四环素

To study the effecacy of heat clearing and Qi regulating prescriptionfor helicobacter felis gastritis in Balb/c mice,sixty model Balb/c mice were randomly allocated to five groups:three HCQRP groups(in 26.6g/kg,13.3g/kg and 6.65g/kg respectively) and triple therapy control group(with metronidazole,tetracycline and bismuth)and saline control group.

为检验清热理气方(蒲公英60g、黄连10g、黄芩10g、枳壳10g、佛手12g、炙甘草6g)对实验性猫胃螺杆菌胃炎的治疗作用。采用复制Balb/c猫胃螺杆菌胃炎模型，以清热理气方大、中、小剂量(分别为26.6g/kg、13.3g/kg、6.65g/kg)给药，以三联疗法(灭滴灵2.6mg、四环素1.3mg、丽珠得乐1.3mg)为阳性对照组，以生理盐水为阴性对照。

Not only can make each kind of yellow teeth, black teeth, fumatory teeth pure white and bright, regarding the center mild tetracyclin tooth, the fluorine spot tooth also may achieve the ideal decolorization effect.

欧诺洁深层增美牙贴不仅能使各种黄牙、黑牙、烟茶渍牙达到洁白亮丽的要求，对于中轻度四环素牙、氟斑牙也可达到理想的脱色效果。

The biomechanical tests showed that two kinds of artificial bones had not significant difference on compressive strength and Young\'s modulus(P＞0.05),while the flexural strength of nano-nacre artificial bone was less than the control group(P＜0.05).3.The results of CCK-8 showed that the difference were not significant in each group,the proliferation of osteoblast reached the peak at the 5th day;7 days after being co-cultured,the total protein content of study group was higher than control group and blank group(P＜0.05),while the difference between control group and blank group was not significantP＞0.05The difference of alkaline phosphatase activities among three groups was not significant(P＞0.05The SEM view showed that osteoblast attached and grew well in two kinds of artificial bone.4.X-ray photography showed that two kinds of powder started to degrade in 2 weeks;this phenomenon became more appear in 4 weeks,nano-nacre powder degraded faster than micron-nacre powder,while the hole shadow was easy to be found;in 8 weeks,all the femoral holes recovered and returned to normal bone mineral density in all groups.Analysis of tetracycline fluorescent double marks in the hard tissue grinding slices indicated that new bone grew fastest around the bone defect area in study group,while most slowly in blank groupP＜0.05 SEM(scanning electron microscope observation showed that nano-nacre powder degraded more quickly.The same result can be found through the demineralized sections morphometric analysis,and both of the composite artificial bones made from those two kinds of nacre powder had the good connection with the adjacent tissue in rats body without apparent inflammatory response.5.X-ray photography showed that rabbit\'s bone defects healed faster in study group since NNAB implanted than in control group since MNAB implanted.At 24 weeks after operation,bone density in radial defects had nearly accessed to the normal area,while lower in control group,and turned up nonunion in blank group;The checking of BMD showed that results in study group were higher than those in control group at 8,16 and 24 week(P＜0.05), and the difference between the BMD values in study group at 24 week and those in blank group was not significant(P＞0.05).The gross specimens showed satisfactory histocompatibility both in study group and in control group,with bone tissue growing from two sides into the center of implanted materials; Normal slices in HE stain and hard tissue grinding slices in Stevenel\'s blue/Van Geison\'s picro-fuchsin stain showed that the bone growth tendency was better in study group than that in control group,and the medullary cavity had been penetrated to the implanted materials in study group at 24 week;Analysis of tetracycline fluorescent double marks in the hard tissue grinding slices indicated that new bone in both groups grew fastest 8 weeks after surgery,while slow down at 16 week.

纳米珍珠层/消旋聚乳酸复合人工骨与微米珍珠层/消旋聚乳酸复合人工骨分别与成骨细胞共培养后，其各时间点CCK-8法检测值与空白对照无显著差异(P＞0.05)，成骨细胞均在第5天达到增殖高峰期；培养7天后，实验组细胞蛋白含量高于对照组及空白组(P＜0.05)，后两者之间则无显著差异P＞0.05碱性磷酸酶活性在三组间均无显著差异(P＞0.05电镜下可见成骨细胞在两种人工骨上都有良好生长贴附能力。4.X-ray显示两种粉体在大鼠股骨骨洞植入第2周时都开始出现了降解，第4周时更为明显，纳米珍珠层粉较之微米珍珠层粉降解更快，而空白对照组骨洞阴影仍可见，至8周时，则所有组骨洞均己闭合修复，X-ray下已不可见原钻孔痕迹，恢复正常骨质密度；硬组织磨片四环素荧光双标记结果显示纳米珍珠层粉植入组较其余两组在骨缺损区周围新骨生长速度更快，空白组速度最慢P＜0.05电镜观察及常规脱钙切片亦可见到纳米粉体降解较快；由以上两种原材料制得的纳米珍珠层/消旋聚乳酸复合人工骨与微米珍珠层/消旋聚乳酸复合人工骨在大鼠体内均与周围组织结合良好，无明显炎症反应。5.X-ray显示纳米珍珠层/消旋聚乳酸复合人工骨植入兔桡骨缺损区后其骨愈合速度较对照组微米珍珠层/消旋聚乳酸复合人工骨植入的快，至植入术后24周，实验组骨缺损区接近正常骨密度，对照组骨缺损区密度较低，空白组则呈现骨不连状态；骨密度测量结果显示术后8周、16周、24周实验组的骨密度值高于对照组(P＜0.05，24周实验组的骨密度值与术前所测得的正常值无显著性差异P＞0.05动物取材大体所见均显示组织相容性良好，骨组织逐渐由植入材料两端向中央生长；常规切片HE染色及硬组织磨片Stevenel\'s blue/Van Geison\'s picro-fuchsin联合染色均可见实验组骨缺损区长势优于对照组，至术后24周，实验组骨髓腔与材料已呈相交通状；硬组织磨片荧光显微镜下观察，两组材料在术后8周处于骨生长最快速时期，16周时速度开始减慢，术后4、8、16周时实验组的新骨生长速度均较对照组的快

