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四氯乙烷

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Propargyl alcohol was protected by dihydrophran with the catalysis of PPTS ,and then reacted with Ethyl Mag bromide to prepare its corresponding Grignard reagent.

炔丙醇在 PPTS 催化下由二氢吡喃保护,与溴乙烷格氏试剂反应生成相应的格氏试剂,然后与氯甲酸甲酯反应得到羟基丁炔酸甲酯四氢吡喃醚,在 PPTS 催化下脱保护后进行甲磺酰化,由溴化钠进行溴取代后合成了4-溴-2-丁炔酸甲酯,总收率达53%。

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