四唑

How to deal with: In recent years there are many symptomatic of the new drugs, high efficacy and few side effects, such as levamisole, mebendazole, etc. Tetramisole suffering from ascariasis children, can, under the guidance of a doctor to take these type of drug treatment.

如何应对：近年来有许多对症的新药，疗效很高，且副作用很少，如左旋咪唑、甲苯咪唑、四咪唑等，患蛔虫病的孩子，可以在医生的指导下服用这类药物治疗。

The chapter 1 introduces the background of imidazole, thiazole, tetrazole derivatives and their glycosides, and organic solid phase research.

论文第一章介绍了咪唑环、噻唑环、四氮唑环等杂环的合成，总结了糖苷的合成方法，对杂环的固相合成化学进行了简单介绍。

Objective To study the efficacies of quadruple regimens for thetreatment of peptic ulcer disease and eradication of Helicobacter pylori.Methods 102patients with Hp associated peptic ulcer were randomly divided into three groups,groupA（n=98）received sanjiuweitai-based quadruple regimen（Yangweishul.2g,bid+ranitidine150mg,bid+amoxicillin500mg,bid+metronidazole400mg,bid）;group B（n=31）received colloidal bisˉmuth subcitrate110mg,bid+ranitidine150mg,bid+amoxicillin500mg,bid+metronidazole400mg,bid;groupC（n=23）received ranitidine150mg,bid+amoxicillin500mg,bid+metronidazole400mg,bid.Antibiotics were griven for two weeks,the other drugs were given for six weeks,the efficacies were determined by gastroendoscopy or 13 C—UBT.

目的 探讨四联疗法对消化性溃疡的治疗作用及根除幽门螺杆菌的效果方法将102例胃镜证实消化性溃疡者随机分为3组，A组48例给予养胃舒1.2g+雷尼替丁150mg+阿膜西林500mg+甲硝唑400mg，bid；B组31例给予铋剂220mg+雷尼替丁150mg+阿莫西林500mg+甲硝唑400mg，bid；对照组（C组，23例）给予雷尼替丁150mg+阿莫西林500mg+甲硝唑400mg，bid；以上药物除抗菌药物只服用2周外，其余药物服至6周末疗程结束，第7周复查胃镜和 13 C呼气试验。

Author had started the research on design and synthesis of heterocycles several years ago, mainly focused on the design and synthesis of imidazole, thiazole, tetrazole derivatives and their glucosides, in which most of them may have some particular bioactivities.

本论文主要是围绕具有生理活性含氮杂环化合物的设计与合成而展开的，在论文工作中我们应用液相"一锅法"和固相组合化学方法进行了咪唑环、噻唑环、四氮唑环等具有生理活性的杂环化合物及其糖苷的合成。

The reactivities of 1 and other long chain oximes with p nitrophenyl diphenyl phosphate, p nitrophenyl diethyl thiophosphate, and O ethyl ( s β diisopropylaminoethyl) methyl phosphonothiolate were studied.

报道了一种新的高亲核长链咪唑肟N 十四烷基咪唑 2 甲醛肟的设计与合成，并比较了它及其他长链咪唑肟与有机磷酸酯二苯基、对硝基苯基磷酸酯、对硫磷及 Vx 的反应活性。

Bis-imidazoline was prepared from triethylene tetraamine and N,N-dimethylformamide dimethyl acetal at 85℃ for 2 h with toluene as solvent, with a yield of 90.4%. The reaction of bis-imidazoline with 1,2-dibromoethane and potassium carbonate in acetonitrile provided with a monobromide salt yield of 78.7%. Hydrolysis of monobromide salt under aqueous causic solution formed 1,4,7,10-tetraazzcyclododecane in a 74.2% yield.

