唑

The results showed that the decomposition of 4-nitroimidazole began with the split of the C—NO2 bond in the temperature range of 185—210℃. The strongly oxidative product NO2 destroyed the instable annulus of 4-nitroimidazole instantly, all the other C＝N, C＝C, C—H and N—H bonds of the five membered ring were broken simultaneously, and the detected gas products of 4-nitroimidazole decomposition were NO2, CO2 and CO.

结果表明，4-硝基咪唑的催化热分解起始于其分子中C-NO2化学键的断裂，温度范围是185~210℃。C-NO2键的强氧化性的裂解产物NO2瞬间作用于4-硝基咪唑分子中不稳定的五员环，使化学键C=N、C=C、C-H和N-H同时被打破。4-硝基咪唑的气体分解产物包括NO2、CO2和CO。

Objective To study the efficacies of quadruple regimens for thetreatment of peptic ulcer disease and eradication of Helicobacter pylori.Methods 102patients with Hp associated peptic ulcer were randomly divided into three groups,groupA（n=98）received sanjiuweitai-based quadruple regimen（Yangweishul.2g,bid+ranitidine150mg,bid+amoxicillin500mg,bid+metronidazole400mg,bid）;group B（n=31）received colloidal bisˉmuth subcitrate110mg,bid+ranitidine150mg,bid+amoxicillin500mg,bid+metronidazole400mg,bid;groupC（n=23）received ranitidine150mg,bid+amoxicillin500mg,bid+metronidazole400mg,bid.Antibiotics were griven for two weeks,the other drugs were given for six weeks,the efficacies were determined by gastroendoscopy or 13 C—UBT.

目的 探讨四联疗法对消化性溃疡的治疗作用及根除幽门螺杆菌的效果方法将102例胃镜证实消化性溃疡者随机分为3组，A组48例给予养胃舒1.2g+雷尼替丁150mg+阿膜西林500mg+甲硝唑400mg，bid；B组31例给予铋剂220mg+雷尼替丁150mg+阿莫西林500mg+甲硝唑400mg，bid；对照组（C组，23例）给予雷尼替丁150mg+阿莫西林500mg+甲硝唑400mg，bid；以上药物除抗菌药物只服用2周外，其余药物服至6周末疗程结束，第7周复查胃镜和 13 C呼气试验。

Methods 102patients with Hp associated peptic ulcer were randomly divided into three groups,groupA（n=98）received sanjiuweitai-based quadruple regimen（Yangweishul.2g,bid+ranitidine150mg,bid+amoxicillin500mg,bid+metronidazole400mg,bid）;group B（n=31）received colloidal bisˉmuth subcitrate110mg,bid+ranitidine150mg,bid+amoxicillin500mg,bid+metronidazole400mg,bid;groupC（n=23）received ranitidine150mg,bid+amoxicillin500mg,bid+metronidazole400mg,bid.Antibiotics were griven for two weeks,the other drugs were given for six weeks,the efficacies were determined by gastroendoscopy or 13 C—UBT.

将102例胃镜证实为消化性溃疡者随机分为3组，A组48例给予养胃舒1.2g+雷尼替丁150mg+阿膜西林500mg+甲硝唑400mg，bid；B组31例给予铋剂220mg+雷尼替丁150mg+阿莫西林500mg+甲硝唑400mg，bid；对照组（C组，23例）给予雷尼替丁150mg+阿莫西林500mg+甲硝唑400mg，bid；以上药物除抗菌药物只服用2周外，其余药物服至6周末疗程结束，第7周复查胃镜和 13 C呼气试验。

Methods 102patients with Hp associated peptic ulcer were randomly divided into threegroups,groupA（n=98）receivedsanjiuweitai-basedquadrupleregimen（Yangweishul.2g,bid+ranitidine150mg,bid+amoxicillin500mg,bid+metronidazole400mg,bid）;group B（n=31）received colloidal bisˉmuth subcitrate110mg,bid+ranitidine150mg,bid+amoxicillin500mg,bid+metronidazole400mg,bid;groupC（n=23）receivedranitidine150mg,bid+amoxicillin500mg,bid+metronidazole400mg,bid.Antibiotics were griven for two weeks,the other drugs were given for six weeks,the efficacies were determined by gastroendoscopy or 13 C―UBT.

将102例胃镜证实为消化性溃疡者随机分为3组，A组48例给予养胃舒1.2g+雷尼替丁150mg+阿膜西林500mg+甲硝唑400mg，bid；B组31例给予铋剂220mg+雷尼替丁150mg+阿莫西林500mg+甲硝唑400mg，bid；对照组（C组，23例）给予雷尼替丁150mg+阿莫西林500mg+甲硝唑400mg，bid；以上药物除抗菌药物只服用2周外，其余药服至6周末疗程结束，第7周复查胃镜和 13 C呼气试验。

It was showed that the imprinted polymer has good affinity and marked selectivity for the template molecule, and can be used to determine the trace amount of TBZ in biological and environemtal samples in an off-line mode. This methodology may be important for accurate investigation and determination of TBZ levels in the environmental and biological matrices.

