四环素

Inside the source apply color to develop process in the tooth in formative of, such as four wreath vegetables deposition is in the tooth essence, will make tooth yellow, brown or dark gray, be called four wreaths plain tooths;If containing fluorine in the drinking water is excessive, may also cause fluorine spot tooth, the tooth noodles presents a white chalk color, the palm tree brown spot piece;If the tooth nerve is bad clay-cold, hemoglobin and germ resolve an outcome to combine to also make tooth black.

内源性着色是在牙齿发育过程中形成的，如四环素沉积在牙本质内，就会使得牙齿变成黄色、棕色或暗灰色，称为四环素牙；如果饮用水中含氟过多，也可能导致氟斑牙，牙面呈白粉笔色、棕褐色斑块；如果牙神经坏死后，血色素与细菌分解产物结合也可使牙齿变黑。

Table 5 Correlation of Cobb angle of rat lumbar spine in anteroposterior radiograph with related genesConclusions:(1)Chirismus and tetracycline have a similar therapeutic effect to relieve the lumbar disc degeneration of rats via inhibiting the expression of COL-1a.

7MMP-3的表达量正常组最低，P.01，与其它各组差异有显著意义；对照组MMP-3的表达量较手法组与四环素组高，P.01，故与该两组间差异有显著意义；手法组MMP-3的表达量比四环素组高，P.05，故两组间差异有意义。

AIM: To establish an HPLC method for simultaneous determination of tetracycline and cortisone acetate in its compound eye ointment.

目的：建立一种同时测定四环素可的松服膏中四环素和醋酸可的松含量的HPLC法。

Results indicate that the serum titers of the two kinds of antibodies all reached 3.2×10^5, however, the antibody produced by the immunogen prepared via glutaraldehyde showed higher affinity. The CTC half inhibition concentration (IC50) was 96.2μgmL^(-1) the detection limit was 6.67ngmL^(-1), and the cross-reaction rate between tetracycline and CTC was 77%. The research layed a good foundation for the detection of the antibiotics in livestock products.

结果表明，2种血清的抗体效价最高均达3.2×10^5%，而戊二醛法制备的抗原产生的抗体具有更高的亲和力，抑制率为50%时的金霉素的质量浓度(IC50)为96.2μmL^(-1)，金霉素的最低检测限为6.67ngmL^(-1)，金霉素和四环素的交叉反应率为77%研究结果为畜产品中四环素类抗生素残留的检测奠定了较好的基础。

Furthermore, the results of the antibiotics sensitivity test of 38 isolates to 24 kinds antibiotics show that all isolates have presented antibiotic resistance disparately as well as multi-resistance. All isolates are sensitive to Cephalosporins antibiotics and Aminoglycosides antibiotics such as Amikacin, Cefazolin, Cefradine, Cefoperazone, and Ceftriaxone. Thirty-eight isolates are extremely resistant to Penicillins antibiotics, Lincomycins antibiotics, Tetracyclines antibiotics and Macrolides antibiotics such as Midecamycine, Lincomycin, Carbenicillin, Tetracycline, Amoxicillin and so on. Antibiotics sensitivity test provides guidance for antibiotic application and scientific foundation from poultry farms.

按世界卫生组织推荐的Kirby-Bauer菌液涂布法对38株大肠杆菌进行24种抗生素的药物敏感性试验，结果表明：38株大肠杆菌均有不同程度的耐药，而且均表现多重耐药；较为敏感的抗生素是头孢菌素类和氨基糖苷类抗生素，其中以阿米卡星、头孢唑啉、头孢拉定、头孢哌酮和头孢三嗪最为敏感；对青霉素类抗生素、林可胺类抗生素、四环素类抗生素和大环内酯类抗生素耐药严重，其中以麦迪霉素、林可霉素、氨苄青霉素、四环素和阿莫西林耐药性最为严重；药物敏感试验为保定、秦皇岛和北京三个地区养鸡业提供科学的用药指南，为药物防治提供科学依据。

Results: The proportion of Gram-negative bacilli rose obviously, so did the opportunistic pathogen's and Yeasts detected rate. Most drug sensitive tests showed the drug-fast rate turned to be high. Escherichia coli, Salmonella and Citrobacter resistant and so on to fluoroquinolones was 57%~97%. These bacteria to imipenem showed excellent activity. Meticillin-resistant-staphylococcus resistant to ciprofloxacin, norfloxacin, clindamycin, tetracycline, erythromycin, cefazolin and ampicillin were 40.9%, 42.4%, 63.6%, 72.2%, 85.9%, 100.0% and 100.0%, respectively Streptococcus and Enterococcus resistant to major β-lactams-penicillin, aminoglycosides, macrolides, tetracyclines and sulfonamides were between 36.0% to 100.0%.