用甲苯作溶剂，使三乙烯四胺和N，N-二甲基甲酰胺二甲基缩醛在85℃反应2 h，得到中间体双咪唑啉，产率90.4%，在乙腈溶剂中，碳酸钾存在下，双咪唑啉和1，2-二溴乙烷进行扩环反应，得到环状中间体一溴盐，产率78.7%，一溴盐经碱性水解2 h，得到1，4，7，10-四氮杂十二烷，产率74.2%。

The synthesis method of the invention is as follows: first, 5-amino-2-(p-aminophenyl)- benzoxazole and aliphatic diacid are respectively recrystallized; NMP is distilled; solubilizer is dried; second, in an atmosphere of nitrogen, after Py and NMP are mixed evenly and added to a sealed reactor, the solubilizer is added into the reactor, followed by the 5-amino-2-(p-aminophenyl)- benzoxazole, then the mixture in the reactor is stirred; second, in an atmosphere of nitrogen, the mixture in the second step is stirred and heated to 50-150 DEG C, then the aliphatic diacid is added, followed by TPP for condensation; fourth, after methanol is poured into the reactor, the sediment is separated out from the mixture, filtered, washed and dried, so the semi-aromatic polyamide containing oxazole ring is obtained.

本发明的合成方法如下：一、分别重结晶5-氨基-2-苯并唑与脂肪族二酸；蒸馏NMP；干燥增溶剂；二、在氮气气氛下，Py与NMP混匀后加入密封的反应器中，再加入增溶剂，然后加入5-氨基-2-苯并唑，搅拌；三、在氮气气氛下，将步骤二的混合液搅拌并升温至50℃～150℃后加入脂肪族二酸，再加入TPP后缩聚；四、再倾入甲醇析出沉淀，过滤，清洗沉淀，再干燥；即得到含唑环半芳香聚酰胺。

N-heterocyclic compounds, such as indole, imidazole, 2-methylimidazole, 2-ethylimidazole, pyrrole and pyrrolidine, could be effectively N-methylated with DMC in the presence of 1-n-butyl-3-methylimidazolium chlorid.

吲哚、咪唑、2-甲基咪唑、2-乙基咪唑、吡咯和四氢吡咯等含氮杂环化合物在氯化1-正丁基-3-甲基咪唑的催化下能被DMC有效地N-甲基化。

Four substances including 2-methyl ethyl acetoacetate and barley straw extract distilled from bulrush as well as cetyl trimethyl ammonium bromide and isothiazo lintone were used for the comparison experiment in inhibiting the growth of Microcystis aeruginosa in various phases. Result showed that inputting chemicals in the lag phase has better effect than in the log phase, and adding in lag phase can effectively inhibit the algae growth. Although feeding allelopathic substance at log phase can lead to certain restraining effect, it cannot result in the effective inhibition of algae growth, which can be well achieved by feeding CTAB and isothiazo lintone below 10mgl/L during log phase.

研究用从芦苇中提取的2-甲基乙酰乙酸乙酯和大麦秸浸出液两种化感物质以及十六烷基溴化钱和异噻唑啉酮等四种药剂对不同生长期的铜绿微囊藻进行了对比抑制试验，结果显示在铜绿微囊藻生长的迟缓期投加试验药剂效果比在对数期投加效果都好，在迟缓期投加四种药剂，都有很好的抑藻效果；在铜绿微囊藻生长的对数期投加化感物质，虽然有一定的抑藻率，但效果较差，而在藻对数期投加10mg/L以下的CTAB和异噻唑啉酮能达到很好的水华抑制效果。

4 Kinds of methylthiazoline multithioether s were synthesized from the nucleophilic substitution of 5-methyl-thiazolidine-2-thione reacting with bromides,respectively.

通过5-甲基-2-噻唑烷硫酮与溴代物的亲核取代反应合成了四种甲基噻唑啉多头硫醚，利用红外光谱、核磁共振(1H NMR)光谱和元素分析对这四种化合物的结构进行了表征。

However, as the name（read－only memory）implies, CD disks cannot be written onorchanged in any way.

然而，正如其名字所指出的那样，CD盘不能写，也不能用任何方式改变其内容。

Galvanizes steel pallet is mainly export which suits standard packing of European Union, the North America. galvanizes steel pallet is suitable to heavy rack. Pallet surface can design plate type, corrugated and the gap form, satisfies the different requirements.

镀锌钢托盘多用于出口，替代木托盘，免薰蒸，符合欧盟、北美各国对出口货物包装材料的法令要求；喷涂钢托盘适用于重载上货架之用，托盘表面根据需要制作成平板状、波纹状及间隔形式，满足不同的使用要求。