唑

The azole drugs including fluconazole target lanosterol 14α-demethylase, the product of the ERG11 gene. Ergllp is one of the enzymes in the biosynthesis of ergosterol, the major sterol of fungal membranes and an analogue of cholesterol in mammalian systems.

唑类药物外流也是导致唑类耐药的主要原因，而与之药物外流泵相关的基因有ATP结合盒转运子基因(ATP Binding Cassette Transporter)——CDR1、CDR2和主要易化子基因——MDR1、FLU1，他们的过度表达可以导致唑类耐药的发生。

Earthworms might be a good bioindicator for the contamination of roxarsone to soil. No significant influence of roxarsone contamination upon the biomass and the reproductive ability of earthworms was found, which indicated that earthworms could tolerate heavy contamination of roxarsone. 2. Effects on the important enzymatic system of earthworms The activities of PROD, BROD and MROD in P450 family were inhibited.

对蚯蚓体内重要酶系统的影响洛克沙胂对P450酶系中的PROD（7-戊氧基异吩噁唑酮-O-脱乙基酶）、BROD（7-苄氧基异吩噁唑酮-O-脱乙基酶）和MROD（7-甲氧基异吩噁唑酮-O-脱乙基酶）的活性都有抑制作用，对MROD的抑制作用最明显；在抗氧化酶系统中，对过氧化氢酶在整个试验进程中都有激活作用，而对其他抗氧化酶有时起激活作用，有时起抑制作用，规律性不明显。

Ethyl 4-[(1-hydroxy-1-methyl)ethyl]-2-propyl-1H-imidazole-5-carboxylate,the key intermediate of Olmesartan ,was synthesized from butanoic acid and o-phenylenediamine via condensation under microwave-irradiation,oxidation,esterification and the Gringard reaction.

用正丁酸与邻苯二胺为原料，在微波照射下缩合成2-丙基苯并咪唑，再氧化开环制得2-丙基咪唑二羧酸，再经酯化、Gringard反应制得抗高血压药物奥美沙坦的关键中间体2-丙基-4-[(1-羟基-1-甲基)乙基]-1H-咪唑-5-羧酸乙酯，总收率32.2%。

Methods①The minimum inhibitory concentration and the minimum fungicidal concentration of citral against C.

方法①参照NCCLS M27A方案中的微量液基稀释法测定柠檬醛和氟康唑对原始白念珠菌的最低抑菌浓度和最低杀菌浓度；②采用多步诱导法，观察在含梯度浓度(1～50MIC)柠檬醛培养基上连续转种的白念珠菌MIC的变化情况，以氟康唑作为阳性对照，同时设空白对照和溶媒对照；③将敏感性下降的诱导株在无药培养基上连续转种10次后，检测其MIC值；④测定柠檬醛对氟康唑敏感性下降诱导株的MIC值。

Two bispyrazolylimine nickel complexes [bis-N-(phenyl-1,3,5-dimethylpyrazolylmethylene) phenylimine nickel dibromide] (Cat.1) and [bis-4-methoxy-N-(phenyl-1,3,5-dimethylpyrazolylmethylene) phenylimine nickel dibromide] (Cat.2) were synthesized.

合成了两种双吡唑亚胺镍配合物：双－N-（苯基－1-3，5-二甲基吡唑基亚甲基）苯基亚胺二溴化镍Cat.1）和双－4-甲氧基－N-（苯基－1-3，5-二甲基吡唑基亚甲基）苯基亚胺二溴化镍

The results showed that the maximum UV absorption wavelengths of those 1,3,4-oxadiazole derivatives in dichloromethane were in the range of 268~327 nm, and their maximum photoluminescent wavelengths in dichloromethane and solid film were located at 332~390 nm and 359~439 nm, respectively. The 1,3,4-oxadiao1e derivatives exhibit a first endothermal peak at 120~328℃ in the DSC heating process, and the symmetrical 1,3,4-oxadiazole derivatives display a higher melting temperature. The CV curves of those 1,3,4-oxadiazole derivatives indicate that the reductive potentials of the 1,3,4-oxadiazole derivatives are located at -1.03~0.98 V, and their LUMO(the lowest unoccoupied molecual orbit) energy levels are -3.71~-3.76eV.

