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嗜铬细胞

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Results Multifocal pheochromocytoma comprised of 14.1% of the total pheochromocytoma treated in the same period.

结果 多发性嗜铬细胞瘤占同期嗜铬细胞瘤的14.1%(17/121)。

By contrast, dexamethasone, a synthetic glucocorticoid, induces a chromaffin cell phenotype characterized by increased cell flattening, loss of neuritic processes, increased chromogranin A and tyrosine hydroxylase proteins, and decreased amounts of secretogranin II and neurofilaments.

作为对照,地塞米松诱导嗜铬细胞表型,具有特征的增加细胞变扁、丧失神经突起,增加嗜铬粒蛋白A和酪氨酸羟化酶蛋白,减少分泌粒蛋白II和神经丝的数量。

These experiments suggest that this dihydropyridinesensitive isoform of the mbC α1 subunit is functional in the transfected chromaffin cells and that the number of calcium channels is a limiting component in the secretion from chromaffin cells in culture.

这些实验结果推论这个小鼠脑中的对双氢吡啶敏感的mbC钙离子通道是L-型钙离子通道,并在转化的肾上腺嗜铬细胞中具有功能活性,而且说明钙离子通道的数目对培养的肾上腺嗜铬细胞的分泌是个限制因素。

This pheochromocytoma demonstrates the chromaffin reaction. This neoplasm of the adrenal medulla contains catecholamines.

嗜铬细胞瘤显示嗜铬反应阳性,该肾上腺髓质肿瘤含有儿茶酚胺(肾上腺素和去甲肾上腺素)。

Abstract] Pheochromocytomas are rare but clinically important chromaffin cell tumors that typically arise from the adrenal gland and constitute a surgically correctable cause of chronic hypertension.

摘要]嗜铬细胞瘤是主要来源于肾上腺的一种少见的,但又是临床上很重要的嗜铬细胞的肿瘤,它也是用外科手术可以治愈的一种慢性高血压。

The expression of NSE was detected in cortex of adrenal cortical hyperplasia, cortical adenomas and pheochromoeyte carcinoma, hut not in that of pheochromocytoma and normal adrenal. The expression of SYN was detected in cortex of corticohyperplassia, cortical adenomas, medull neoplasm, chromophile tumor and pheochromocyte carcinoma, but not in that of cortical adenocarcinoma and normal adrenal. The expressions of CgA, NSE and SIN were detected in the medulla of all cases. Conclusion The characteristic of CgA, SYN and NSE in cortex and medulla of adrenal are useful in the differential diagnosis of tumor and hyperplasia in the adrenal.

结果 肾上腺皮质腺瘤、皮质腺癌、嗜铬细胞瘤和嗜铬细胞癌的皮质中均可见CgA染色阳性细胞,皮质增生、髓质增生和正常肾上腺病例皮质CgA染色阴性;肾上腺皮质增生、皮质腺瘤、皮质腺癌、髓质增生和嗜铬细胞癌NSE染色呈阳性,嗜铬细胞瘤和正常肾上腺皮质NSE染色呈阴性;皮质增生、皮质腺瘤、髓质增生、嗜铬细胞瘤和嗜铬细胞癌的皮质中SYN染色呈阳性,皮质腺癌和正常肾上腺皮质SYN染色呈阴性;所有病例髓质CgA、NSE和SYN染色均呈强阳性。

The term composite pheochromocytoma has been used for pheochromocytomas with a component of neuroblastoma, ganglioneuroblastoma, ganglioneuroma, or malignant peripheral nere sheath tumor.

复合嗜铬细胞瘤主要是指具有成神经细胞瘤、成神经节细胞瘤、神经节瘤或恶性周围神经鞘膜瘤成分的嗜铬细胞瘤。

The key points of diagnosis of pheochromocytoma were concluded as follow: a history ofparoxymal hypertension;an increased concentration of plasma catecholamines;131I-MIBG was a high sensitive and specific method with qualitative and orientative value.

综合本组病例的临床资料,诊断嗜铬细胞瘤的要点有:(1)病史中存在阵发性高血压的线索;(2)血中儿茶酚胺浓度增高;(3)131I-MIBG对诊断嗜铬细胞瘤具有高的敏感性和特异性,并兼有定位及定性诊断价值。

Objective To study the relationship between the expression of Neuropeptide Y and vasocative intestinal peptide in adrenals and adrenal Pheochromocytoma.

【目的 探讨神经肽Y (Neuropeptide Y, NPY)和血管活性肠肽( vasocative intestinal peptide, VIP)在肾上腺嗜铬细胞瘤组织中的表达与肾上腺嗜铬细胞瘤的关系。

VEGF positive stainings of endothelialcells and tumor cells were higher in pheochromocytomas than those in normalcontrols.

1。建立了人嗜铬细胞瘤细胞的原代培养方法,并证明其具有嗜铬细胞瘤的分泌和表达功能。2。

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