结果：革兰阴性杆菌比例显著升高，条件致病菌和酵母样真菌检出机会显著增多；药敏结果显示多数临床细菌对常用抗生素的耐药趋势在不断上升；大肠埃希菌、沙门菌和枸橼酸杆菌等革兰阴性杆菌对喹诺酮类药物的耐药率达57%~97%，亚胺培南则对阴性杆菌有较高的敏感覆盖率；耐甲氧西林葡萄球菌对环丙沙星、诺氟沙星、氯洁霉素、四环素、红霉素、头孢唑啉和氨苄西林的耐药率分别为40.9%、42.4%、63.6%、70.2%、85.9%、100.0%和100.0%；链球菌和肠球菌对多数β内酰胺类青霉素、氨基糖苷类、大环内酯类、四环素类以及磺胺类药物均呈高度耐药，耐药率在36%~100%。

The regulatory elements of the tetracycline resistance operon of Eschenchia coli, Tet repressor and Tet operator, have served as the basis for the establishment of heterologous repression-based inducible system in many eukaryotes including yeast, plants, insects, mammals and parasitic protozoa, such as Trypanosomes, Entamoeba, Giardia, Toxoplasma, Leishmania and Trichomonas.

基于四环素抑制子(Tetracycline Repressor，TetR)和四环素操纵子(Tet Operator，TetO)相互作用的四环素可诱导转基因表达系统，已经广泛的应用于很多真核生物，包括酵母、植物、昆虫、哺乳类细胞和诸如锥虫、阿米巴、贾第虫、弓形虫、利什曼和毛滴虫的寄生原虫。

The ability of magnesium trisilicate to adsorb tetracycline and its relation to pHof the medium have been investigated UV-spectrophotometrically.

本文应用紫外分光光度法研究了体外三硅酸镁吸附四环素的能力及其与介质 pH 的关系；并应用尿药法研究了三硅酸镁及其在表面活性剂和枸橼酸的存在下对四环素吸收的影响；测定了三种不同处方的四环素混悬剂的相对生物利用度并进行了有关参数的统计比较。

The mc2155 carrying pMind-glmU-AS was induced by different concentration of tetracycline, and GlmU protein was detected in the mc2155 carrying pMind-glmU-AS by Western blotting. The results showed that tetracycline of 20ng/ml has obviously inhibited the growth rate of mc2155 carrying pMind-glmU-AS, but the amount of GlmU protein did not change compared to that of uninduced mc2155 carrying pMind-glmU-AS.

glmU反义RNA的诱导表达与GlmU蛋白的检测分别用5 ng/ml、10 ng/ml和20 ng/ml的四环素诱导携带pMind-glmU-AS表达载体的mc~2155菌株表达反义RNA，绘制细菌生长曲线，结果表明20 ng/ml浓度的四环素可抑制mc~2155/pMind-glmU-AS的生长，但Western Blotting分析结果显示经四环素诱导和未诱导的mc~2155/pMind-glmU-AS中，GlmU蛋白表达量无明显的变化。

Tetracyclines (tetracycline, oxytetracycline and chlortetracycline) may be used for either prevention or treatment of bacterial infections.

可能用四环素类抗生素（四环素、土霉素和氯四环素）预防或治疗细菌感染。

This one mode pays close attention to network credence foundation of the businessman very much.

这一模式非常关注商人的网络信用基础。

Cell morphology of bacterial ghost of Pasteurella multocida was observed by scanning electron microscopy and inactivation ratio was estimated by CFU analysi.

扫描电镜观察多杀性巴氏杆菌细菌幽灵和菌落形成单位评价遗传灭活率。