唑

After the use 四唑 salt is attackedcompared to the color experiment examination the cell survival and thegrowth situation.

使用四唑盐比色试验检测被攻击后细胞的存活和生长情况。

They had suppressed the cathodic process of carbon steel electrode. Their inhibition performance was also related with their molecule stereo conformation and electron configuration. Four of bis-(1, 1'-benzotriazoly)-α,β-diamide compounds linked via-CO 〓CO-chain were synthesized and certified by IR and 〓H-NMR. The minimum energy conformations of these compounds were obtained by MM2 forcefield program. The two benzotriazole moiety in BBT1 was more planar than in other compounds. This was beneficial in increasing the inhibition effects of BBT1. In 0.5M H〓SO〓 solution, BBT1 suppressed anodic corrosion reaction. In 3%NaCl solution, BBT1 suppressed both cathodic and anodic corrosion reactions. 1- [ (1'-imidazolly)-methyl] benzotriazole was synthesized by Mannich reaction.

合成了四个通过-CO〓CO-连接的双（1，1'-苯并三唑）-α，ω-二酰胺化合物，采用MM2分子力学程序优化了它们的分子结构，双（1，1'-苯并三唑）-α，ω-二酰胺化合物的缓蚀作用与其分子内两个苯并三唑单元的空间取向有关系，良好的平面性有利于苯并三唑二聚体的吸附和缓蚀作用，苯并三唑二聚体BBT1分子内两个苯并三唑单元近似平行，所以显示出较好的缓蚀效果。0.5M硫酸中BBT1主要抑制铜的阳极溶解的电化学反应；3％NaCl溶液中，BBT1对铜的阳极溶解和氧的阴极还原过程均有抑制作用，相比较而言对阴极过程的抑制作用更大一些。

Intravoneous injection of 0.5mg/kgBW jingsongling cause the 60 minutesrelaxation of goat gastric motor.The effects of jingsongling on the gastric motor ofgoat is major of effects of α2 -adrenoceptor agonist,as well as that of α1 -adrenoceptor agonist,the effects of α1 -adrenoceptor agonist concentrate at thecardic and pylorus;the function of α2 -adrenoceptor exit widely at cardic,pylorus,rumen,reticulum,omasum and abomasum,the function at different part is not the same.The lowestdose of jingsonglinginhibiting the amplitude and frequency of the gastricmyoelectric is 0.01mg/kgBW;the influence of jingsonglingto the gastricmotility of goat is dose-dependent,and the amplitude regain after the frequency ofgastric myoelectriv wave.When the goat revived,the gastric motor function is notreach the level of the normal;the major reason ofjingsongling cause the goat gastricrelaxation is the amplitude renew slowly.The intravoneous injection ofjingsonglingfirst,after 5 minutes,intravoneous injection the antagonist,the effect of prazosin and idazoxan mixed is best,which can fast reversal of theinhibition of jingsongling on the gastric motor of goat,the effects of idazoxan isgood,and the prazosin block the effection of jingsongling is better than that ofxylazine,especially at cardia and pylorus.When intravoneous injection of0.5mg/kgBW idazoxan and/or prazosin only,the amplitude of gastric myoelectric ingoat increases at a certain degree,but the frequency is not changed.

静脉注射0.5mk/kgBW的静松灵引起山羊胃蠕动弛缓长达60分钟；静脉注射0.5mg/kgBW的静松灵对山羊胃蠕动机能的影响是以α2肾上腺素受体作用为主的，兼有α1肾上腺素受体的作用，而且静松灵的α1肾上腺素受体的作用主要集中在幽门和贲门；α2肾上腺素受体的作用广泛存在于贲门、瘤胃、网胃、瓣胃、皱胃和幽门中，不同部位间有功能上的差异；静注0.01mg/kgBW的静松灵是对山羊的贲门、瘤胃、网胃、瓣胃、皱胃和幽门的肌电波频率和振幅均产生影响的最低剂量；静注一定剂量的静松灵对山羊胃蠕动的抑制作用与剂量呈相关性；而且山羊胃肌电波振幅的恢复比肌电波频率的恢复慢；苏醒时山羊的胃蠕动机能尚未恢复到正常状态；静松灵引起山羊胃弛缓的主要原因是由于胃肌电波的振幅恢复慢；静注0.5mg/kgBW的静松灵，5分钟后静注0.5mg/kgBW的拮抗剂时，咪唑克生+哌唑嗪的作用最好，能迅速地逆转静松灵对山羊胃蠕动的抑制作用，咪唑克生也有很强的拮抗作用，而哌唑嗪对静松灵的拮抗效果好于对隆朋的拮抗；单独静注0.5mg/kgBW的咪唑克生和/或哌唑嗪时，山羊的瘤胃、网胃、瓣胃、皱胃、贲门和幽门的肌电波振幅有一定程度的增强，而肌电波频率未见变化。

In order to find active pesticide leading compounds, thinking about that triazolothiadiazoles had various biological activities, this paper designed and synthesized 11 novel title compounds from 3-substituted-4-amino-5-mercapto-1,2,4-triazoles with heterocyclic carboxylic acid via cyclization in the presence of phosphoryl chloride by the princple of combination of active strucural moieties. The structures of the title compounds were characterized by melting point, IR, 1HNMR and elemental analysis.

