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Previously we found that ARNA response was impaired in rat nephropathies of puromycin aminonucleoside, lipopolysaccharide, or cyclosporine A, and these sensory defects were ameliorated in rats pretreated with hypoxia preconditioning. However, the underlying mechanisms are not clear.

依据本实验室之前研究，在许多肾病变中，包括：嘌呤霉素核苷酸（puromycin aminonucleoside， PAN）、内毒素（lipopolysaccharide， LPS）、以及环孢菌素A（cyclosporine A， CsA）所引起的肾病变中，都观察到肾脏感觉功能失调的现象，而且本实验室之前的研究也发现低氧预处理能够减缓这些疾病中肾感觉功能失调的现象。

Methods 26 cases were treated by oral administration of amlodipine 5 mg, berberine 0.3g, meanwhile treated the acute arthrolithiasis by oral administration of colchicine 0.5mg, reated hypertensive with chronic gout by oral administration of allopurinol 100mg.

方法选择轻、中度老年高血压患者26例，给予患者口服氨氯地平5mg，1次/d，小檗碱0.3g，3次/d，同时给予急性痛风患者，口服秋水仙碱0.5mg，慢性痛风患者，口服别嘌呤醇100mg。

objectiveto investigate the efficacy and safety of amlodipine with berberine in the treatment of mild and moderate hypertensive with arthrolithiasis.methods 26 cases were treated by oral administration of amlodipine 5 mg, berberine 0.3g, meanwhile treated the acute arthrolithiasis by oral administration of colchicine 0.5mg, reated hypertensive with chronic gout by oral administration of allopurinol 100mg.

目的评价氨氯地平联用小檗碱治疗轻、中度老年高血压合并痛风患者的降压疗效。方法选择轻、中度老年高血压患者26例，给予患者口服氨氯地平5mg，1次/d，小檗碱0.3g，3次/d，同时给予急性痛风患者，口服秋水仙碱0.5mg，慢性痛风患者，口服别嘌呤醇100mg。

AIM: To determine the distribution and frequency of functionally important allelic variants in the cytochromes P450 2C19, arylamine N-acetyltransferase 2 (NAT2), and thiopurine S-methyltransferase genes in the Han Chinese population and compare them with those of other ethnic populations.

目的： 了解细胞色素P450(cytochromes P450，CYP)2C19，N-乙酰基转移酶2(arylamine N-acetyltransferase 2，NAT2)和硫嘌呤甲基转移酶(thiopurine S-methyltransferase，TPMT)基因常见的遗传多态性在河南地区汉族人群中的分布及其频率。

As barbituric acid and riboflavin was respectively added into PC/4 coliposomal solution, the absorbivity of barbituric acid at 258 nm, and riboflavin at 222 nm and 264 nm decreased slowly with time. The onset of a hypochromic effect can be ascribed to adeninebarbituric acid or riboflavin interaction.

紫外可见光谱研究表明，底物巴比妥酸在258 nm的吸收峰，核黄素在222 am，264 nm的吸收峰随时间的延长而逐渐降低，这种减色作用归因于脂质体内的巴比妥酸和核黄素在亲脂区分别与双亲化合物上的腺嘌呤形成了氢键。

The regulation effects of 6 benzylaminopurine (BA, 0.05g/L) and ethyrel (ETH, 0.5g/L) on export of carbo assimilates from wheat leaf and its partition in the whole plant were studied using 14 CO 2 labeling method.

在盆栽条件下，采用活体测量和定期取样测定的方法，研究了6苄氨基嘌呤和乙烯利处理对小麦幼苗第1茎生叶14C同化物输出动态和向各器官中分配的影响。

To study the changes between SOD activity and LPO content in serum of the patients with cholecystolithiasis before and after operation, the methods of xanthine oxidase and thiobarbituric acid were applied to this study.

为研究胆囊结石患者血清中超氧化物岐化酶活性水平、过氧化脂质含量及其变化规律，应用黄嘌呤氧化酶法和硫代巴比妥酸法测定了48例胆囊结石患者手术前后血清中SOD活性和LPO含量。

Our main products include 5-Methyl-2-pyrazinecarboxylic acid series, Guanine series, Folic acid series, Methyl Cyanoacetate and Ethyl cyanoacetate series, we also have made great contribution in the development of cardiovascular drug, stomach drug, anti-inflammatory drug and antidepressants, such as Nizatidine, Acipimox, Glipizide, Zaltoprofen and Pregabalin, which have been put into production on large scare.

公司主要产品有5-甲基吡嗪-2-羧酸系列，鸟嘌呤系列，叶酸，氰乙酸甲酯，氰乙酸乙酯系列，在心血管药、胃药、消炎药、抗抑郁药等新品开发上有重大建树，先后研制成功，形成批量生产，如尼扎替丁、阿西莫斯、格列吡嗪、扎托洛芬、普瑞巴林，同时具备为客户定制化学品的能力。

The reaction mechanism for the formation of ultimate carcinogens diazohydroxide, diazonium and oxoniumions by α-hydroxylation-NPYR and the alkylation process of C and guanine were investigated including solvent effects at the B3LYP/6-31G(superscript **) level.

采用密度泛函理论，在B3LYP/6-31G水平上，研究了气相和水溶剂中，α-羟基化吡咯烷亚硝胺(-αhydroxylation-NPYR， A)代谢为终致癌物重氮氢氧化物、重氮烷阳离子和氧离子，以及C与鸟嘌呤碱基相互作用的反应机理。

Furthermore, seven compounds were isolated from CSPD and their chemical structures were authenticated by spectral analysis as tetrandrine, fangchinoline, tetrandrine-2′- N-β-oxide, tetrandrine-2′- N-α-oxide, dicentrine, dicentrinone, and adenine, respectively.

从粉防己专属性对照物质中分得粉防己碱、防己诺林碱、tetrandrine-2′- N-β-oxide，tetrandrine-2′- N-α-oxide，荷包牡丹碱、荷包牡丹酮和腺嘌呤等7个成分，经波谱分析鉴定了结构。

It has been put forward that there exists single Ball point and double Ball points on the symmetrical connecting-rod curves of equilateral mechanisms.

从鲍尔点的形成原理出发，分析对称连杆曲线上鲍尔点的产生条件，提出等边机构的对称连杆曲线上有单鲍尔点和双鲍尔点。

The factory affiliated to the Group primarily manufactures multiple-purpose pincers, baking kits, knives, scissors, kitchenware, gardening tools and beauty care kits as well as other hardware tools, the annual production value of which reaches US$ 30 million dollars.

集团所属工厂主要生产多用钳、烤具、刀具、剪刀、厨具、花园工具、美容套等五金产品，年生产总值3000万美元，产品价廉物美、选料上乘、质量保证，深受国内外客户的青睐