研究结果表明，戊唑醇分子印迹聚合物对模板分子具有很强的亲和性和显著的选择性，可离线富集各种环境和生物样品中痕量的戊唑醇，在戊唑醇检测中具有实际的应用价值。

The results showed that the American shad fingerlings stopped opercular movement less than half an hour after anesthetia when the fish were exposed to concentration of MS-222 at 75mg/L, clove oil at 20mg/L and bezocaine at 40mg/L. The fish recovered to normal behaviors again after exposed in air for less than 10min when transferred into fresh water. The shad fingerlings had good anaesthesia for more than 12h at 20-30mg MS-222/L, 8-10mg/L clove oil and 20-30mg/L benzocaine. The anesthetic effects were enhanced at high water temperature and changed with fish sizes. Small fish were more easily in good anaesthesia than the bigger one in MS-222 while the opposite case was found in clove oil and in benzocaine.

麻醉试验结果表明：在较高麻醉浓度（MS-222为75mg/L以上，丁香油为20mg/L以上，苯唑卡因为40mg/L以上）下，鱼很快（30min内）停止鳃盖张合运动，且停止鳃盖运动的鱼在空气中暴露一定时间（10min内）后也能够复苏；在适宜的麻醉浓度（Ms-222为20~30mg/L，丁香油为8~10mg/L；苯唑卡因为20~30mg/L）下，鱼能够进入麻醉状态，且能保持很长时间(12h)；麻醉效果随着水温的升高而增强；在20mg/L MS-222麻醉剂下，小规格鱼较大规格鱼更容易进入麻醉状态，而在10mg/L丁香油和20mg/L苯唑卡因麻醉剂下，小规格鱼却难进入麻醉状态。

Methods: The health adult human primary hepatocyte microsome was randomly divided into 12 groups for control and itraconazole with different concentrations in the range of clinical drug blood concentration, each group have 10 samples. Control groups were added culture fluid, itraconazole groups were added itraconazole with different concentration respectively, after cultured 30 minutes, substrates (phenacetin for CYP1A2, testosterone for CYP3A4) were added and cultured for another 40 minutes.

采用健康成人肝细胞微粒体，分为对照组和不同浓度的伊曲康唑组，共12组，每组10个样本，伊曲康唑组分别加入血药浓度范围内不同对应浓度的伊曲康唑，对照组仅加入培养液，孵育30 min后，再加入CYP450同工酶1A2和3A4的相应底物再孵育40 min。

Gave patients in midazolam group intramuscular injection of midazolam at 0.1 mg/kg 10 min earlier before operation, while gave patients in phenobarbital sodium group 0.1 g phenobarbital sodium 30 min earlier. With Ramsay sedation evaluation assessed mean arterial pressure and heart rate during anesthesia, before and after operation, respectively.

选择ASA1～2级择期在腰硬联合阻滞下行下肢手术的患者180例，随机分为咪唑安定组和苯巴比妥钠组，咪唑安定组患者入室后(实施麻醉前10 min)肌内注射咪唑安定0.1 mg/kg，苯巴比妥钠组患者入室前30 min肌内注射苯巴比妥钠0.1 g。

Many of the aza quinazolines have showed potent activity, such as pyrido[2,3-d]pyrimidine, pyrido [3,2-d]pyrimidine, pyrido[4,3-d]pyrimidine, pyrido[3,4-d]pyrimidine, and pyrimido [5,4-d]pyrimidine. Moreover, the compounds that the benzene in quinazoline ring was substituted by five-member rings, such as pyrrolo[2,3-d]pyrimidine, pyrazolo[3,4-d]pyrimidine, can also inhibit the EGFR and show bright prospects.

然而喹唑啉环并非EGFR抑制剂所必须的，在随后的研究中，人们发现许多氮杂喹唑啉类也有很好的活性，如吡啶并[2，3-d]嘧啶类、吡啶并[3，2-d]嘧啶类、吡啶并[4，3-d]嘧啶类、吡啶并[3，4-d]嘧啶类、嘧啶并[5，4-d]嘧啶类，也就是在喹唑啉环的5，6，7，8-位都可以氮杂，且都有活性。

To make clinical go up Zun of use armour saltpetre is more reasonable, safe, the article injects with respect to armour saltpetre Zun the problem of conpatibility of medicines of fluid, make following discussing.

为了使临床上使用甲硝唑更加合理、平安，本文就甲硝唑注射液的配伍新问题，作如下探索。1和维生素的合理配伍使用1.1和维生素C注射液的配伍使用甲硝唑在5%葡萄糖溶液中加入处方量的维生素C放置24h，维生素C含量和pH值均无明显变化。

However, as the name（read－only memory）implies, CD disks cannot be written onorchanged in any way.

然而，正如其名字所指出的那样，CD盘不能写，也不能用任何方式改变其内容。

Galvanizes steel pallet is mainly export which suits standard packing of European Union, the North America. galvanizes steel pallet is suitable to heavy rack. Pallet surface can design plate type, corrugated and the gap form, satisfies the different requirements.

镀锌钢托盘多用于出口，替代木托盘，免薰蒸，符合欧盟、北美各国对出口货物包装材料的法令要求；喷涂钢托盘适用于重载上货架之用，托盘表面根据需要制作成平板状、波纹状及间隔形式，满足不同的使用要求。