester of 2-oxo-6-methylheptanoic acid was treated with lithium diisopropylamide and Me O-(1-methoxyisopropyl)glycolate to give a mixture of homoisoharringtonine and its stereoisomers with 56% yield. The four stereoisomers separated by TLC showed identical mass spectra and almost superimposed IR but with different 1H NMR spectra. The configuration of the 2'-C and 3'-C of the four isomers were postulated based upon their 1H NMR spectra as compared with the 1H NMR spectra of isoharringtonine and its stereoisomers.

2-氧代-6-甲基庚酰基三尖杉碱(3)与0-(1-甲氧基异丙基)羟基乙酸甲酯(4)在强碱性试剂二异丙胺锂存在下，起亲核加成反应，反应中间体5在室温用酸性丙酮水解，得到一种新的三尖杉酯类生物碱一一高异三尖杉酯碱(6c)及其立体异构体(6a、6b、6d)的混合物，产率56%、通过制备薄层层析分得这四个立体异构体，它们的1H NMR和异三尖杉酯碱及其立体异构体的1H NMR类似，推定了它们的绝对构型。

Those formed during the flare-up period, i.e., the Pana Formation, however, show significant geochemical variations from low-K tholeiitic through calc-alkaline to shoshonitic compositions coupled with increasing enrichment in LREEs. Therefore, the volcanic successions are divided into four suites, namely, calc-alkaline suite, low-K suite, high-REE suite and shoshonitic suite.

在大喷发时期产生的火山岩最不均质，组成从低钾拉斑质、钙碱质变化到钾玄质，并且呈现不同程度的轻稀土元素富集，我们据此可将本期林子宗火山岩区分为钙碱质系列（calc-alkaline suite）、低钾系列（low-K suite）、高稀土系列（high-REE suite）和钾玄系列四类。

The effects of solvents and salts on the formation of a third liquid phase, distribution of catalyst, reaction mechanism and reaction rate in the reaction between n-butyl bromide and sodium phenolate with tetrabutylammonium bromide as a phase transfer catalyst were investigated.

中文摘要本文系针对以溴化四丁基铵为相间转移触媒催化正溴丁烷与酚化钠之反应，研究溶剂种类及盐类与碱类之添加量对形成第三液相、触媒分布、反应机构及反应速率之影响，被测试之溶剂包括氯苯、甲苯与正己烷，而在盐类与碱类效应的研究中，则测试溴化钠与氢氧化钠。

To produce the scientific evidence for developing and manufacturing new antitumor drugs.Methods: 1 The inhibitory effect on cell growth of Hela was measured by MTT assay in treated or untreated groups (3.125, 6.25, 12.5, 25, 50μg/ml TAM and control) for three different treatment times (24h, 48h and 72h).2 Apoptosis and cell cycle were measured by FCM in four experimental groups (0, 4, 16, 40μg/ml TAM) for 48h.3 Adopting Wright and Giemse's staining to observe the morphology of Hela cells which treated with 40μg/ml TAM.4 Using invasion experiment to detect the Hela cells'invasive abilities which treated with 40μg/ml TAM.5 The protein expressional levels of P-ERK, ERK, C-myc and Cyclin D1 in Hela cells untreated or treated with 4, 16, 40μg/ml TAM for 24h were measured by Western blot.6 Expression of anti-apoptotic gene bcl-2, apoptotic gene bax and MMP-9 in Hela cells of four experimental groups (0, 4, 16, 40μg/ml TAM for 24h), were observed by revers transcription PCR.7 The protein expression of P-ERK, ERK, Bcl-2 and Bax in Hela cells treated with 40μg/ml TAM for 24h observed by laser scanning microscopes.

1采用四甲基偶氮唑蓝法检测不同浓度北豆根总碱(3.125、6.25、12.5、25、50μg/ml)处理不同时间(24、48和72小时)对Hela细胞增殖反应的抑制作用。2采用流式细胞技术(flow cytometry，FCM)检测不同浓度北豆根总碱(0、4、16、40μg/ml)作用48小时，对Hela细胞凋亡及周期变化的影响。3瑞氏-姬姆萨染色后显微镜观察北豆根总碱(0、40μg/ml)作用24小时后Hela细胞形态学变化。4采用Transwell小室法检测北豆根总碱(0、40μg/ml)作用24小时后对Hela细胞侵袭性的影响。5采用免疫印迹方法检测不同浓度北豆根总碱(0、4、16、40μg/ml)作用24小时后，Hela细胞中磷酸化ERK、ERK、C-myc、CyclinD1的表达变化。6采用逆转录-聚合酶链反应(revers transcription PCR，RT-PCR)半定量检测北豆根总碱(0、4、16、40μg/ml)作用24小时，Hela细胞抗凋亡基因bcl-2、促凋亡基因bax、基质金属蛋白酶-9(MMP-9)的表达变化。7应用激光共聚焦显微镜(laser scanning microscope，LSM)观察北豆根总碱(0、40μg/ml)作用24小时后，Hela细胞内P-ERK、ERK、Bcl-2、Bax蛋白的表达变化。

Mainly engaged in sodium azide, barium azide, three phosphorus nitride Friday, phenyl isothiocyanate, 1 - phenyl -5 - mercapto-tetrazole, 4 - dimethylamino-pyridine, 2 - mercapto--5 -- methyl-1,3,4 thiadiazole, N-hydroxy phthalimide, anhydrous betaine and betaine hydrochloride, such as fine chemical raw materials and medicine, pesticide intermediates of the development, production and sales.

主要从事叠氮化钠，叠氮化钡，五氮化三磷，异硫氰酸苯酯，1-苯基-5-巯基四氮唑，4-二甲氨基吡啶，2-巯基-5-甲基-1，3，4噻二唑，N-羟基邻苯二甲酰亚胺，无水甜菜碱及甜菜碱盐酸盐等精细化工原料及医药、农药中间体的开发、生产和销售。

Objective:An ionpair RPHPLC method was established to determine the amounts of lotusine, liensinine, isoliensinine and neferine in Plumula Nelumbinisimultaneously.

目的：建立同时测定莲子心中四种异喹啉生物碱莲心季铵碱、莲心碱、异莲心碱、甲基莲心碱含量的离子对反相高效液相色谱法。

The design characteristics, flow path and application status of 80 kt/a three-effect and four-part diaphragm evaporation sets designed by themselves were introduced.

介绍了自行设计的8万t/a三效四体隔膜蒸发组合性新工艺装置的工艺设计特点、工艺流程及应用情况，摸索出了使用1套装置同时生产30%和42%液碱的操作方法。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。