Drug sensitivity tests showed that the resistance to gentamycin,levofloxacin,trimethoprim/sulfamethoxazole,rifampin,erythromycin,elindamycin and tetracycline were hish among MuH and MuL strains,and most of these strains were multi-drug resistant.All strains were susceptible to vaneomycin.

药物敏感性试验显示，MuH和MuL菌株对庆大霉素、左氧氟沙星、复方磺胺甲恶唑、利福平、红霉素、克林霉素、四环素的耐药率都较高，且呈多药耐药，但对万古霉素全部敏感。

Studied the coordination chemical reaction of Fe、Co、Ni、Cu、Mg、Ca、Al with TC,OTC,CTC and the ternary association of Co-OTC、Ni-CTC with DAN,we found that the formation of new compounds improved significantly the hydrophilic properties of TCs,the TCs are transformed into hydrophobe from hydrophilic matter.

2研究了Fe、Co、Ni、Cu、Mg、Ca、Al与TC、OTC、CTC之间的配位化学反应和Co-OTC、Ni-CTC与DAN之间的三元缔合作用，发现新化合物的形成显著改善了TC、OTC、CTC的亲水性能，使其由亲水物质转变为疏水物质，有利于提高亲水有机溶剂气浮浮选体系对水样中痕量四环素类抗生素的测定灵敏度和分离/富集效率。

Methods:Animal models of 25 adult mixed breed dogs were established by transverse osteotomy at bilateral iliopectineal crest,which were fixed with ATMFS anterior column connector and steel plate respectively. The animals were examined at 2,4,6,8,and 12 weeks by X-ray,macropathological observation and biomechanical test. Tetracin fluorescent labeling,HE staining,Masson triad colour staining,in situ hybridization and immunohistochemical method were performed and histological image analysis were applied.

建立犬双侧骨盆弓状线骨折的动物模型，分别采用ATMFS前柱固定器和5孔重建钢板内固定，于术后2、4、6、8、12周分别行影像学检查、大体观察及生物力学测试；采用四环素荧光标记法、HE染色、Masson三色染色法、原位杂交法、免疫组织化学法进行组织学观察并图像分析；采用RT-PCR法检测骨折端不同时期骨钙蛋白和核心转录因子mRNA相对表达量的变化。

Happy to doxycycline, tetracycline 36.63%, the highest sensitivity, all above 95%, secondly, to clarithromycin 90.98%, 82.71% azithromycin and roxithromycin 21.8%, to 24.82% ciprofloxacin 41.35% levofloxacin, etc, and 44.36% poor sensitivity conclusion: mycoplasm of common antibiotics have different levels of resistance to the early clinical, so for suspected cases for inspection in order to understand the drug susceptibility, thus, the reasonable use.

对强力霉素，美满霉素，四环素，交沙霉素的敏感性最高，都高达95%以上，第二为克拉霉素90.98%，阿奇霉素82.71%，而对罗红霉素21.8%，环丙沙星24.82%，氧氟沙星41.35%，司巴沙星44.36%等敏感性差结论：支原体对常用抗生素有不同程度的耐药性，因此临床上对尽早的对疑似病例进行送检以了解药药敏情况，从而合理，规范的用药。

Happy to doxycycline, tetracycline 36.63%, the highest sensitivity, all above 95%, secondly, to clarithromycin 90.98%, 82.71% azithromycin and roxithromycin 21.8%, to 24.82% ciprofloxacin 41.35% levofloxacin, etc, and 44.36% poor sensitivity conclusion: mycoplasm of common antibiotics have different levels of resistance to the early clinical, so for suspected cases for inspection in order to understand the drug susceptibility, thus, the reasonable use.

对强力霉素，美满霉素，四环素，交沙霉素的敏感性最高，都高达95%以上，其次为克拉霉素90.98%，阿奇霉素82.71%，而对罗红霉素21.8%，环丙沙星24.82%，氧氟沙星41.35%，司巴沙星44.36%等敏感性差结论：支原体对常用抗生素有不同程度的耐药性，因此临床上对尽早的对疑似病例进行送检以了解药药敏情况，从而合理，规范的用药。

Objective: To investigate the antibiotic resistance and the epidemic situation of penicillin and tetracycline resistance plasmids of Neisseria gonorrhoeae in Changsha area.

目的：了解长沙地区淋病奈瑟菌对抗生素的敏感性以及耐青霉素和耐四环素性质粒的流行情况。

Bone graft incorporation and histomorphometery were evaluated in nondecalcified section.

处死前2周和1周时，经胫前皮下静脉注射四环素溶液(30mg/kg)进行荧光标记。

This one mode pays close attention to network credence foundation of the businessman very much.

这一模式非常关注商人的网络信用基础。

Cell morphology of bacterial ghost of Pasteurella multocida was observed by scanning electron microscopy and inactivation ratio was estimated by CFU analysi.

扫描电镜观察多杀性巴氏杆菌细菌幽灵和菌落形成单位评价遗传灭活率。