嗅脑

The potential AD patients showed more significant impairment in olfactory function (the average value of DT and RT were respectively 1.970±0.903 and 3.081±0.474) than the controls (the average value of DT and RT were respectively 1.468±0.933 and 2.542±0.748), some of the potential AD patients were anosmia; The DT average value of the controls were significantly lower than the potential AD patients't=2.166, p

本研究中发现可能AD 患者嗅粘膜有与AD 脑内病理改变相关的神经丝堆积，可将其作为研究AD 活的神经细胞的来源。因此怎样不断完善和改进嗅觉检查方法，以进一步提高其早期拟诊AD 的敏感性和特异性，将具有广阔的科研前景和重要的临床应用价值。

In adult brain, Xvax2 was expressed in ventral region of telencephalon and diencephalon, which contains olfactory bulb, hippocampus, optic chiasma, optic tract and hypothalamus.

Xvax2在成体脑中的分布仍局限于端脑和间脑腹侧，其表达区域主要包括嗅球、端脑侧脑室腹侧的海马区域，以及视交叉、视束初始段和下丘脑边缘。

In the brain of adult rat, the positive immunohistochemical product of lSL-l (ISL-l-positive) was mainly located in the neuronal nucleus and found in discrete regions except to brain cortex, such as the Purkinje cell layer and the granular cell layer of cerebellum, the granular cell layer and the pyramidal cell layer of hippocampus, the mitral cell layer, the internal and external plexiform layer, the granular cell layer and the granular cell layer of olfactory bulb and so on, and several nuclei of the hypothalamus, midbrain and pons, such as claustrum, anterior olfactory nucleus, accumbens nucleus, caudate-ptamen, pallidum, substantia nigra, striatum, islands of Callaje, mammillary nucleus, anterior pretactal nucleus, habenular nucleus, amygdaloid nucleus, cuneate nucleus, rubral nucleus, gigantocellular reticular nucleus and so on.

在正常成年大鼠脑中，同源框基因islet-1表达产物（ISL-1）免疫组织化学阳性物质广泛分布于除大脑皮层外的神经细胞的细胞核内，ISL-1阳性神经元密集分布于小脑Purkinje细胞层和颗粒细胞层、海马的颗粒细胞层和锥体细胞层、嗅球的内丛层、外丛层、颗粒细胞层及僧帽细胞层等，另外在丘脑、中脑和桥脑的一些重要神经元核团均有分布，如，屏状核、前嗅核、伏核、尾壳核、苍白球、黑质、纹状体、Calleja岛、乳头体核、前顶盖前核、缰核、杏仁核、楔束核、红核网状巨细胞核等。

In addition to glial cells, CNTF immunoreactivity are widely localized at neurons in the olfactory bulb, cortex, hippocampus, cerebellum, diencephalon and brainstem.

结果表明，CNTF免疫反应物质除广泛存在于中枢神经系统的胶质细胞外，亦有神经元的广泛染色，而且分布广泛，在嗅脑、大脑皮层、海马、小脑、间脑、脑干中均有明显的染色。

The activity of Cre recombinase is predominantly detected in the midbrain, diencephalon and olfactory bulb in the SCC4.4-iCre transgenic brain. However, it only can be observed in the caudal part of the midbrain in the SCC2.7-iCre brains. The results suggest that CYP11A1 gene expression could be differentially regulated in different regions of the brain.

结果发现，4.4 kb与2.7 kb之CYP11A1启动子皆可使Cre重组酶表现於胚胎脑部，前者主要表现在中脑、间脑及嗅球，后者仅主要表现在中脑尾端，说明了CYP11A1在不同脑区表现所需的元素有所不同，可能有不同的调控机制。

To develop a method for the culture of OECs and to evaluate the therapeutic effect of OECs transplantation on experimental allergic encephalomyelitis.

目的 研究嗅鞘细胞的培养及其对实验性变态反应性脑脊髓炎的治疗功用。

Mushroom bodies and antennal lobes in Oxycetonia jucunda were conspicuous. Calyces and lobes of the mushroom bodies.were much developed. In contrast, calyces of Ambrostoma quadriimpressum and Henosepilachna vigintioctomaculata were extremely undeveloped. However, the postretinal fibres and circumpharyngeal nerves of Ambrostoma quadriimpressum were highly developed. In the three beetles, 5-HT immunoreactivity was present in all neuropils of the brain and the suboesophageal ganglion. The pattern of 5-HT immunoreactivity and the localization of immunoreactive somata which often clustered into groups were similar among these beetles, while the immunoreactivity intensity was distinct, especially in the lamina.

结果显示，分类地位相近的三种甲虫脑结构大小相差悬殊：小青花金龟脑结构相对发达，蕈形体结构显著，具有发达的冠和叶，嗅叶发达；马铃薯瓢虫和榆紫叶甲的冠极度退化，嗅叶相对不发达；但榆紫叶甲具有十分发达的网膜后纤维和围咽神经。5-HT阳性纤维在三种甲虫的所有神经纤维网中几乎都有分布，且反应模式相似，但各神经纤维网特别是神经节层染色强度差异显著。5-HT阳性胞体有成群分布现象，且在三种甲虫脑中的空间分布位置基本一致。

HVc received projections from medial nucleus magnocellularis of the anterior neostriatum,nucleus interfacialis of midneostriatum,telencephalie auditory nucleus-field L,nucleus uvaeformis of the thalamus,and locus ceruleus of the pons.

投射到古纹状体粗核和嗅叶X区，HVc接受新纹状体前部大细胞核内侧部、新纹状体中部界面核、端脑听核一L区、丘脑葡萄形核及脑桥蓝斑核的传入投射。

Part 4: Brain-derived neurotropic factor genetically modified olfactory ensheathing cells of the neonatal rat Objective To culture the olfactory ensheathing cells from the neonatal rat and modify them genetically by human Brain-derived neurotropic factor to increase the formation of neurophic factors. Methods The OECs were dissociated from the neonatal rat olfactory bulbs and purified with time-speed difference stick.

第四部分：脑源性神经营养因子基因转染新生大鼠嗅鞘细胞目的为提高嗅鞘细胞(Olfactory ensheathing cells，OECs)分泌脑源性神经营养因子(BDNF，Brain-derived neurotropic factor)的能力，探讨将外源性BDNF基因转染入OECs，为今后采用BDNF基因修饰的OECs移植治疗SCI奠定基础。

The distribution pattern of mGnRH in the brain during regressed stage was similar to that during recrudescing stage.

退化期和再发育期蛙脑中mGnRH的分布规律基本相同：即端脑-嗅球、视前-交叉区、下丘脑-正中隆起的mGnRH含量彼此相近；而上丘脑-中脑及小脑-延脑的mGnRH含量为0。

As she looked at Warrington's manly face, and dark, melancholy eyes, she had settled in her mind that he must have been the victim of an unhappy attachment.

每逢看到沃林顿那刚毅的脸，那乌黑、忧郁的眼睛，她便会相信，他一定作过不幸的爱情的受害者。

Maybe they'll disappear into a pothole.

也许他们将在壶穴里消失