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Objective: To study the antitoxic role of vesicular monoamine transporter 2( VMAT2) in transgenic Chinese Hamster ovary cell.

目的:研究转基因中国仓鼠卵细胞中单胺囊泡转运体(VMAT2)的抗毒性作用。

In physiological conditions, dopamine is stored in synaptic vesicals, thus to avoid dopamine autoxidation and toxicology.

生理状态下,多巴胺储存于突触囊泡,从而可以避免多巴胺的自氧化损伤作用。

The effect of different additives, such as carboxylate and magnesium chlorate, etc., on the CaOxa crystal was investigated in liposomes.

讨论了不同种类羧酸盐、氯化镁和胆固醇等添加剂对囊泡中草酸钙晶体物相产生影响的机理及其作用规律。

The cysts may be large enough to be seen on cystoscopy and in gross specimens.

肉眼观,膀胱粘膜下有白黄色透明的囊泡,一般直径小于5mm,大者可达数厘米。

After that, it increases rapidly due to the disaggregation of vesicles with the increase of DSB.

在达到最低点以后,DSB继续增加,囊泡解体,重新形成DSB胶束,使得邻苯三酚的自氧化速率迅速升高。

Some individual Rab1 and Rab2 in plants have been demonstrated to function in vesicle trafficking between ER and Golgi.

植物的个别Rab1和Rab2蛋白也有研究认为与囊泡从内质网到高尔基体运输有关。

The results indicate that gramicidin S bendsat Ca of the two ornthine residues when it is bound to revetsed micelle of DPPC.

结果表明,短杆菌肽S在反向脂囊泡中不再为平面环状结构,而是有某种程度的折叠。

Four aspects of research achievements include:(1)several imaging correction methods and strained estimation methods for biological tissues elasticity imaging were investigated as well as elasticity reconstruction and phantom, in vitro and in vivo elasticity imaging experiments;(2)in the fields of biological microsystem and perfusion evaluation for microvascular system, three kinds of microbubbles whose shell are albumin, sugar ester and surfactant respectively were designed and produced, then the methods to estimate the thickness of their shells were presented, moreover, the interacting mechanism of ultrasound contrast agents and tissues, as well as protein drug delivery under the condition of ultrasound sonification were studied in the molecular level;(3) At the aspect of high intensity focused ultrasound therapy system, we designed and constructed the 256-element HIFU transducers using 1-3 composite materials. And furthermore we developed the integrated HIFU system with 256-element HIFU transducers. And we made preliminary and important progresses in the research of HIFU bioeffect, lesion estimation, techniques of monitoring and imaging and characterizing of structure of HIFU transducer;(4)The real-time method of voice source regeneration based on compensative regulation of physiological parameters was investigated in the field of medical rehabilitation. We addressed the physiology and biophysics of vocalization, modeled voice source regeneration based on compensative regulation mechanism, and put forward an integrated evaluation about the speech rehabilitation and the regenerated voice source; Sixty-one archived journal papers were published, as well as ten in international journals, and eighteen publications were embodied by SCI.

成果包括:(1)在生物组织弹性成像方面,研究了多种图像校正方法和应变估计方法,进行了弹性重构和仿体、离体及在体超声弹性成像实验研究;(2)在生物微系统和微血管血流灌注成像方面,制备了三种不同包膜超声造影微泡,研究了纳米包膜厚度检测与估计方法以及不同纳米包膜造影微泡断裂与药物释放机制,并在分子层次上开展了超声与生物组织相互作用机制以及蛋白质药物超声乳化微囊包裹的研究;(3)在阵列式高强聚焦超声治疗与监控成像技术方面,设计制作了新的HIFU换能器,解决了256阵元单焦点和多焦点合成HIFU治疗系统关键技术问题,并在HIFU生物效应与创伤性评价方法、HIFU过程监控成像技术和薄层复合结构与HIFU 换能器界面特性评价等方面的研究取得了初步而重要的进展,具有重要应用前景;(4)在语音听觉系统特别是嗓音康复方面,研究了基于发声系统补偿调节机制的实时多模式嗓音源再生方法和发声生理,建立基于神经、肌肉和空气动力系统的综合补偿调节模型,提出了相应的评价系统。

