唑

Twelve new Schiff bases of 5-amino-1H-1,2,3,4-tetrazolyl were synthesized. These Schiff bases were further converted into α-(5- tetrazolyl)-aminoalkyl phosphonates.

合成了12个新的5—氨基—1H—1，2，3，4—四唑的Schiff碱，而后与亚磷酸二乙酯反应，合成出了12个新的含四唑基的α-氨基烃基膦酸酯，通过IR，^1H NMR，^31P NMR和元素分析证实了它们的结构。

By the nucleophilic substitution reaction of 6-O-tosyl-l,2:3,4-di-O- isopropylidene-a-Z-galactopyranose (3) with some substituted 1, 2,4- triazole-3-thiols (4a ~ 4c) or 1, 2, 3,4-tetrazole-5-thiols (5a~5f), nine 6-S-(substituted triazolyl or tetrazolyl)-l,2 : 3,4-di-O- isopropylidene-a-D-galactopyranoses (6a ~ 6i) were prepared in high yields. Their structures and configurations were analyzed and established by elemental analysis, IR, NMR, MS spectra.

报道了6－O－对甲苯磺酰基－1，2：3，4－二－O－异亚丙基－α-D吡喃型半乳糖（3）与取代的3－巯基三唑或5－巯基四唑4a-4c或5a-5f的亲核取代反应，合成了9个6－S－－1，2：3，4－二－O－异亚丙基－α- D吡喃型半乳糖（6a-6i），通过元素分析，IR，NMR和MS确证了上述化合物的结构，并经分子模型计算进行了其构象分析。

A compound of formula wherein R1 is hydrogen, halo or methoxy; R2 is hydrogen, halo, methyl, ethyl or methoxy; R3 is carboxy, tetrazolyl, or -CONHSO2R where R is methyl, ethyl, phenyl, 2,5-dimethylisoxazolyl or trifluoromethyl; T is -CH2- or -SO2-; and ring A is 3-chlorophenyl, 4-chlorophenyl, 3-trifluoromethylphenyl, 3,4-dichlorophenyl, 3,4-difluorophenyl, 3-fluoro-4-chlorophenyl, 3-chloro-4-fluorophenyl or 2,3-dichloropyrid-5-yl; or a pharmaceutically acceptable salt or prodrug thereof, as well as pharmaceutical compositions containing them are described and claimed.

本发明涉及一种式化合物，其中R 1 是氢原子、卤素或甲氧基；R 2 是氢原子、卤素、甲基、乙基或甲氧基；R 3 是羧基、四唑基或－CONHSO 2 R 4 ，其中R 4 是甲基、乙基、苯基、2，5－二甲基异∴唑基或三氟甲基；T是－CH 2 －或－SO 2 －；环A是3－氯苯基、4－氯苯基、3－三氟甲基苯基、3，4－二氯苯基、3，4－二氟苯基、3－氟－4－氯苯基、3－氯－4－氟苯基或2，3－二氯吡啶－5－基；或其药用允许的盐或前药，还包括所阐述和要求权利的含有它们的药用组合物。

Stuay on electronic structures and spectra properties of 3-phenly6-aryl-1,2,4 triazolo[3,4-b]thiadiazole with time-dependent density functional theory.

李会学，萧泰。3-苯基-6-芳基-1，2，4-三唑并[3，4-b]-1，3，4-噻二唑的电结构和光谱性质的含时密度泛函理论研究。

Methods On the basis of bioisosterism principles and by the method of substructure link, we modified the parent structure of 1, 3, 4-thiodiazole and synthesized a new kind of thiadiazole Schiff base. The structure of the new thiadiazole Schiff base was confirmed by infrared spectrum, nuclear magnetic resonance hydrogen spectrum (1HNMR) and elemental analysis.

利用生物等排原理和亚结构连接法，对噻二唑母体进行修饰，设计并合成了1个新的噻二唑席夫碱，目标化合物的结构经红外光谱、核磁共振氢谱和元素分析加以确证。

The rubbed surface was analyzed with XPS and EPMA, the results shown that the element S, N were as thiadiazole and imidazoline compounds in the rubbed surface film. The tribological properties of surface modified TiO〓 nanoparticles as water base lubrication additive was studied firstly.

用XPS、EPMA对摩擦后的磨斑表面进行了表面形貌，表面膜元素组成，及表面膜中的N〓、S〓电子结合能进行了考察，并与相应母体环化物的N〓、S〓进行了比较，发现摩擦后，磨斑表面膜中的S、N元素，主要是以噻二唑及咪唑啉的形式存在。

Methods 4-Hydroxy- benzonitrile was treated with sodium hydrogen sulfide and anhydrous magnesium chloride in dimethyl formamide to give thioamide, which was then directly cyclized with ethyl 2-chloroacetoacetate without separation to give ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate(2) in one-pot; then 2 was formylated with Duff reaction adopting hexamethylenetetramine in trifluoroacetic acid to give ethyl 2-(3-formyl-4-hydroxyphenyl)-4-methylthiazole-5-carboxylate(3); finally, the target compound was obtained by the treatment of 3 with hydroxylamine hydrochloride and sodium formate in formic acid.

采用&一勺烩&方法，以4-羟基苯甲腈为起始原料，首先与硫氢化钠和无水氯化镁在N，N-二甲基甲酰胺中反应，所得中间体不经分离，直接加入2-氯乙酰乙酸乙酯进行环合反应，得到2-(4-羟基)苯基-4-甲基-5-噻唑甲酸乙酯（2）；然后通过六亚甲基四胺/三氟乙酸进行Duff反应，得到2-(3-甲酰基-4-羟基)苯基-4-甲基-5-噻唑甲酸乙酯（3）；再经盐酸羟胺/甲酸/甲酸钠体系脱水得到目标化合物。

A series of urea,thiourea and thiodiazole derivatives bearing mercaptotetrazole were synthesized using NaN_3 as a nitrogen source.

以叠氮化钠为氮源，合成了一系列含四唑环的芳基脲及噻二唑类化合物，其结构经1H NMR，IR和元素分析表征。

Firstly the mid-pruduct imidazoline was produced by reaction of naphthenic acid and diethylene triamine, then the corrosion inhibitor amphoteric imidazoline, which is soluble in water, was produced by reaction of imidazoline and sodium monochloroacetate in aqueous solution.

以高纯环烷酸与二乙烯三胺反应合成了中间体咪唑啉，再以去离子水为溶剂，用氯乙酸钠对该中间体进行两性化，制得了水溶性两性咪唑啉缓蚀剂。

This thesis consists of two parts. In Chapter 1, we synthesized novel polyimides containing 1,2,4-triazole and triphenylamine groups. In Chapter 2, we synthesized polys in which main chain contains triazole group and side chain was carbazole group or triphenylamine group.

本实验共分两部分：第一章以合成含1，2，4-三氮唑和三苯胺结构的聚醯亚胺；第二章以合成三氮唑为主链，侧链分别含有咔唑与三苯胺之聚醚醯亚胺，并探讨其热性质、光学性质及应用。

And Pharaoh spoke to Joseph, saying, Your father and your brothers have come to you.

47：5 法老对约瑟说，你父亲和你弟兄们到你这里来了。

Additionally, the approximate flattening of surface strip using lines linking midpoints on perpendicular lines between geodesic curves and the unconditional extreme value method are discussed.

提出了用测地线方程、曲面上两点间短程线来计算膜结构曲面测地线的方法，同时，采用测地线间垂线的中点连线和用无约束极值法进行空间条状曲面近似展开的分析。