为了寻找高活性农药先导化合物，考虑到三唑并噻二唑衍生物具有广泛的生物活性，本文利用活性亚结构拼接原理，将活性基团分别引入1，2，4-均三唑并[3，4-b]-1，3，4-噻二唑杂环的3位和6位，合成了未见文献报道的3，6-二取代均三唑并[3，4-b]-1，3，4-噻二唑类化合物11个，并用IR、1HNMR及元素分析测试技术对其进行了结构表征。

Synthesis of target compounds namely: to vanillic acid as the starting material with methanol under reflux conditions for 4 - hydroxy -3 - p-methyl, then ether, and nitration, reduction, cyclization reaction 6 - methoxy -7 - benzyloxy-quinazoline -4 - one, and then by the chloride in place of aniline, benzyloxy-off, such as etherification reaction of the target compounds; target compounds with the second and third occurrence of substitution reactions of amines by the TM1, that is, 4 - amino-benzene -6 - methoxy -7 - [2 - hydroxy -3 -(N, N-diethyl amino) oxy c] quinazoline; with ether occurred Ornidazole reaction of TM2, namely, 4 - amino-benzene -6 - methoxy -7 - [2 - hydroxy -3 -(2 - methyl -5 - nitroimidazole) C oxy] quinazoline.

本论文以嘌呤类似物喹唑啉为母核，分别在其4位和7位引入结构多样的取代苯氨基和柔性侧链，设计了一系列4-取代苯胺基-6-甲氧基-7-(2-羟基取代丙氧基)喹唑啉类化合物。目标化合物的合成即：以香草酸为起始原料，与甲醇回流条件下得到4-羟基-3-甲氧基苯甲酸甲酯，然后经过醚化、硝化、还原、环合反应得到6-甲氧基-7-苄氧基喹唑啉-4-酮，然后再经氯化、取代苯胺、脱苄氧基、醚化等反应得到目标化合物；目标化合物与二乙胺发生胺取代反应得到了TM1，即4-苯氨基-6-甲氧基-7-[2-羟基-3-丙氧基]喹唑啉；通过与奥硝唑发生醚化反应得到TM2，即4-苯氨基-6-甲氧基-7-[2-羟基-3-(2-甲基-5-硝基咪唑)丙氧基]喹唑啉。

Replacement of one benzimidazole fragment with benzothiazole or benzoxazole and optimization of the structure to create the new frame of the compounds were also carried out with the exception to find more potent compounds. The purpose of design and synthesis of these compounds is to investigate the QSAR of this class of compounds with the inhibition of HCV NS3/NS4A protease and eventually to develop more potent inhibitors.

本文首次采用了丙二酰胺与邻芳二胺在微波辐射下制备对称性双芳并唑甲烷化合物、用芳并唑-2-乙酸乙酯与邻芳二胺在微波辐射下制备非对称性双芳并唑甲烷化合物、用4-取代噻唑-2-乙酸乙酯与邻芳二胺在微波辐射下制备非对称性(4-取代-噻唑-2-基)(1H-芳并咪唑-2-基)甲烷化合物等合成路线，共合成了48个目标化合物，其中41个为新化合物，用~1HNMR，ESI-MS，FT-IR，元素分析对这些化合物进行了全面表征，确定了这些化合物的结构，并对部分化合物进行了~(13)CNMR分析。

In this paper, eleven benzothiazole derivatives such as N, N, N′, N′-tetra (2-benzothiazolyl) methyl-1, 2-ethanediamine,(2-benzothiazolyl) methyloxy benzene, 2,4-dichloro( 2-benzothiazolyl) methyloxy benzene, O-di(2-benzothiazolyl) methyloxybenzene, P-di(2-benzothiazolyl) methyloxy benzene, 3-(2-benzothiazolyl) pyridine were synthesized by means of conventional method or MWI technology and a single crystal of di (2-benzothiazolyl ) methyl ether was obtained.

