喹诺酮

Results: The clinical manifestations of paratyphoid A included: fever, normal or count decline of white blood cell and blood eosinophilic granulocyte, half of the patients had rising aminotransferase and were sensitive to diverse antibiotics, especially to fluoquinolones, aminoglycoside, the third generation of cephalosporins and Chloromycetin, the sensitive rates of them were higher than 90%, among them, the sensitive rates of Lavo-Ofloxacin, Butikacin, Gentamicin and Ceftazidime were 100%. Average course of treatment and defervesce was 10 and 5.4 days respectively.

结果：89例患者均有发热，血白细胞正常或减少，嗜酸粒细胞减少，50%有转氨酶升高、对多种抗生素高度敏感，尤其喹诺酮类、氨基糖苷类、头孢三代(头孢他啶、头孢曲松、头孢噻肟)及氯霉素敏感率大于90%，其中，左氧氟沙星、阿米卡星、庆大霉素、头孢他啶敏感率为100%，平均疗程10 d，平均退热时间5.4 d。

Patients with paratyphoid A show fever, sensitive to diverse antibiotics. Considering drug side-effect, healing effect and cost, fluoroquinolones is first choice and cephalo-type is second choice, both of them can combine when complicated with pneumonia.

甲型副伤寒以发热为主，对多种药物敏感，考虑药物副作用、疗效、费用等因素，建议首选喹诺酮类，次选头孢类，合并肺部感染者可二者联用。

The clinical performance for 102 cases of patients suffered from paratyphoid show versatile.

102例甲型副伤寒的临床表现多样，针对甲型副伤寒杆菌出现多重耐药，采取第三代喹诺酮联合第三代头孢类治疗，取得较好的疗效。

ObjectiveTo study the relationship between fluoroquinolone resistance in Neisseria gonorrhoeae and mutations in gyrA and/or parC genes.

目的研究淋病奈瑟球菌耐氟喹诺酮类药物与gyrA和parC基因突变的相关性。

The mutations in the quinolone resistance-determining regions of the gyrA and parC genes were analyzed by PCR and sequencing.

PCR扩增gyrA和parC基因的喹诺酮耐药决定区，扩增的片段长度分别为525bP和487bp， PCR产物直接测序。

Synthesis,crystal structure of norfloxacin picrate supramolecular compound and study on the interaction between norfloxacin picrate and DNA.

因此，在Cu~(2+)存在下，各喹诺酮分子紫外吸收光谱仍随DNA的增加而减小，且减小幅度较大。

Objective To study the mechanism of quinolone resistance in Pseudomonas aeruginosa.

目的研究30株铜绿假单胞菌对喹诺酮类药物的耐药机制。

This experiment analyzes the function mechanism of this medicine in terms of microcosmic, it has something in common to combine the mode and other quinoline promise ketone medicines, but combine parameter value of different size.

本实验从微观的角度分析该药物的作用机制，其结合模式与其他的喹诺酮类药物有相同之处，但结合参数值大小不同。

The result shows: at different temperatures the outcomings obtained in determining dissociation constants with such two theories can be seen effective, but the doubly reciprocal curves of quenching equation are not conformed to quenching curves based on dynamic and static quenching mechanism as those of fluorescence enhancement.

通过荧光和紫外方法研究盐酸左氧氟沙星、氟罗沙星、加替沙星和沃氟沙星四种喹诺酮类药物与人血清白蛋白的作用，在不同温度下对荧光加强和猝灭理论公式的等价性和精细差异进行了比较，结果表明：在不同温度下两种理论公式尽管在求取解离常数上所得结果都可视为有效，但猝灭方程的双倒数图反而不及荧光加强方程的双倒数图与体现动态、静态猝灭机理的猝灭曲线一致。

This method is used to determine the content of quinolones compounds in human serum with satisfactory results.

该方法用于测定血清样品中喹诺酮类药物的含量，获得满意的实验结果。

According to the clear water experiment, aeration performance of the new equipment is good with high total oxygen transfer coefficient and oxygen utilization ratio.

曝气设备的动力效率在叶轮转速为120rpm～150rpm时取得最大值，此时氧利用率和充氧能力也具有较高值。

The environmental stability of that world - including its crushing pressures and icy darkness - means that some of its most famous inhabitants have survived for eons as evolutionary throwbacks, their bodies undergoing little change.

稳定的海底环境─包括能把人压扁的压力和冰冷的黑暗─意谓海底某些最知名的栖居生物已以演化返祖的样态活了万世，形体几无变化。