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DNA methylating inhibitor makes the transfer of the methyl group to adenine or cytosine impossible,thus the reaction of DNA methylation is inhibited,the genomic methylation level is decreased.

DNA甲基化抑制剂使甲基基团不能转移到腺嘌呤或胞嘧啶，导致DNA甲基化反应受阻，从而使基因组甲基化水平降低。

The shorter variant mHemk2 is 1696 bp in length encoding a putative mouse protein of 14.7 kDa, consisting of 138 amino acid residues.In protein data bank annotations, Hemk has previously been classed among methyltransferases methylating N6-adenine or N4-cytidine in DNA because of the presence of S-adenosyl-L-methionine binding motif and of an NPPY motif in the protein.

在蛋白数据库的注释中，由于在Hemk蛋白中存在S-腺苷-L-甲硫氨酸结合基序和一个NPPY基序，因此，在蛋白库的说明中已经将Hemk蛋白归类于能甲基化DNA中N6-腺嘌呤或N4-胞嘧啶的甲基转移酶。

Our study includes four aspects. In the first aspect we study several important conditions of porcine oocytes maturation in vitro and oocytes cleavage after parthenogenetic activation and found mNCSU-23+15IU/mlPMSG+20IU/mlHCG+15% PFF+0.57mMcysteine is a good culture condition .When the Cocs are cultured in it ,the maturation rate and oocytes cleavage rate are higher than those of foreign covered. Our result are (86.7±3.35)% and (86.3±4.16)% and the highest report of foreign is(85.7±4.1)%.In the second aspect we study the effect of different chemical activations on development of porcine parthennogenetic embryo and found two best activation method. The first one is that putting the maturation MII oocytes in the 20μmol/L ionomycin for 30 minutes and then putting them in the NCSU-23 condition containing 5μg/mICB and 5mM/L6-DMAP for 3.5 hours, the oocytes cleavage rate and morulae/blastocysts development rate are (76.7±7.6)% and (37.1±6.4)%.The second one is that putting the maturation MII oocytes in the 200μM/L Thimerosal for 20 minutes and then putting them in the NCSU-23 condition containing 8mM DTT for 30 minutes

本研究分为4个部分，第一部分对影响猪卵母细胞体外成熟和孤雌激活后胚胎分裂的几个重要条件进行了比较研究，确立了一种较好的培养方法：与颗粒细胞共培养，找到了一种适合猪卵母细胞体外成熟的培养基：mNCSU-23+15IU/mlPMSG+20IU/mlHCG+15%PFF+0.57mM半胱氨酸，成熟率和分裂率分别为(86.7±3.35)%和(86.3±4.16)%，国外报道的最高成熟率为(85.7±4.1)%；第二部分对猪卵母细胞孤雌激活的化学方法进行了研究，确立了化学激活猪卵母细胞的两种最佳方法：1将成熟的去卵丘颗粒细胞的MII期卵母细胞用20μmol/Lionomycin作用30min，再将卵母细胞培养于含5μg/mlCB和5mM/L 6-DMAP(6-二甲基氨基嘌呤)的NCSU-23培养液中，卵裂率和桑囊胚发育率达到(76.7±7.6)%和(37.1±6.4)%2将成熟的去卵丘颗粒细胞的MII期卵母细胞在200μM/L的Thimerosal中处理20min，再与8mM的DTT共孵育30min，卵裂率和桑/囊胚形成率为(81.0±2.8)%和(39.6±2.7)%；第三部分对孤雌激活胚胎的培养条件进行了研究，确立了一种最佳的胚胎培养条件：在SOF简单培养基中添加颗粒细胞进行前3天的培养，然后转入添加胎牛血清的NCSU—23培养基并和输卵管上皮细胞进行后期的培养，其桑椹胚和囊胚的发育率为(59.5±3.2)%；第四部分研究了IGF-I

Taking Eremothecium ashbyii (abbreviated as Eaw95. 1) as the original strain, after Υ-ray mutation, tubercidin and 8--azaguaniae (8--AG) resistant tests, a strain labeled as T〓 capable of overproducing riboflavin was obtained and its genetic stability was analyzed. Compared with Eaw95. 1, the riboflavin productivity was improved about 40% by flask--shaking tests.

以Eremothecium ashbyii为出发菌（间称Eaw95.1），通过Υ-射线诱变，杀结核菌素和8-氮杂鸟嘌呤等结构类似物的的抗性筛选，获得了一株核黄素高产菌T〓，并对菌株的遗传稳定性进行了研究，获得了较好的效果，与出发菌株相比，核黄素的摇瓶发酵产量提高了近40％。

In one model, the DNA cooperatively unwinds, while base pairing remains intact.

这组科学家指出，拉伸最初可能始于腺嘌呤和胸腺嘧啶丰富的区域，而且双链DNA需要一个最低程度的力量才能开始分解。

Objective To investigate the effect of marine collagen peptides on adenineinduced chronic renal function impairment in rats.

目的研究海洋胶原肽对腺嘌呤所致大鼠慢性肾功能损伤的影响。

Three kinds of fluorescence polymer with the structure of acridine yellow were synthesized and the sensor for measuring nucleic acid was also fabricated.

论文第三部分开展了以荧光高分子为敏感试剂的新型光化学传感器载体研究，合成了N，N-二甲氨基对苯甲醛缩醛类聚合物，考察了苯环上不同取代基对荧光性能的影响，研究了该类敏感膜对乳酸、尿嘧啶、胸腺嘧啶和腺嘌呤的响应性能；合成了三种具有吖啶黄结构的荧光高分子，制成了测定核酸的传感器。

Six crossbred steers (Simmental×Indigenous yellow cattle) with cannulas in rumen,duodenum and terminal ileum are used for determining the effects of feeding level on synthesis efficiency of rumen microbial protein.

用6头装有瘤胃、十二指肠、回肠瘘管的西门塔尔杂交阉牛，以Cr2O3为指示剂测定食糜流量，用嘌呤氧化法测定RNA当量，研究不同饲养水平下，西门塔尔杂交阉牛瘤胃微生物蛋白的合成效率。

Vitamins and coenzymes are synthesized in various pathways that leave central metabolism ,ATP and DNA are part of purine metabolism .

维他命和辅酵素被综合以留下中央新陈代谢，并且DNA 是嘌呤的各种各样的路新陈代谢的一部分。

Cytokinins are produced in roots, where they stimulate cell division.

天然的细胞分裂素是腺嘌呤的衍生物。

With Death guitarist Schuldiner adopting vocal duties, the band made a major impact on the scene.

随着死亡的吉他手Schuldiner接受主唱的职务，乐队在现实中树立了重要的影响。

But he could still end up breakfasting on Swiss-government issue muesli because all six are accused of nicking around 45 million pounds they should have paid to FIFA.

不过他最后仍有可能沦为瑞士政府&议事餐桌&上的一道早餐，因为这所有六个人都被指控把本应支付给国际足联的大约4500万英镑骗了个精光。