Four aspects of research achievements include:(1)several imaging correction methods and strained estimation methods for biological tissues elasticity imaging were investigated as well as elasticity reconstruction and phantom, in vitro and in vivo elasticity imaging experiments;(2)in the fields of biological microsystem and perfusion evaluation for microvascular system, three kinds of microbubbles whose shell are albumin, sugar ester and surfactant respectively were designed and produced, then the methods to estimate the thickness of their shells were presented, moreover, the interacting mechanism of ultrasound contrast agents and tissues, as well as protein drug delivery under the condition of ultrasound sonification were studied in the molecular level;(3) At the aspect of high intensity focused ultrasound therapy system, we designed and constructed the 256-element HIFU transducers using 1-3 composite materials. And furthermore we developed the integrated HIFU system with 256-element HIFU transducers. And we made preliminary and important progresses in the research of HIFU bioeffect, lesion estimation, techniques of monitoring and imaging and characterizing of structure of HIFU transducer;(4)The real-time method of voice source regeneration based on compensative regulation of physiological parameters was investigated in the field of medical rehabilitation. We addressed the physiology and biophysics of vocalization, modeled voice source regeneration based on compensative regulation mechanism, and put forward an integrated evaluation about the speech rehabilitation and the regenerated voice source; Sixty-one archived journal papers were published, as well as ten in international journals, and eighteen publications were embodied by SCI.

中文摘要:成果包括:(1)在生物组织弹性成像方面,研究了多种图像校正方法和应变估计方法,进行了弹性重构和仿体、离体及在体超声弹性成像实验研究;(2)在生物微系统和微血管血流灌注成像方面,制备了三种不同包膜超声造影微泡,研究了纳米包膜厚度检测与估计方法以及不同纳米包膜造影微泡断裂与药物释放机制,并在分子层次上开展了超声与生物组织相互作用机制以及蛋白质药物超声乳化微囊包裹的研究;(3)在阵列式高强聚焦超声治疗与监控成像技术方面,设计制作了新的HIFU换能器,解决了256阵元单焦点和多焦点合成HIFU治疗系统关键技术问题,并在HIFU生物效应与创伤性评价方法、HIFU过程监控成像技术和薄层复合结构与HIFU 换能器界面特性评价等方面的研究取得了初步而重要的进展,具有重要应用前景;(4)在语音听觉系统特别是嗓音康复方面,研究了基于发声系统补偿调节机制的实时多模式嗓音源再生方法和发声生理,建立基于神经、肌肉和空气动力系统的综合补偿调节模型,提出了相应的评价系统。

Dense cytoplasm with abundant mitochondria, endoplasmic reticulums, multivesicular bodies, vesicles and plastids were observed in normal light intensity.

在正常光照下的伴胞具有致密的细胞质,内含丰富的线粒体、内质网、多泡体、囊泡和质体,而弱光下的伴胞明显液泡化,同时含有少量的线粒体和内质网。

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According to the clear water experiment, aeration performance of the new equipment is good with high total oxygen transfer coefficient and oxygen utilization ratio.

曝气设备的动力效率在叶轮转速为120rpm~150rpm时取得最大值,此时氧利用率和充氧能力也具有较高值。

The environmental stability of that world - including its crushing pressures and icy darkness - means that some of its most famous inhabitants have survived for eons as evolutionary throwbacks, their bodies undergoing little change.

稳定的海底环境─包括能把人压扁的压力和冰冷的黑暗─意谓海底某些最知名的栖居生物已以演化返祖的样态活了万世,形体几无变化。

When I was in school, the rabbi explained everythingin the Bible two different ways.

当我上学的时候,老师解释《圣经》用两种不同的方法。