结果表明，该类衍生物在二氯甲烷溶液中的最大紫外吸收波长在268~327nm范围，在二氯甲烷溶液和固体膜中的最大荧光发射波长分别在332~390nm和359~439nm范围；DSC分析结果表明，5个噁二唑衍生物的起始吸热峰位于120~328℃之间，其中对称结构的噁二唑衍生物显示了较高的熔融温度；由循环伏安图和相关计算结果表明，5个噁二唑衍生物的还原电位位于-1.03~-0.98V，其相应的最低非占有分子轨道能级在-3.71~-3.76 eV之间。

Ionic liquids of 1-carboxymethyl-3-ethylimidazolium chloride, 1-methoxyethyl- 3-ethylimidazolium chloride ([C2OC1-EIM]Cl) and 1-[2-(2-chloroethoxy)ethyl]-3-ethylimidazolium chloride ([Cl-C2OC2-EIM]Cl) were synthesized, and their chemical structures were confirmed by FT-IR and 1H NMR.

合成了三种含有羧基或醚基的离子液体， 1-羧甲基-3-乙基咪唑氯化物、1-甲氧乙基-3-乙基咪唑氯化物([C2OC1-EIM]Cl)和1-[2-(2-氯乙氧基)乙基]-3-乙基咪唑氯化物([Cl-C2OC2-EIM]Cl)，用FT-IR和1H NMR对它们的化学结构进行了表征。

The biological activity tests show that some target compounds have a good activity as plant growth regulator, and N-5-(3-carboxy-1H-1,2,4-triazolyl)-N'-o- chlorophenylfonnyl urea, N-5-(3-carboxy-1H-1,2,4-triazolyl)-N'-o- bromophenylformyl urea, N-5-(3-carboxy-1H-1,2,4-triazolyl)-N'-p- methyl-phenyl formyl urea have excellent activity of auxin.

生测试验证明部分酰基脲类化合物具有良好的植物生长调节活性，其中N-5（3-羧基-1，2，4-三唑基）-N'-o-氯苯甲酰基脲、N-5-（3-羧基-1，2，4-三唑基）-N'-o-溴苯甲酰基脲和N-5-3-羧基-1， 2，4-三唑基）-N'-p(或m-甲基苯甲酰基脲具有优良的生长素活性。

The chapter 1 introduces the background of imidazole, thiazole, tetrazole derivatives and their glycosides, and organic solid phase research.

论文第一章介绍了咪唑环、噻唑环、四氮唑环等杂环的合成，总结了糖苷的合成方法，对杂环的固相合成化学进行了简单介绍。

A novel zwitterion derived from the addition of thiazole carbene to ketene was discovered and captured by an activated alkyne. In this process, we developed a facile and efficient three-component tandem reaction involving thiazole or benzothiazole carbene, disubstituted ketene and activated alkyne.

我们发现了一种新的噻唑卡宾和烯酮形成的两性离子的存在，并用活泼炔成功捕捉，从而发展了一个新的噻唑卡宾或苯并噻唑卡宾、二取代烯酮和活泼炔的三组分串联反应。

However, as the name（read－only memory）implies, CD disks cannot be written onorchanged in any way.

然而，正如其名字所指出的那样，CD盘不能写，也不能用任何方式改变其内容。

Galvanizes steel pallet is mainly export which suits standard packing of European Union, the North America. galvanizes steel pallet is suitable to heavy rack. Pallet surface can design plate type, corrugated and the gap form, satisfies the different requirements.

镀锌钢托盘多用于出口，替代木托盘，免薰蒸，符合欧盟、北美各国对出口货物包装材料的法令要求；喷涂钢托盘适用于重载上货架之用，托盘表面根据需要制作成平板状、波纹状及间隔形式，满足不同的使用要求。