本文分别用常规合成法和微波辐射法合成了N，N，N′， N′-四(2-苯并噻唑基)甲基-1，2-乙二胺、(2-苯并噻唑基)甲氧基苯、2，4-二氯-(2-苯并噻唑基)甲氧基苯、邻-二(2-苯并噻唑基)甲氧基苯、对-二(2-苯并噻唑基)甲氧基苯、3-(2-苯并噻唑基)吡啶等11 个苯并噻唑类化合物并得到二(2-苯并噻唑基)甲基醚单晶。

Their structures were characterized by IR, 1H NMR, of which 4-chloro- 2-methyl-7-(2-bromoethoxy) isoflavone, 2, 4\'-dimethyl-7-(2-bromo-ethoxy)isoflavone and 2-methyl-7-(2-bromoethoxy) isoflavone are rarely reported so far.4\'-chloro-2-methyl-7-(3-bromopropoxy)isoflavone, 2, 4\'-dimethyl-7-(3-bromo- propoxy) isoflavone, 2-methyl-7-(3-bromopropoxy) isoflavone, 4\'-methoxy-2-methyl-7-(3-bromopropoxy) isoflavone and 4\'-hydroxy-2-methyl-7-(3-bromopropoxy) isoflavone were gained by reacting 7-hydroxy-2-methyl isoflavone derivatives with 1, 3-dibromo- propane, respectively.

第三章(来源：73ABC论文网www.abclunwen.com)在丙酮溶液中以K_2CO_3为碱，使溴乙氧基异黄酮和溴丙氧基异黄酮与咪唑偶合，以较高的产率合成出10种目标化合物：2-甲基-4′-氯-7-2-(1-咪唑基乙氧基异黄酮、2，4′-二甲基-7-2-(1-咪唑基乙氧基异黄酮、2-甲基-7-2-(1-咪唑基乙氧基异黄酮、2-甲基-4′-甲氧基-7-2-(1-咪唑基乙氧基异黄酮、2-甲基-4′-羟基-7-2-(1-咪唑基乙氧基异黄酮、2-甲基-4′-氯-7-3-(1-咪唑基丙氧基异黄酮、2，4′-二甲基-7-3-(1-咪唑基丙氧基异黄酮、2-甲基-7-3-(1-咪唑基丙氧基异黄酮、2-甲基-4′-甲氧基-7-3-(1-咪唑基丙氧基异黄酮、2-甲基-4′-羟基-7-3-(1-咪唑基丙氧基异黄酮，经IR、~1H NMR、~(13)C NMR、元素分析等对其结构进行了表征，10种目标产物均未见文(来源：ABC论文cccccc网www.abclunwen.com)献报道。

In the first part, five new 4-acyl pyrazolone 4-ethyl-thiosemicarbazones compounds: 1-Phenyl-3-methyl-4-(4-bromo)benzal-pyrazol-5-one N(4)-ethyl-thiosemicarbazone (PM4Br BP-ETSC), 1-Phenyl-3-methyl-4-(4-methyl)benzal-pyrazol-5-one N(4)-ethyl-thiosemicarbaz -one (PM4MBP-ETSC), 1-Phenyl-3-methyl-4-benzal-pyrazol-5-one N(4)-ethyl-thiosemicarba -zone, 1,3-diphenyl-4-benzal-pyrazol-5-one N(4)-ethyl-thiosemicarbazone and 1-Phenyl-3-methyl-4-phenylacetyl-pyrazol-5-one N(4)-ethyl-thiosemi -carbazone have been synthesized and characterized by elemental analyses, IR, 1H NMR spectra and single-crystal XRD.

第一部分合成了五个4-酰基吡唑啉酮缩4-乙基-氨基硫脲化合物：1-苯基-3-甲基-4-（4-溴）苯甲酰基-5-吡唑啉酮缩4-乙基-氨基硫脲(PM4BrBP-ETSC)，1-苯基-3-甲基-4-(4-甲基)苯甲酰基-5-吡唑啉酮缩4-乙基-氨基硫脲(PM4MBP-ETSC)，1-苯基-3-甲基-4-苯甲酰基-5-吡唑啉酮缩4-乙基-氨基硫脲，1，3-二苯基-4-苯甲酰基-5-吡唑啉酮缩4-乙基-氨基硫脲和1-苯基-3-甲基-4-苯乙酰基-5-吡唑啉酮缩4-乙基-氨基硫脲，其中前四个具有光致变色性质。

Sensitivity results to ten antifungals showed that the frequent fungi were sensitive to amphotericin b, nystatin, econazaole, miconazole, clotrimazole, ketoconazole, flucytosine, itraconazole, fluconazole and griseofulvin.

常见真菌对常见抗真菌药物的敏感性由高到底依次为两性霉素b、制霉菌素、益康唑、克霉唑、酮康唑、咪康唑、5-氟胞嘧啶、伊曲康唑、氟康唑、灰黄霉素。

However, as the name（read－only memory）implies, CD disks cannot be written onorchanged in any way.

然而，正如其名字所指出的那样，CD盘不能写，也不能用任何方式改变其内容。

Galvanizes steel pallet is mainly export which suits standard packing of European Union, the North America. galvanizes steel pallet is suitable to heavy rack. Pallet surface can design plate type, corrugated and the gap form, satisfies the different requirements.

镀锌钢托盘多用于出口，替代木托盘，免薰蒸，符合欧盟、北美各国对出口货物包装材料的法令要求；喷涂钢托盘适用于重载上货架之用，托盘表面根据需要制作成平板状、波纹状及间隔形式，满足不同的使用要求。