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四唑

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Methods Compounds were isolated and purified by various column chromatographic techniques and their structures were elucidated on the basis of spectral analysis (IR, ESIMS, 1HNMR, 13CNMR). The inhibitory activity against the proliferation of HL60, REH and Raji cell lines was determined by using MTT assay.

用色谱方法分离栀子中化学成分,用波谱技术(IR,ESIMS,1HNMR,13CNMR)进行结构鉴定,用四唑盐比色法测定化合物对白血病细胞(HL60人早幼粒细胞白血病、REH人急性淋巴细胞白血病、 Raji淋巴瘤)增殖的影响。

The adipose derived stem cells of inbreds train of rat wereinduced to differentiate into schwann-like cells and the cells were injectedinto the acellular nerve allograff.The proliferation or adhersion of these cells on the graft were observed by inverted microscope or ScanningElectronic Microscope. Activity of cells were detected using MTT. 10mmnerve gap of inbreds train of rats in two group were bridged by tissue-engineered peripheral nerve or autogenous nerve, the effect wereappraised by naked eye, recovery rate of sciatic function index,nerve-electrophysiological, histology, Transmission ElectronMicroscopy and quantitative analysis of recovery rate of myelinated fiberpopulations,diameter of myelinated fiber and thickness of myelin sheat.

按照前述方法培养并诱导近交系大鼠脂肪干细胞向类Sehwann分化,将诱导分化的脂肪干细胞悬液注入已制备的去细胞同种异体神经支架管中,倒置显微镜观察细胞生长情况;扫描电镜下观察细胞在材料上附着情况;四唑盐比色试验测定细胞活性;取两组近交系大鼠,分别用组织工程化神经和自体神经桥接10mm神经缺损,通过大体观察、坐骨神经功能指数恢复率的测定、神经电生理的测定、组织学光镜观察、透射电镜观察、再生有髓神经纤维计数恢复率、神经纤维直径恢复率、髓鞘厚度恢复率的测定等指标评价实验效果。

The mechanism of thermal decomposition of tetrazole derivatives is clarified.

阐明了四唑衍生物的热解机理。

The complex 1 features a 2D tetrazole coordination polymer.

化合物1为二维四唑配位聚合物。

Tetrazole derivatives are one of the important energetic materials.

四唑衍生物是一类重要的高能材料,其金属配合物可能作为高能钝感起爆药替代叠氮化铅、它们是除叠氮化物以外研究得最为系统的起爆药剂。。。

In order to elucidate the relative magnitude of impact sensitivity of tetraozlde derivatives and their complexes and to provide valuable information for designing and synthesis of new type of safe and insensitive initiators, in the whole process we concentrate on the molecular and electronic structures, static and dynamic state properties and explosive performance of tetrazole compounds.

因为认识化合物的结构-性能关系是进行分子和材料设计的基础,所以为从分子水平上阐明四唑衍生物及其金属配合物的感度相对大小排序,从理论上指导新型安全钝感起爆剂的设计和合成,本文致力于标题物的分子结构、电子结构和静态、动态以及爆炸性质的深入研究。

Tetrazole compounds are the most extensively studied initiators apart from azides.

四唑化合物是除叠氮化物以外研究得最多的起爆药剂。

The gaseous tetrazole compounds exist mainly in the 2H-form whereas the 1H-tetrazole derivatives dominate in the condensed phase.

气相中四唑主要以2H-式存在而在极性溶剂中则相反。

They have tested the sensitivity of a series of tetrazole complexes and obtained the relative magnitude of sensitivity of a number of 5- substituted tetrazole derivatives.

但文献调研表明,整体而言,前人在该领域的实验和理论工作数量较少(多数仅为氨基和烷基四唑衍生物)、涉及面较窄、精确性较差,更缺乏系统性。

Comparisons show that there is no correlation between the experimental sensitivity of tetrazole compounds and various previously proposed theoretical static criteria, such as the bond length and bond order of relevant bonds, net atomic charges and electronegativity and the content of 2H-teterazole isomers in both gaseous and condensed states.

四唑衍生物的实验感度与前人曾提出过的各种感度理论判据—一些静态结构性质(如相关键的键长、键级、原子电荷和电负性等)以及平衡体系中2H-异构体的含量—进行比较,均未找到它们之间的规律性联系。

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