嘌呤碱基

To determine whether N6amt1 methylates adenine residues in DNA, we examined its activity by in vitro assay.

为了检测N6amt1是否能够甲基化DNA中的腺嘌呤碱基，我们运用体外酶活检测系统对它的活性进行了测定。

The modified electrode showed an attractive electrocatalytic ability and could enhance the current response of electro-active molecules by employing potassium ferricyanide, as...

在最佳条件下，应用微分脉冲伏安法检测，鸟嘌呤碱基的氧化峰电流与ssDNA的浓度在40μg·L-1-5.0mg·L-1范围内呈现良好的线性关系，检测限为5μg·L-1(S/N=3，信噪比)。

Two different lines of evidence support the view that a base pair is composed of one purine and one pyrimidine.

有两方面的证据支持在DNA分子的螺旋构型中，每一个碱基对中都含有一个嘌呤碱基和一个嘧啶碱基

What evidence do we have that in the helical form of the DNA molecule the base pairs are composed of one purine and one pyrimidine?

我们有什么证据表明在 DNA 分子的螺旋构型中，在每一个碱基对中都含有一个嘌呤碱基和一个嘧啶碱基？

The stability energy of the whole complex, and the interaction energy between two purine bases and the [Pt-(NH3)thiazole]2＋ group were adopted to study the interplay among subsystems and their contribution to relative stability of all the studied cross-link model.

本文采用化合物整体稳定化能，两个嘌呤碱基与[Pt-(NH3)thiazole]2+部分的相互作用能来研究不同部分间的相互作用及其对加合物的相对稳定性的影响。

The reaction mechanism for the formation of ultimate carcinogens diazohydroxide, diazonium and oxoniumions by α-hydroxylation-NPYR and the alkylation process of C and guanine were investigated including solvent effects at the B3LYP/6-31G(superscript **) level.

采用密度泛函理论，在B3LYP/6-31G水平上，研究了气相和水溶剂中，α-羟基化吡咯烷亚硝胺(-αhydroxylation-NPYR， A)代谢为终致癌物重氮氢氧化物、重氮烷阳离子和氧离子，以及C与鸟嘌呤碱基相互作用的反应机理。

The famciclovir was synthesized from purine by a series of steps by Acylation, Decarboxylation, Reduction ,and so on; Derivatives of these intermediates is described from the 6-chloro- 9H- purin-2-amine as raw materials in different conditions when the iodine and bromide were synthesized with the addition of two intermediate 6-bromo-9H-purin-2-amine and 6-iodo-9H-purin-2-amine; There is elaborated from the main part of a acetophenone, urineaminohydrochloride, phenylhydrazine, ethyl acetoacetate as raw material through a series of reactions to synthetic 3-phenyl-4-formylphenyl pyrazole and 5-chloro-3-methyl-1-phenyl-1H-pyrazole-4-aldehyde two pyrazole aldehyde, and then with 2-amino-6-chlorine-9-(2-methicillin-oxo-co-methyl-4-yl) purine reaction of the two new pyrazole purine Schiff bases.

本论文主是采用以鸟嘌呤为原料，经过一系列的酰基化，脱羧，还原等反应作用下最终得到了产物2-氨基-9-(4-乙酰氧基-3-乙酰氧基甲基丁基)嘌呤；其中的中间体衍生物主要是阐述从以2-氨基-6-氯鸟嘌呤为原料通过在不同的条件下进行溴代与碘代分别合成了另外两种中间体2-氨基-6-溴鸟嘌呤及2-氨基-6-碘鸟嘌呤；还有一部分主要是阐述从以苯乙酮，盐酸氨基脲，苯肼，乙酰乙酸乙酯为原料通过一系列的反应先合成3-苯基-4-醛基吡唑及5-氯-3-甲基-1-苯基-1H-吡唑-4-甲醛这两个吡唑醛，然后再与2-氨基-6-氯-9-(2-甲氧羰基丁酸甲酯-4-基)嘌呤反应得到了两个新型的吡唑嘌呤席夫碱

On the discussion about mechanism of mutation of methylating, we explored thermodynamics and dynamic properties on base pairs, investigating the proton transfer on base pairs.

从甲基化对嘌呤碱基电荷的影响，到甲基化引起碱基配对的改变造成碱基配对的诱变等都作了较为详细的探讨；在对甲基化诱变的探讨中，我们进行了热力学和动力学方面的研究，同时对碱基之间的质子迁移的难易程度也作了探讨；并在充分考虑水分子存在的情况下研究了甲基化对碱基之间的氢键作用和堆积作用的影响。

Electron transfer reaction between the radical cations of purine nucleotides and some aromatic amino acids was studied by use of pulse radiolytic techniques. Time-resolved spectroscopic evidence revealed that the one-electron-oxidized radicals of dAMP and dGMP can be efficiently repaired by tyrosine and tryptophan.

鉴于在DNA光敏损伤过程中主要生成嘌呤碱基阳离子自由基，利用脉冲辐解技术研究了嘌呤碱基阳离子自由基与部分芳香氨基酸的相互作用，获得了酪氨酸和色氨酸对单电子氧化的dAMP和dGMP经快速电子转移修复的瞬态吸收光谱证据。

The removal of a purine base from the DNA backbone.

从DNA骨架上去除嘌呤碱基的过程。

With Death guitarist Schuldiner adopting vocal duties, the band made a major impact on the scene.

随着死亡的吉他手Schuldiner接受主唱的职务，乐队在现实中树立了重要的影响。

But he could still end up breakfasting on Swiss-government issue muesli because all six are accused of nicking around 45 million pounds they should have paid to FIFA.

不过他最后仍有可能沦为瑞士政府&议事餐桌&上的一道早餐，因为这所有六个人都被指控把本应支付给国际足联的大约4500万英镑骗了个精光。